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Potential Role of Hyperactivation of Signal Transduction Pathways in Alzheimer’s Disease: Protein Kinase C Regulates PHF-like Phosphorylation of Tau within Neuronal Cells

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Abstract

Paired helical filaments (PHF) that accumulate in affected neurons in Alzheimer’s disease are comprised of hyperphosphorylated tau that exhibits electrophoretic and antigenic properties distinct from that of normal adult CNS tau (for reviews, see refs. 1–3). Accordingly, one approach towards understanding the onset and progression of Alzheimer’s disease is to determine the kinase(s) responsible for phosphorylating tau.

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Authors and Affiliations

  1. Center for Cellular Neurobiology and Neurodegeneration Research, University of Massachusetts at Lowell, Lowell, MA, 01854, USA

    Thomas B. Shea, John J. Boyce & Corrine M. Cressman

  2. Department of Biological Sciences, University of Massachusetts at Lowell, Lowell, MA, 01854, USA

    Thomas B. Shea & John J. Boyce

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  1. Thomas B. Shea
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  2. John J. Boyce
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  3. Corrine M. Cressman
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  1. The George Washington University Medical Center, Washington, D.C., USA

    Gary Fiskum

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Shea, T.B., Boyce, J.J., Cressman, C.M. (1996). Potential Role of Hyperactivation of Signal Transduction Pathways in Alzheimer’s Disease: Protein Kinase C Regulates PHF-like Phosphorylation of Tau within Neuronal Cells. In: Fiskum, G. (eds) Neurodegenerative Diseases. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0209-2_54

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  • DOI: https://doi.org/10.1007/978-1-4899-0209-2_54

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