Abstract
In high-resolution 1H NMR spectroscopy, malignant glioma tissues are shown to include higher concentration of taurine than normal brain tissues do. Although it is well known that mouse astrocyte18, rat astrocyte5 and glioma cells12 have a high-affinity uptake system for taurine, little is known about such transport in human glioma cells.
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References
Bradford, M. 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal.Biochem. 72:248–254.
Couldwell, W.T., Antel, J.P., and Yong, V.W. 1992, Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of gioma mitogens and modulators of protein kinase C,? 31:717–724.
Couldwell, W.T., Uhm, J.H., Antel, J.P., and Yong, V.W. 1991, Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro, Neurosurgery, 29:880–886.
Crabai, F., Sitzia, A., and Pepeu, G. 1974, Taurine concentration in the neurohypophysis of different animal species, J.Neurochem. 23:1091–1092.
Holopainen, L. and Kontro, P. 1986, High-affinity uptake of taurine and beta-alanine in primary cultures of rat astrocytes, Neurochem.Res. 11:207–215.
Huxtable, R.J. 1989, Taurine in the central nervous system and the mammalian actions of taurine, Prog.Neurobiol. 32:471–533.
Jhiang, S.M., Fithian, L., Smanik, P., McGill, J., Tong, Q., and Mazzaferri, E.L. 1993, Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells, FEES Lett. 318:139–144.
Jones, D.P., Miller, L.A., Dowling, C., and Chesney, R.W. 1991, Regulation of taurine transporter activity in LLC-PK1 cells: role of protein synthesis and protein kinase C activation, J.Am.Soc.Nephrol. 2:1021–1029.
Kraft, A.S., Anderson, W.B., Cooper, H.L., and Sando, J.J. 1982, Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells, J.Biol.Chem. 257:13193–13196.
Kulanthaivel, P., Cool, D.R., Ramamoorthy, S., Mahesh, V.B., Leibach, F.H., and Ganapathy, V. 1991, Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line, Biochem.J. 277:53–58.
Liu, Q.-R., López-Corcuera, B., Nelson, H., Mandiyan, S., and Nelson, N. 1992, Cloning and expression of a cDNA encoding the transporter of taurine and β-alanine in mouse brain, Proc.Natl.Acad.Sci.USA, 89:12145–12149.
Martin, D.L. and Shain, W. 1979, High affinity transport of taurine and β-alanine and low affinity transport of τ-aminobutyric acid by a single transport system in cultured glioma cells, J.Biol.Chem. 254:7076–7084.
Moreno, A., Rey, M., Montane, J.M., Alonso, J., and Arus, C. 1993, 1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethyleneglycol absorption in tumors may have diagnostic significance, NMR Biomed, 6:111–118.
Nakamura, H., Huang, S.H., and Takakura, K. 1993, Phorbol ester increases the efflux of endogenous taurine from C6 glioma cells, Neurochem.Res. 18:851
Peeling, J. and Sutherland, G. 1992, High-resolution 1H NMR spectroscopy studies of extracts of human cerebral neoplasms, Magn.Resort.Med. 24:123–136.
Philibert, R. A. and Dutton, G.R. 1988, Phorbol ester and dibutyryl cyclic AMP reduce content and efflux of taurine in primary cerebellar astrocytes in culture, Neuroscience Letters, 95:323–328.
Pontén, J. 1975, Neoplastic human glia cells in culture, in: “Human Tumor Cells In vitro”, Fogh, J. ed., Plenum Publishing Corp. New York, pp. 175–206.
Schousboe, A., Fosmark, H., and Svenneby, G. 1976, Taurine uptake in astrocytes cultured from dissociated mouse brain hemispheres, Brain Res. 116:158–164.
Smith, K.E., Borden, L.A., Wang, C.-H.D., Hartig, PR., Branchek, T.A., and Weinshank, R.L. 1992, Cloning and expression of a high affinity taurine transporter from rat brain, Mol.Pharmacol. 42:563–569.
Starr, M.S. 1978, Uptake of taurine by retina in different species, Brain Res. 151:604–608.
Wright, C.E., Tallan, H.H., Lin, Y.Y., and Gaull, G.E. 1986, Taurine: biological update, Ann.Rev.Biochem. 55:427–453.
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Nakamura, H., Huang, S.H., Takakura, K. (1996). High-Affinity Taurine Uptake and Its Regulation by Protein Kinase C in Human Glioma Cells. In: Huxtable, R.J., Azuma, J., Kuriyama, K., Nakagawa, M., Baba, A. (eds) Taurine 2. Advances in Experimental Medicine and Biology, vol 403. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0182-8_40
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DOI: https://doi.org/10.1007/978-1-4899-0182-8_40
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