Abstract
The bursa of Fabricius is the site of primary B cell development in birds, and has been reviewed extensively elsewhere1–3. It is productively colonized during embryonic life by a small number (<50,000) of B lineage committed precursors which undergo immunoglobulin gene rearrangements either prior to their migration to the bursa or within the bursal rudiment during a short window of time in embryonic development. By about day 18 of embryonic development (day e18) all Ig gene rearrangements in the chicken have been completed and the adult B cells compartment is derived from this small pool of rearranged B cell precursors4.
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Jacobsen, K.A., Paramithiotis, E., Ewert, D.L., Ratcliffe, M.J.H. (1996). Apoptotic Cell Death in the Chicken Bursa of Fabricius. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_17
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