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Mechanisms of Selective Neuronal Vulnerability to 1-Methyl-4-Phenylpyridinium (MPP+) Toxicity

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Neurodegenerative Diseases

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Abstract

A common feature of neurodegenerative diseases such as Parkinson’s disease is the selective, inappropriate death of specific populations of central neurons. In Parkinson’s disease, dopaminergic neurons are lost in the zona compacta of the substantia nigra.1 This selective neuronal death gives rise to a progressive movement disorder whose cause is unknown and for which there is no known cure.

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Author information

Authors and Affiliations

  1. Departments of Neurology and Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA

    Patricia A. Trimmer

  2. Departments of Urology and Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA

    Jeremy B. Tuttle

  3. Department of Neurosurgery, University of Virginia, Charlottesville, VA, 22908, USA

    Jason P. Sheehan

  4. Department of Neurology, University of Virginia, Charlottesville, VA, 22908, USA

    James P. Bennett Jr.

Authors
  1. Patricia A. Trimmer
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  2. Jeremy B. Tuttle
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  3. Jason P. Sheehan
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  4. James P. Bennett Jr.
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Editor information

Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Gary Fiskum

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© 1996 Springer Science+Business Media New York

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Trimmer, P.A., Tuttle, J.B., Sheehan, J.P., Bennett, J.P. (1996). Mechanisms of Selective Neuronal Vulnerability to 1-Methyl-4-Phenylpyridinium (MPP+) Toxicity. In: Fiskum, G. (eds) Neurodegenerative Diseases. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0209-2_53

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  • DOI: https://doi.org/10.1007/978-1-4899-0209-2_53

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0211-5

  • Online ISBN: 978-1-4899-0209-2

  • eBook Packages: Springer Book Archive

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