Abstract
The concentration of taurine in the striatum is high (23, 29). High-affinity taurine uptake has been demonstrated in striatal synaptosomes (5, 24), and selective uptake into a subpopulation of striatal neurons (4). Both the content and K+ -stimulated release of taurine are reduced after an intrastriatal injection of kainate, indicating a neuronal localization of the amino acid (25, 31). Although electrophysiological data on taurine in the striatum are scant, the above evidence suggests that taurine is involved in striatal functions. The striatum is particularly rich in dopaminergic neurons, rendering it possible that taurine could modulate dopaminergic transmission. Indeed, intraventricularly injected taurine increases the synthesis of dopamine in the rat brain and inhibits the firing of dopamine neurons (7). Intraventricular taurine also stimulates prolactin secretion, possibly via interaction with dopamine or serotonin transmitter systems (34), and unilateral intranigral injection of taurine induces a dose-dependent contralateral circling behavior which is partially blocked by haloperidol (12). I have now further elucidated the modulatory role of taurine in the function of striatal dopaminergic systems by studying mutual interactions of taurine and dopamine in release and uptake processes in the rat striatum. The effects of taurine on the binding of tritiated spiperone, a ligand for dopamine receptors, to striatal synaptic membranes was also investigated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andersen, L., Sundman, L.-O., Linden, I.-B., Kontro, P., and Oja, S.S., 1984, Synthesis and anticonvulsant properties of some 2-amino-ethanesulphonic acid (taurine) derivatives, J. Pharm. Sci., 73: 106–108.
Banay-Schwartz, M., Wajda, I.J., Manigault, I., DeGuzman, T., and Lajtha, A., 1982, Lithium: effect on [3H] spiperone binding, ionic content, and amino acid levels in the brain of rats, Neurochem. Res., 7: 179–189.
Chesselet, M.-F., 1984, Presynaptic regulation of neurotransmitter release in the brain: facts and hypotheses. Neuroscience, 12: 347–375.
Clarke, D.J., Smith, A.D., and Bolam, J.P., 1983, Uptake of [3H] taurine into medium-size neurons and into identified striatonigral neurons in the rat neostriatum, Brain Res., 289: 342–348.
Collins, G.G.S., 1974, The rates of synthesis, uptake and disappearance of [14C] taurine in eight areas of the rat central nervous system, Brain Res., 76: 447–459.
Dismukes, R.K., De Boer, A.A., and Mulder, A.H., 1977, The mechanism of alpha-receptor mediated modulation of [3H]noradrenaline release from slices of rat neocortex, Naunyn-Schmiedebergs Arch. Pharmac, 299: 115–122.
Garcia de Yebenes Prous, J., Carlsson, A., and Mena Gomez, M.A., 1978, The effect of taurine on motor behaviour, body temperature and monoamine metabolism in rat brain, Naunyn-Schmiedebergs Arch. Pharmac, 304: 95–99.
Girault, J.A., Barbeito, L., Spampinato, U., Gozlan, H., Glowinski, J., and Besson, M.-J., 1986, In vivo release of endogenous amino acids from the rat striatum: further evidence for a role of glutamate and aspartate in corticostriatal neurotransmission, J. Neurochem., 47: 98–106.
Hancock, A.A., and Marsh, C.L., 1984, Distinctions between ligand-binding sites for [3H]dopamine and D2 dopaminergic receptors characterized with [3H]spiroperidol, Mol. Pharmac, 26: 439–451.
Howlett, D.R., and Nahorski, S.R., 1980, Quantitative assessment of heterogeneous [3H]spiperone binding to rat neostriatum and frontal cortex, Life Sci., 26: 511–517.
Huff, R.A.M., and Molinoff, P.B., 1982, Quantitative determination of dopamine receptor subtypes not linked to activation of adenylate cyclase in rat striatum, Proc Natl Acad. Sci. USA, 79: 7562–7565.
Kaakkola, S., and Kääriäinen, I., 1980, Contralateral circling behavior induced by intranigral injection of taurine in rats. Acta Pharmac. Toxic (Kbh), 46: 293–298.
Kerwin, R., and Pycock, C., 1979, Effects of co-amino acids on tritiated dopamine release from rat striatum: evidence for a possible glycinergic mechanism, Biochem. Pharmac, 28: 2193–2197.
Kontro, P., 1984, Comparison of taurine, hypotaurine and ß-alanine uptake in brain synaptosomal preparations from developing and adult mouse, Int. J. Dev. Neurose1., 2: 465–470.
Kontro, P., and Oja, S.S., 1978, Taurine uptake by rat brain synaptoomes, J. Neurochem., 30: 1297–1304.
Kontro, P., and Oja, S.S., 1984, Binding and uptake of taurine and GABA in developing and adult mouse brain, Acta Univ. Tamper. [B], 21: 60–67.
Kontro, P., and Oja, S.S., 1985, Properties of sodium-independent taurine binding to brain synaptic membranes, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro and M.K. Paasonen, eds. Alan R. Liss, New York, pp. 249–260.
Kontro, P., and Oja, S.S., 1986, Taurine interferes with spiperone binding in the striatum, Neuroscience, 19: 1007–1010.
Kontro, P., and Oja, S.S., 1987, Taurine efflux from brain slices: potassium-evoked release is greater from immature than mature brain tissue, in this volume.
Kontro, P., and Oja, S.S., 1987, Taurine and GABA release from mouse cerebral cortex slices: effects of structural analogues and drugs, Neurochem. Res., 12: 475–482.
Korpi, E.R., and Oja, S.S., 1979, Efflux of phenylalanine from rat cerebral cortex slices as influenced by extra-and intracellular amino acids, J. Neurochem., 32: 789–796.
Korpi, E.R., and Oja, S.S., 1984, Comparison of two superfusion systems for study of neurotransmitter release from rat cerebral cortex slices, J. Neurochem., 43: 236–242.
Lombardini, J.B., 1976, Regional and subcellular studies on taurine in the rat central nervous system, in: “Taurine”, R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp. 311–326.
Lombardini, J.B., 1978, High-affinity transport of taurine in the mammalian central nervous system, in: “Taurine and Neurological Disorders”, A. Barbeau and R.J. Huxtable, eds., Raven Press, New York, pp. 119–135.
Nicklas, W.J., Duvoisin, R.C., and Berl, S., 1979, Amino acids in the rat neostriatum: alteration by kainic acid lesion, Brain Res., 167: 107–117.
Nomura, Y., Oki, K., and Sewaga, T., 1982, Ontogenic development of the striatal [3H]spiperone binding: regulation by sodium and guanine nucleotide in rats, J. Neurochem., 38: 902–908.
Oja, S.S., and Kontro, P., 1980, Hypotaurine uptake by brain slices from adult and 8-day-old mice, J. Neurochem., 35: 1303–1308.
Oja, S.S., Kontro, P., and Lähdesmäki, P., 1977, Amino acids as inhibitory neurotransmitters, Prog. Pharmac, 1 (3): 1–119.
Perry, T.L., Sanders, H.D., Hansen, S., Lesk, D., Kloster, M., and Gravlin, L., 1972, Free amino acids and related compounds in five regions of biopsied cat brain, J. Neurochem., 19: 2651–2656.
Pin, J.-P., Weiss, S., Sebben, M., Kemp, D.E., and Bockaert, J., 1986, Release of endogenous amino acids from striatal neurons in primary culture, J. Neurochem., 47: 594–603.
Placheta, P., Singer, E., Schönbeck, G., Heckl, K., and Karobath, M., 1979, Reduction of endogenous level, uptake and release of taurine after intrastriatal kainic acid injection, Neuropharmacology, 18: 399–402.
Pycock, C.J., and Smith, L.F.P., 1983, Interactions of dopamine and the release of [3H]-taurine and [3H]-glycine from the isolated retina of the rat, Br. J. Pharmac, 78: 395–404.
Raiteri, M., Marchi, M., and Maura, G., 1984, Release of catecholamines, serotonin, and acetylcholine from isolated brain tissue, In: “Handbook of Neurochemistry, 2nd edn, vol. 6”, A. Lajtha, ed., Plenum Press, New York, pp. 431–462.
Scheibel, J., Elsasser, T., and Ondo, J.G., 1980, Stimulation of prolactin secretion by taurine, a neurally depressant amino acid, Neuroendocrinology, 30: 350–354.
Seeman, P., 1980, Brain dopamine receptors, Pharmac. Rev., 32: 229–313.
Sharp, T., Zetterström, T., and Ungerstedt, U., 1986, An in vivo study of dopamine release and metabolism in rat brain regions using intra-cerebral dialysis, J. Neurochem., 47: 113–122.
Smith, L.F.P., and Pycock, C.J., 1982, Potassium-stimulated release of radiolabelled taurine and glycine from the isolated rat retina, J. Neurochem., 39: 653–658.
Toivonen, M.-L., Linden, I.-B., and Vapaatalo, H., 1984, Effect of taltrimide on dopamine mediated behaviour. Abstracts of the Symposium Taurine: Biological Actions and Clinical Perspectives, p. 49, Hanasaari, Espoo.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kontro, P. (1987). Interactions of Taurine and Dopamine in the Striatum. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_37
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0405-8_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0407-2
Online ISBN: 978-1-4899-0405-8
eBook Packages: Springer Book Archive