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Taurine Inhibits Wet-Dog Shakes and Hippocampal Seizures Induced by Opioid Peptides in Rats

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The Biology of Taurine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 217))

Abstract

Wet dog shakes (WDS) are paroxysmal shudders of head, neck and trunk. This behavior has been observed when dipping animals into cold water (41), application of xylene to the für (39) and tactile stimulation around ears (1). Pharmacological studies revealed that WDS can be produced by administration of thyrotropin-releasing hormone (9,24,29,41,42), 5-Hydroxytryptamine (3,12), or kainic acid (5,25). WDS are also known as a classical sign of morphine abstinence in rats (40,43). In 1976, Bloom et al. first reported that this shaking behavior was elicited by acute administration of β-endorphln into the lateral ventricle in rats. Similar observations were made in rats with enkephalin (15). In addition, it was found that epileptic discharges were provoked by the intraventricular (icv) injection of opioid peptides and WDS always accompanied the onset of seizure discharges (15,16,37). These findings suggest that there may be an association between electrical seizure activities and WDS.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Kagoshima University, Kagoshima 890, Japan

    Kanji Izumi, Takeshi Koja & Takeo Fukuda

  2. Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305, Japan

    Motoaki Yoshida & Takao Nakanishi

  3. Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan

    Eisuke Munekata

Authors
  1. Kanji Izumi
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  2. Motoaki Yoshida
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  3. Takeshi Koja
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  4. Eisuke Munekata
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  5. Takao Nakanishi
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  6. Takeo Fukuda
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Editors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA

    Ryan J. Huxtable

  2. Cattedra di Saggi e Dosaggi Farmacologici, Facolta di Farmacia, Universita di Sassari, Via Muroni, 23, Sassari, Italy

    Flavia Franconi

  3. Department of Preclinical and Clinical Pharmacology “Mario Aiazzi Manzini”, Universita di Firenze, Firenze, Italy

    Alberto Giotti

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© 1987 Springer Science+Business Media New York

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Izumi, K., Yoshida, M., Koja, T., Munekata, E., Nakanishi, T., Fukuda, T. (1987). Taurine Inhibits Wet-Dog Shakes and Hippocampal Seizures Induced by Opioid Peptides in Rats. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_24

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  • DOI: https://doi.org/10.1007/978-1-4899-0405-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0407-2

  • Online ISBN: 978-1-4899-0405-8

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