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Vibrio cholerae

Molecular Pathogenesis, Immune Response, and Vaccine Development

  • Chapter
Enteric Infections and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

The curved, gram-negative bacterium Vibrio cholerae is the cause of cholera, a severe and potentially lethal diarrheal disease. The disease has been recognized since ancient times and descriptions of cholera can be found in Sanskrit texts dating back to 500 B.C. (1) Besides its often dramatic clinical presentation, two epidemiologic features distinguish cholera from other diarrheal diseases. These are the tendency of cholera to appear in explosive outbreaks and its predilection for pandemic spread. The explosiveness of a cholera outbreak was sadly witnessed in 1994 with the massive death counts in the refugee camps of Goma, Zaire.

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  1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Matthew K. Waldor & John J. Mekalanos

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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Lois J. Paradise  & Herman Friedman  & 

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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Waldor, M.K., Mekalanos, J.J. (1996). Vibrio cholerae. In: Paradise, L.J., Bendinelli, M., Friedman, H. (eds) Enteric Infections and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0313-6_3

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  • DOI: https://doi.org/10.1007/978-1-4899-0313-6_3

  • Publisher Name: Springer, Boston, MA

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