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Modulation of Wound Repair by Members of the Fibroblast Growth Factor Family

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

The fibroblast growth factors (FGFs) comprise a family of at least nine structurally homologous polypeptides that are found in a variety of cells and tissues (Baird and Böhlen, 1990; Brem and Klagsbrun, 1993; Burgess and Maciag, 1989; Folkman and Klagsbrun, 1987; Klagsbrun, 1989; Klagsbrun and D’Amore, 1991; Klagsbrun and Folkman, 1990; Rifkin and Moscatelli, 1989; Tanaka et al., 1992; Miyamoto et al., 1993). This family includes acidic FGF (aFGF), basic FGF (bFGF), int-2 protein, HST/K-FGF, FGF-5, FGF-6, keratinocyte growth factor (KGF), androgen-induced growth factor (AIGF), and glia-activating factor (GAF) (see Table I). These growth factors have been enumerated as FGF-1 through FGF-9, respectively, in order to simplify the nomenclature (Baird and Klagsbrun, 1991). However, since the name KGF is still widely used, the designation “KGF/FGF-7” will be used here in referring to this factor. The aFGF (FGF-1) and bFGF (FGF-2) proteins are the most extensively characterized FGF family members in terms of detailed knowledge concerning structure and biological activity.

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    Judith A. Abraham

  2. Departments of Surgery and Pathology, Children’s Hospital, and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Michael Klagsbrun

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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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© 1988 Springer Science+Business Media New York

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Abraham, J.A., Klagsbrun, M. (1988). Modulation of Wound Repair by Members of the Fibroblast Growth Factor Family. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_6

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  • DOI: https://doi.org/10.1007/978-1-4899-0185-9_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0187-3

  • Online ISBN: 978-1-4899-0185-9

  • eBook Packages: Springer Book Archive

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