Abstract
Apolipoprotein E (apo E) is a cholesterol transport protein that is present both in blood as well as in central nervous system, where its levels increase following nerve injury. Presumably the function of apo E is to facilitates lipid uptake1. In the periphery, apo E is synthesized by the liver and taken up throughout the body via low density lipoprotein receptors1. In the central nervous system, apo E is synthesized by astrocytes and microglial cells following nerve injury1. Apo E avidly binds lipids, in particular cholesterol, and it is taken up by the axon during regeneration2. Thus, the action of apo E plays an important role in the ability of the brain to cope with neuronal injury. This role may also be critical in the ability of the brain to cope with a neurodegenerative illness, such as Alzheimer’s disease.
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© 1996 Springer Science+Business Media New York
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Wolozin, B., Basaric-Keys, J., Canter, R., Li, Y., Strickland, D., Sunderland, T. (1996). Differential Regulation of APP Secretion by Apolipoprotein E3 and E4. In: Fiskum, G. (eds) Neurodegenerative Diseases. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0209-2_14
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DOI: https://doi.org/10.1007/978-1-4899-0209-2_14
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