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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 pp 253–268Cite as

Overview of Tumor-Inhibiting Non-Platinum Compounds

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Abstract

Cancer mortality in the western world is still on the increase today. In the last few decades, platinum and other metal coordination compounds have been the subject of numerous investigations in the field of cancer chemotherapy. Cisplatin and its derivatives feature prominently here (Figure 1)1,2,3,4. One of the reasons why tumor-inhibiting non-platinum compounds are receiving increasing attention is the fact that cisplatin and other platinum complexes have a relatively limited spectrum of indication. Cisplatin shows its best activity in testicular carcinomas and has good activity in ovarian carcinomas, tumors of the head and neck and bladder tumors2,3,4. It is not, or only insufficiently, active against the tumors that account for the major share of cancer mortality today, such as tumors of the lung and the gastrointestine. The synthesis of new compounds which are active in these platinum-resistant tumors must therefore be one of the aims in inorganic chemistry.

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Author information

Authors and Affiliations

  1. Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, D-69120, Heidelberg, Germany

    Bernhard K. Keppler & Ellen A. Vogel

Authors
  1. Bernhard K. Keppler
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  2. Ellen A. Vogel
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Editor information

Editors and Affiliations

  1. Free University, Amsterdam, The Netherlands

    H. M. Pinedo

  2. Netherlands Cancer Institute, Amsterdam, The Netherlands

    J. H. Schornagel

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© 1996 Springer Science+Business Media New York

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Keppler, B.K., Vogel, E.A. (1996). Overview of Tumor-Inhibiting Non-Platinum Compounds. In: Pinedo, H.M., Schornagel, J.H. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0218-4_24

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  • DOI: https://doi.org/10.1007/978-1-4899-0218-4_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0220-7

  • Online ISBN: 978-1-4899-0218-4

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