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The Role of High Performance Liquid Chromatography in Radiochemical/Radiopharmaceutical Synthesis and Quality Assurance

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New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control

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Abstract

High Performance Liquid Chromatography(HPLC) is a versatile tool in radiopharmaceutical chemistry. Instrumentation, methods and applications have been reviewed as recently as 19861. HPLC has been used for numerous areas associated with the production of radiopharmaceuticals including:

  • analysis of radiochemical and chemical starting materials;

  • determination of both labelled and unlabelled reaction products;

  • optimization of reaction conditions;

  • purification, including separation from chemical and radiochemical impurities;

  • determination of specific activity;

  • determination of radiochemical and chemical purity;

  • determination of the stability of the radiolabelled product during storage, including determination of radiolysis products;

  • validation of other methods of analysis, such as TLC;

  • determination of metabolites.

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  1. Cyclotron Facility, Mount Sinai Medical Center, Miami Beach, FL, USA

    Thomas E. Boothe

  2. Positron Diagnostic and Research Center, University of Texas Health Science Center, Houston, TX, USA

    Ali M. Emran

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  1. Thomas E. Boothe
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  1. The University of Texas Health Science Center, Houston, Texas, USA

    Ali M. Emran

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Boothe, T.E., Emran, A.M. (1991). The Role of High Performance Liquid Chromatography in Radiochemical/Radiopharmaceutical Synthesis and Quality Assurance. In: Emran, A.M. (eds) New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0626-7_38

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  • DOI: https://doi.org/10.1007/978-1-4899-0626-7_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0628-1

  • Online ISBN: 978-1-4899-0626-7

  • eBook Packages: Springer Book Archive

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