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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2 pp 1–16Cite as

NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids

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Abstract

In this paper we illustrate how NMR spectroscopy can provide new insights into the mechanism of action of platinum anticancer drugs, including the detection of intermediates in DNA platination reactions and metabolites in body fluids. The use of modern inverse detection methods and pulsed field gradients in particular now allows work to be carried out on intact biological samples at concentrations of physiological relevance.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Birkbeck College, University of London, Gordon House and Christopher Ingold Laboratories, 29 Gordon Square, London, WC1H 0PP, UK

    Kevin J. Barnham, Zijian Guo, Piedad del Socorro Murdoch & Peter J. Sadler

  2. School of Science, Griffith University, Nathan, Brisbane, Australia, 4111

    Susan J. Berners-Price

Authors
  1. Kevin J. Barnham
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  2. Susan J. Berners-Price
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  3. Zijian Guo
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  4. Piedad del Socorro Murdoch
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  5. Peter J. Sadler
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Editor information

Editors and Affiliations

  1. Free University, Amsterdam, The Netherlands

    H. M. Pinedo

  2. Netherlands Cancer Institute, Amsterdam, The Netherlands

    J. H. Schornagel

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© 1996 Springer Science+Business Media New York

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Barnham, K.J., Berners-Price, S.J., Guo, Z., del Socorro Murdoch, P., Sadler, P.J. (1996). NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids. In: Pinedo, H.M., Schornagel, J.H. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0218-4_1

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  • DOI: https://doi.org/10.1007/978-1-4899-0218-4_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0220-7

  • Online ISBN: 978-1-4899-0218-4

  • eBook Packages: Springer Book Archive

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