Abstract
Chronic infection with hepatitis B virus (HBV) may lead to the development of chronic hepatitis (both chronic persistent and chronic active), post-necrotic cirrhosis and primary hepatocellular carcinoma (PHC). This statement, which does not sound particularly revolutionary now, is directly contrary to the consensus of experts circa 1960 (1). At that time, it was thought that neither infectious nor serum hepatitis (the terms used then) led to chronic liver disease. Chronic hepatitis and cirrhosis, it was thought, were caused by autoimmune or toxic reactions to unidentified agents.
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© 1984 Springer Science+Business Media New York
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London, W.T. (1984). Medical Consequences of the Carrier State. In: Millman, I., Eisenstein, T.K., Blumberg, B.S. (eds) Hepatitis B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0369-3_4
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DOI: https://doi.org/10.1007/978-1-4899-0369-3_4
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