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GTP Cyclohydrolase I in Inherited Dystonia and Its Pathophysiological Importance

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The Basal Ganglia V

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 47))

Abstract

Hereditary progressive dystonia with marked diurnal fluctuation (HPD) is an autosomally dominantly inherited postural dystonia with onset in childhood and is characterized by marked diurnal fluctuation of symptoms and marked and sustained response to levodopa without any side effects (Segawa, 1981; Segawa et al., 1986). HPD also has particular neuropathological, neurohistochemical and biochemical characteristics, which demarcate it from torsion dystonia and other levodopa responsive disorders (Segawa and Nomura, 1995).

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Author information

Authors and Affiliations

  1. Segawa Neurological Clinic for Children, Tokyo, Japan

    M. Segawa, Y. Nomura, R. Tanaka, T. Tanaka, Y. Shitaka, F. Okada, N. Nishiyama & H. Fukuda

  2. National Institute of Industrial Health, Kawasaki, Japan

    H. Fukuda

  3. Juntendo University School of Medicine, Tokyo, Japan

    O. Hikosaka

Authors
  1. M. Segawa
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  2. Y. Nomura
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  3. R. Tanaka
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  4. T. Tanaka
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  5. Y. Shitaka
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  6. F. Okada
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  7. N. Nishiyama
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  8. H. Fukuda
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  9. O. Hikosaka
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Editor information

Editors and Affiliations

  1. Gunma University, Maebashi, Gunma, Japan

    Chihiro Ohye

  2. Osaka University, Toyonaka, Osaka, Japan

    Minoru Kimura

  3. The University of Melbourne, Parkville, Victoria, Australia

    John S. McKenzie

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© 1996 Springer Science+Business Media New York

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Segawa, M. et al. (1996). GTP Cyclohydrolase I in Inherited Dystonia and Its Pathophysiological Importance. In: Ohye, C., Kimura, M., McKenzie, J.S. (eds) The Basal Ganglia V. Advances in Behavioral Biology, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0194-1_56

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  • DOI: https://doi.org/10.1007/978-1-4899-0194-1_56

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  • Online ISBN: 978-1-4899-0194-1

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