Skip to main content
SpringerLink
Log in

Cardiovascular Pharmacology and Experimental Therapeutics of Taurine and Related Compounds

  • Chapter
Book cover The Biology of Taurine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 217))

Abstract

Let me thank the members of the Scientific Committee, Drs. Flavia Franconi, Ryan J. Huxtable, Simo S. Oja and Kenji Yamaguchi for having selected me to lecture in this opening ceremony. The main subject of this lecture is taurine, 2-aminoethane sulfonic acid, an amino acid with zwitterion characteristics, probably a very old molecule widely represented in the animal kingdom, important for osmoregulation in primitive sea animals and also for feeding behavior, in so far as it is a agonist for antennular receptors in the lobster (27), as we shall have the opportunity to discuss in the Symposium (33).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Azuma, J., Sawamura, A., Awata, N., Hasegawa, H., Ogura, K., Harada, H., Ohta, H., Yamaguchi, K., and Kishimoto, S., 1983, Double-blind randomized crossover trial of taurine in congestive heart failure, Current Ther. Res. 34:543–557.

    Google Scholar 

  2. Azuma, J., Takihara, K., Awata, N., Ohta, H., Sawamura, A., Harada, H., and Kishimoto, S., 1984, Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits, Res. Comm. Chem. Path. Pharm. 45:261–270.

    CAS  Google Scholar 

  3. Bavazzano, A., Sidell, N., Michelacci, S., Sicuteri, F., 1969, Local ischemia as a kininogen depressant: effect of cortisone, taurine and kallikrein inhibitor, Pharmacol. Res. Comm. 1:137–138.

    Article  Google Scholar 

  4. Becattini, V., 1976, Prospettive di un nuovo farmaco nella terapia delle vasculopatie: la taurina, La Settimana Medica 55:1355–1365.

    Google Scholar 

  5. Bennardini, F., Franconi, F., Giotti, A., Matucci, R., and Stendardi, I., 1985, Binding of H-nitrendipine during hypoxia and subsequent reoxygenation, Br. J. Pharmacol. 86:623P.

    Google Scholar 

  6. Brodle, B.B., Axelrod, J., Soberman, R., and Levy, B.B., 1949, The estimation of antipyrine in biological materials, J. Biol. Chem. 179:25–29.

    Google Scholar 

  7. Buffoni Nardini, F., and Giotti, A., 1955, Titolazione dei glucosidi digitalici nella cavia, II Farmaco, Ed. Pr. 11:615–642.

    Google Scholar 

  8. Colucci, W.S., Wright, R.F., and Braunwald, E., 1986, New positive inotropic agents in the treatment of congestive heart failure, First of two parts, N. Engl. J. Med. 314:290–299.

    Article  PubMed  CAS  Google Scholar 

  9. Colucci, W.S., Wright, R.F., and Braunwald, E., 1986, New positive inotropic agents in the treatment of congestive heart failure, Second of two parts, N. Engl. J. Med. 314:349–358.

    Article  PubMed  CAS  Google Scholar 

  10. Corr, P.B., and Grafforol, A.W., 1981, Enhanced alpha-adrenergic responsiveness in ischemic myocardium: role of alpha adrenergic blockade, Am. Heart J. 102:605–611.

    Article  PubMed  CAS  Google Scholar 

  11. Crass, M.F., III and Lombardini, J.B., 1977, Loss of cardiac muscle taurine after acute left ventricular ischemia, Life Sci 21:951–958.

    Article  PubMed  CAS  Google Scholar 

  12. De Rango, F., and Del Corso, P., 1968, Modificazioni elettrocardiografiche indotte dalla taurina nelle cardiopatie coronariche, Recentl Progressi in Medicina 14:19–51.

    Google Scholar 

  13. Dietrich, J., and Diacono, J., 1971, Comparison between ouabain and taurine effects on isolated rat and guinea-pig hearts in low calcium medium, Lif Sci 10:499–507.

    Article  CAS  Google Scholar 

  14. Dolara, P., Agresti, A., Giotti, A., and Pasquini, G., 1973, Effect of taurine on calcium kinetics of guinea-pig heart. Eur. J. Pharmacol. 24:352–358.

    Article  PubMed  CAS  Google Scholar 

  15. Fanciullacci, M., Sicuteri, F., Giotti, A., and Brunetti, S., 1970, La taurina come fibrinolotico nell’uomo: prime osservazioni terapeutiche, La Clinica Terapeutica 53:3–8.

    PubMed  CAS  Google Scholar 

  16. Fellman, J.H., Roth, E.S., Avedovech, N.A., and McCarthy, K.D., 1980, The metabolism of taurine to isethionate, Arch. Biochem. Biophys. 204:560–567.

    Article  PubMed  CAS  Google Scholar 

  17. Franconi, F., Bennardini, F., Matucci, R., Stendardi, I., Failli, P., Manzini, S., and Giotti, A., 1986, Functional and binding evidence of taurine inhibition of alpha adrenoceptor effects on guinea-pig ventricle, J. Mol. Cell Cardiol 18:461–468.

    Article  PubMed  CAS  Google Scholar 

  18. Franconi, F., Giotti, A., Manzini, S., Martini, F., Stendardi, I., and Zilletti, L., 1982, The effect of taurine on high potassium and noradrenaline-induced contraction in rabbit ear artery, Br. J. Pharmao. 75:605–612.

    Article  CAS  Google Scholar 

  19. Franconi, F., Manzini, S., Stendardi, I., Bennardini, F., Antonini, G., Failli, P., Matucci, R., and Giotti, A., 1982, Differential inhibitory effect of taurine on contractile responses to potassium and noradrenaline in rabbit ear artery, J. Pharm. Pharmacol. 35:46–48.

    Article  Google Scholar 

  20. Franconi, F., Martini, F., Manghi, N., Galli, A., Bennardini, F., and Giotti, A., 1981, Uptake of H-Taurine into myocardial membranes, Biochem. Pharmacol. 30:77–80.

    Article  PubMed  CAS  Google Scholar 

  21. Franconi, F., Martini, F., Stendardi, I., Matucci, R., Zilletti, L., and Giotti, A., 1982, Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips, Biochem. Pharmacol. 31:3181–3185.

    Article  PubMed  CAS  Google Scholar 

  22. Franconi, F., Stendardi, I., Failli, P., Fazzini, A., and Giotti, A., Inotropic activity of orthanilic and L-cysteic acid on isolated guinea-pig ventricular strips, In this volume.

    Google Scholar 

  23. Franconi, F., Stendardi, T., Failli, P., Matucci, R., Baccaro, C, Montorsi, L., Bandinelli, R., and Giotti, A., 1985, The prospective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart, Biochem. Pharmacol. 34:2611–2615.

    Article  PubMed  CAS  Google Scholar 

  24. Franconi, F., Stendardi, I., Martini, F., Zilletti, L., and Giotti, A., 1982, Interaction between organic calcium-channel blockers and taurine in vitro and in vivo, J. Pharm. Pharmacol. 34:329–330.

    Article  PubMed  CAS  Google Scholar 

  25. Franconi, F., Stendardi, T., Matucci, R., Failli, P., Bennardini, F., Antonini, G., and Giotti, A., 1984, Inotropic effect of taurine in guinea pig ventricular strips, Eur. J. Pharmacol. 102:511–514.

    Article  PubMed  CAS  Google Scholar 

  26. Franconi, F., Failli, P., Stendardi, I., Matucci, R., Bennardini, F., Baccaro, C., and Giotti, A., 1986, Positive inotropic effect of some taurine-related compounds on guinea-pig ventricular strips perfused with low calcium medium, Eur. J. Pharmacol. 124:129–133.

    Article  PubMed  CAS  Google Scholar 

  27. Fuzussery, Z.M., Carr, W.E.S., and Ache, B.W., 1978, Antennular chemosensitivity in the spiny lobster, Panulinus Argus: studies of taurine sensitive receptors, Biol. Bull. 154:226–240.

    Article  Google Scholar 

  28. Gagliarducci, U., 1971, Possibilita’ terapeutiche di un aminoacido solforato nelle eritrocitosi ipo-ossiche, Clin. Ter. 58:145–150.

    PubMed  CAS  Google Scholar 

  29. Gagliarducci, U., 1974, Sul trattamento delle cardiopatie ischemiche acute con taurina, Osservazioni cliniche su trenta casi, Clin. Ter. 68:261–270.

    PubMed  CAS  Google Scholar 

  30. Giotti, A., 1959, Rapporti fra tempo diastolico, concentrazione degli elettroliti ed effetti della chinidina nel miocardio atriale di mammifero, Lo Sperimentale 109:129–188.

    CAS  Google Scholar 

  31. Giotti, A., Ledda, F., Franconi, F., Mantelli, L., and Mugelli, A., 1984, Cardiac alpha adrenergic receptors: do they have a role? In: Frontiers in Cardiology for the eighties, ed. by L. Donato and A. L’Abbate, pp. 127–129. Academic Press Inc. Ltd. (London).

    Google Scholar 

  32. Giotti, A., Personal observations, Unpublished.

    Google Scholar 

  33. Gleeson, R.A., A taurine receptor model: taurine-sensitive olfactory cells in the lobster, This volume.

    Google Scholar 

  34. Goodford, P.J. and Lullmann, H., 1962, The uptake of ethanesulphonate-S ions by muscular tissue, J. Physiol. 161:54–61.

    PubMed  CAS  Google Scholar 

  35. Guidotti, A., Buffoni, F., and Giotti, A., 1967, Azione della taurina e di alcuni suoi derivati sulla riduzione del consumo di ossigeno prodotta dal cianuro nel ratto, Boll. Soc. Ital. Biol. 43:1390–1392.

    CAS  Google Scholar 

  36. Guidotti, A., Buffoni, F., and Giotti, A., 1967, Ricerche sull’ interazione taurina-cianuro nel ratto, Boll. Soc. Ital. Bio. Sper. 43:1392–1395.

    CAS  Google Scholar 

  37. Guidotti, A., Badiani, G., and Giotti, A., 1971, Potentiation by taurine of inotropic effects of straphanthin-K on guinea-pig isolated auricles, Pharmacol. Res. Comm. 3:29–38.

    Article  CAS  Google Scholar 

  38. Guidotti, A., and Giotti, A., 1969. Digitalis inotropic effect on the auricular myocardium of taurine, In: Medicaments et metabolism du myocarde, ed. by D. Lamarche et Royer, Nancy, pp. 487-491.

    Google Scholar 

  39. Guidotti, A., and Giotti, A., 1970, Taurina e sistema cardiovascolare, Recenti Prog. Med. 49:61–97.

    PubMed  CAS  Google Scholar 

  40. Hochachka, P.W., 1986, Defense strategies against hypoxia and hypothermia, Science 231:234–240.

    Article  PubMed  CAS  Google Scholar 

  41. Huxtable, R.J., 1979, Does taurine have a function? TIPS 1:V–VII.

    Google Scholar 

  42. Huxtable, R.J. and Sebring, L.A., 1983, Cardiovascular actions of taurine. In: Sulfur Amino Acids: Biochemical and Clinical Aspects, Liss, A.R., Inc., New York, pp. 5–37.

    Google Scholar 

  43. Huxtable, R.J., Laird II, H.E., and Lippincott, S.E., 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharmacol. Exp. Ther. 211:465–470.

    PubMed  CAS  Google Scholar 

  44. Jacobsen, J.G., and Smith, L.H., Jr., 1968, Biochemistry and physiology of taurine and taurine derivatives, Physiol. Rev. 48:424–491.

    PubMed  CAS  Google Scholar 

  45. Koechlin, B.A., 1954. Isethionic acid, the major anion in axoplasm of squid giant nerve, Federation Proc. 13:80.

    Google Scholar 

  46. Levi, R., and Giotti, A., 1967, Effect of Histamine on sinoatrial node cells of rabbit heart, Experientia 23:1–4.

    Article  Google Scholar 

  47. Masini, E., Failli, P., Baccaro, C, Franconi, F., and Giotti, A., Unpublished results.

    Google Scholar 

  48. Matucci, R., Bennardini, F., Sciammarella, M.L., Baccaro, C, Stendardi, I., Franconi, F., and Giotti, A., 1983, H-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart, 1987, Biochem. Pharmacol., 36:1059–1062.

    Article  Google Scholar 

  49. McBroom, M.J., and Welty, J.D., 1977, Effects of taurine on heart calcium in the cardiomyopathic hamster, J. Mol. Cell. Cardiol 9:853–858.

    Article  PubMed  CAS  Google Scholar 

  50. Montanini, R., Zibetti, A., and Gasco, P., 1971, Osservazioni preliminari sull’impiego della taurina nel trattamento delle vasculopatie cerebrali, Clin. Ter. 59:321–329.

    PubMed  CAS  Google Scholar 

  51. Read, W.O., and Welty, J.D., 1965, Taurine as a regulator of cell potassium in the heart. In: Electrolytes and Cardiovascular Diseases, Ed. by E. Bajusz, S. Karger, Press Basel, New York, pp. 70–85.

    Google Scholar 

  52. Roe, D.A., 1966, Taurine intolerance in psoriasis, J. Invest. Derm. 46:420–430.

    PubMed  CAS  Google Scholar 

  53. Schmidt, C.L.A., Von Adelung, E., and Watson, T., 1981, On the elimination of taurine administered to man, J. Biol. Chem. 33:501–503.

    Google Scholar 

  54. Thurston, J.H., Hauhart, R.E., and Naccarato, E.F., 1981, Taurine: possible role in osmotic regulation of mammalian heart, Science 214:1373–1374.

    Article  PubMed  CAS  Google Scholar 

  55. Sicuteri, F., Fanciullacci, N., Franchi, G., Giotti, A., and Guidotti, A., 1970, Taurine as a therapeutic agent in vascular pain, Clin. Med. 77:21–32.

    Google Scholar 

  56. Welty, J.D., and McBroom, M.J., 1985, Effects of verapamil and taurine administration on heart taurine and calcium in bio 14.6 cardiomyopathic hamsters, Res. Comm. Chem. Path. Pharmao. 49:141–144.

    CAS  Google Scholar 

  57. Welty, J.D., and Read, W.O., 1964, Studies on some cardiac effects of taurine, J. Pharmacol. Exp. Ther. 144:110–115.

    PubMed  CAS  Google Scholar 

  58. Zanelli, G., Ferrero, S., and Patrone, P., 1971, La taurina nella terapia delle arteriopatie obliteranti degli arti inferior!, Nota I. Risultati clinici nei diversi stadi evolutivi, Minerva Cardioangiol 19:605–615.

    PubMed  CAS  Google Scholar 

  59. Zanelli, G., Quaglia, A., and Zino, P., 1971, La taurina nella terapia delle arteriopatie obliteranti degli arti inferiori, Nota II. Variazioni emossimetriche nei diversi stadi evolutivi, Minerva Cardioangiol. 19:616–619.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preclinical and Clinical Pharmacology “Mario Aiazzi Mancini”, University of Florence, viale G.B. Morgagni 65, 50134, Florence, Italy

    Alberto Giotti

Authors
  1. Alberto Giotti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA

    Ryan J. Huxtable

  2. Cattedra di Saggi e Dosaggi Farmacologici, Facolta di Farmacia, Universita di Sassari, Via Muroni, 23, Sassari, Italy

    Flavia Franconi

  3. Department of Preclinical and Clinical Pharmacology “Mario Aiazzi Manzini”, Universita di Firenze, Firenze, Italy

    Alberto Giotti

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Giotti, A. (1987). Cardiovascular Pharmacology and Experimental Therapeutics of Taurine and Related Compounds. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0405-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0407-2

  • Online ISBN: 978-1-4899-0405-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation