Skip to main content
SpringerLink
Log in

Fluoride and Bone

Toxic Effects and Therapeutic Role

  • Chapter
Therapeutic Uses of Trace Elements

  • 204 Accesses

Abstract

Trace elements have an essential effect in minute doses, in contrast with other elements such as calcium and phosphorus that are necessary to the organism in large amounts. However, trace elements may be very toxic when present in large amounts. Thus, the effects of trace elements may be considered as physiological manifestations caused by very small amounts of substances which are toxic at higher concentrations. The wide distribution of fluoride (F) in food and water, plants and animals, as well as in human tissues, suggests that fluoride must have a definite physiological effect. Fluoride is present in the hard and soft tissues of the body in extremely small amounts of the same order of magnitude as other essential trace elements (1). The metabolism and toxicity of fluoride have been reviewed by Whitford (2) and Jenkins (3). Fluoride is necessary for the human organism and plays a role in controlling certain enzymatic reactions in various organs. Rapidly excreted from the body, the main retention sites for fluoride are calcified tissues. This retention depends on the quantity of fluoride administered or ingested, on the bioavailability of the fluoride salt used, as well as on the duration of exposure to fluoride.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. W. Mertz, Science 213, 1332–1338 (1981).

    Article  CAS  Google Scholar 

  2. G.M. Whitford, The metabolism and toxicity of fluoride, Karger, Basel (1989).

    Google Scholar 

  3. G.N. Jenkins, in Trace Metals and Fluoride in Bones and Teeth, N.D. Priest, F.L. van de Vyver eds., CRC Press, Boca Raton, pp. 141–173 (1990).

    Google Scholar 

  4. G. Boivin, P. Chavassieux, M.C. Chapuy, C.A. Baud, P.J. Meunier, Bone, 10, 89–99 (1989).

    Article  CAS  Google Scholar 

  5. G. Boivin, P. Chavassieux, M.C. Chapuy, C.A. Baud, P.J. Meunier, J. Bone Miner. Res. 5 suppl 1, S185–S189 (1990).

    Google Scholar 

  6. G. Boivin, P.J. Meunier, in The Metabolic and Molecular Basis of Acquired Disease, R.D. Cohen, B. Lewis, K.G.M.M. Alberti, A.M. Denman eds., Baillière Tindall, London, pp. 1803–1823 (1990).

    Google Scholar 

  7. G. Boivin, P. Chavassieux, M.C. Chapuy, C.A. Baud, P.J. Meunier, Pathol. Biol. 34, 33–39 (1986).

    CAS  Google Scholar 

  8. C.A. Baud, R. Lagier, G. Boivin, M.A. Boillat, Virchows Arch. Pathol. Anat. Histol. 380, 283–297 (1978).

    Article  CAS  Google Scholar 

  9. S.P.S. Teotia, M. Teotia, N.P.S. Teotia, Fluoride 9, 91–98 (1976).

    Google Scholar 

  10. S.P.S. Teotia, M. Teotia, and D.P. Singh, in Fluoride Research 1985, Studies in Environmental Science, H. Tsunoda, M.H. Yu eds., Elsevier, Amsterdam, pp. 347–355 (1986).

    Google Scholar 

  11. C. Rich, F. Ensinck, Nature 191, 184–185 (1961).

    Article  CAS  Google Scholar 

  12. N. Mamelle, P.J. Meunier, R. Dusan, M. Guillaume, J.L. Martin, A. Gaucher, A. Prost, G. Zeigler, P. Netter, Lancet ii, 361–364 (1988).

    Article  Google Scholar 

  13. B.L. Riggs, S.F. Hodgson, W.M. O’Fallon, E.Y.S. Chao, H.W. Wahner, J.M. Muhs, S.L. Cedel, L.J. Melton III, N. Engl. J. Med. 322, 802–809 (1990).

    Article  CAS  Google Scholar 

  14. B.L. Riggs, W.M. O’Fallon, S.F. Hodgson, E.Y.S. Chao, H.W. Wahner, J.M. Muhs, L.J. Melton III, Bone Mineral 17 suppl. 1, 74 (1992).

    Article  Google Scholar 

  15. G.S. Rao, Annu. Rev. Nutr. 4, 115–136(1984).

    Article  CAS  Google Scholar 

  16. G.E. Smith, Xenobiotica 15, 177–186 (1985).

    Article  CAS  Google Scholar 

  17. L. Singer, R. Ophaug, C.R.C. Crit. Rev. Clin. Lab. Sci. 18, 111–140 (1982).

    Article  CAS  Google Scholar 

  18. G. Boivin, B. Grousson, R J. Meunier, J. Bone Miner. Res. 6, 1183–1190 (1991).

    Article  CAS  Google Scholar 

  19. S. Bang, C.A. Baud, J. Bone Miner. Res. 5 suppl. 1, S87–S89 (1990).

    Google Scholar 

  20. C.A. Baud, S. Bang, in Fluoride in Medicine, T.L. Vischer ed., Huber, Bern, pp. 27–36 (1970).

    Google Scholar 

  21. C.A. Baud, S. Bang, J.M. Very, J. Biol. Buccale 5, 195–202 (1977).

    CAS  Google Scholar 

  22. G. Boivin, RJ. Meunier, Res. Clin. Forums 15, 13–19 (1993).

    Google Scholar 

  23. M.D. Grynpas, J. Bone Miner. Res. 5 suppl. 1, S169–S175 (1990).

    CAS  Google Scholar 

  24. G. Boivin, M.C. Chapuy, C.A. Baud, P.J. Meunier, J. Bone Miner. Res. 3, 497–502 (1988).

    Article  CAS  Google Scholar 

  25. C.H. Turner, G. Boivin, P.J. Meunier, Calcif. Tissue Int. 52, 130–138 (1993).

    Article  CAS  Google Scholar 

  26. Y. Suzuki, TohokuJ. Exp. Med. 129, 327–336 (1979).

    Article  CAS  Google Scholar 

  27. R.D. van Kesteren, S.A. Duursma, W.J. Visser, J. van der Sluys Veer, O. Backer Dirks, Metab. Bone Dis. Rel. Res. 4, 31–37(1982).

    Article  Google Scholar 

  28. B. Courvoisier, C.A. Baud, J.M. Very, A. Assimacopoulos, HJ. Tochon-Danguy, G. Boivin, A. Donath, J. Garcia, A. Gasser, J. Fischer, S. Korol, P. Burckhardt, Schweiz. Med. Wochenschr. 115, 922–931 (1985).

    CAS  Google Scholar 

  29. J.C. Gerster, S.A. Charhon, P. Jaeger, G. Boivin, D. Briançon, A. Rostan, C.A. Baud, P.J. Meunier, Br. Med. J. 287, 723–725(1983).

    Article  CAS  Google Scholar 

  30. J.A. Kanis, P.J. Meunier, Q. J. Med. 210, 145–164 (1984).

    Google Scholar 

  31. E.D. Eanes, A.H. Reddi, Metab. Bone Dis. Rel. Res. 2,3–10(1979).

    Article  CAS  Google Scholar 

  32. N.C. Blumenthal, in Trace Metals and Fluoride in Bones and Teeth, N.D. Priest, F.L. van De Vyver eds., CRC Press, Boca Raton, pp. 307–313 (1990).

    Google Scholar 

  33. M.D. Grynpas, P.T. Cheng, Bone Mineral 5, 1–9 (1988).

    Article  CAS  Google Scholar 

  34. G. Boivin, J. Duriez, M.C. Chapuy, B. Flautre, P. Hardouin, P.J. Meunier, Osteoporosis Int. 3, 204–208 (1993).

    Article  CAS  Google Scholar 

  35. D. Briançon, P.J. Meunier, Orthop. Clin. North Am. 12, 629–648 (1981).

    Google Scholar 

  36. M.W. Lundy, DJ. Baylink, S.F. Hodgson, B.L. Riggs, J. Bone Miner. Res. 2 suppl. 1, 379 (1987).

    Google Scholar 

  37. R.R. Recker, D.B. Kimmel, J.C. Gallagher, A. Vaswani, J. Aloia, J. Bone Miner. Res. 2 suppl. 1, 381 (1987).

    Google Scholar 

  38. J.R. Farley, J.E. Wergedal, D.J. Baylink, Science 22, 330–332 (1983).

    Article  Google Scholar 

  39. M.W. Lundy, J.R. Farley, D.J. Baylink, Bone 7, 289–293 (1986).

    Article  CAS  Google Scholar 

  40. H.E. Gruber, DJ. Baylink, Clin. Orthop. 267, 264–277 (1991).

    Google Scholar 

  41. P. Chavassieux, G. Boivin, CM. Serre, P.J. Meunier, Bone 14, 721–725 (1993).

    Article  CAS  Google Scholar 

  42. W.K.H. Lau, J.R. Farley, T.K. Freeman, DJ. Baylink, Metabolism 38, 858–868 (1989).

    Article  CAS  Google Scholar 

  43. B.Y Reed, J.E. Zerwekh, P.P. Antich, C.Y.C. Pak, J. Bone Miner. Res. 8, 19–25 (1993).

    Article  CAS  Google Scholar 

  44. J. Caverzasio, T. Imaï, P. Ammann, D. Burgener, J.R Bonjour, J. Bone Miner. Res. 11, 46–55 (1996).

    Article  CAS  Google Scholar 

  45. DJ. Baylink, P.B. Duane, S.M. Farley, J.R. Farley, Caries Res. 17 suppl 1, 56–76 (1983).

    Article  CAS  Google Scholar 

  46. E. Zeiger, M.D. Shelby, K.L. Witt, Environ. Mol. Mutagen. 21, 309–318 (1993).

    Article  CAS  Google Scholar 

  47. P. Grandjean, J.H. Olsen, O.M. Jensen, K. Juel, J. Natl. Cancer Inst. 84, 1903–1909 (1992).

    Article  CAS  Google Scholar 

  48. J.M. Faccini, S.P.S. Teotia, Calcif. Tissue Res. 16, 45–57 (1974).

    Article  CAS  Google Scholar 

  49. F. Manji, S. Kapila, Odontostomatol Trop. 9, 15–20 and 71-75 (1986).

    CAS  Google Scholar 

  50. Y. Haikel, J.C. Voegel, R.M. Frank, Arch. Oral Biol. 31, 279–286 (1986).

    Article  CAS  Google Scholar 

  51. M.A. Boillat, C.A. Baud, R. Lagier, J. Garcia, P. Rey, S. Bang, G. Boivin, C. Demeurisse, M. Gössi, H.J. Tochon-Danguy, J.M. Very, P. Burckhardt, B. Voinier, A. Donath, B. Courvoisier, Schweiz. Med. Wochenschr. 109 suppl 8, 1–28(1979).

    Google Scholar 

  52. P. Grandjean, Am. J. Ind. Med. 3, 227–236 (1982).

    Article  CAS  Google Scholar 

  53. P. Grandjean, G. Thomsen, Br. J. Ind Med. 40, 456–461 (1983).

    CAS  Google Scholar 

  54. P.J. Meunier, P. Courpron, J.S. Smoller, D. Briançon, Clin. Orthop. 148, 304–309 (1980).

    Google Scholar 

  55. P.J. Klemmer, N.M. Hadler, Ann. Int. Med. 89, 607–611 (1978).

    Article  CAS  Google Scholar 

  56. J.R. Fisher, M.L. Sievers, R.T. Takeshita, H. Caldwell, Arizona Med. 38, 833–835 (1981).

    CAS  Google Scholar 

  57. A. Mithal, N. Trivedi, S.K. Gupta, S. Kumar, R.K. Gupta, Skeletal Radiol. 22, 257–261 (1993).

    Article  CAS  Google Scholar 

  58. Y Wang, Y Yin, L.A. Gilula, AJ. Wilson, Amer. J. Roentgenol. 162, 93–98 (1994).

    Article  CAS  Google Scholar 

  59. I. Arnala, E.M. Alhava, P. Kauranen, Acta Orthop. Scand. 56, 161–166 (1985).

    Article  CAS  Google Scholar 

  60. Y Ericsson, J. Dental Res. 59 DII, 2131–2136 (1980).

    Google Scholar 

  61. G.K. Stookey, P.F. DePaola, J.D.B. Featherstone, O. Fejerskov, IJ. Möller, S. Rotberg, K.W. Stephen, J.S. Wefel, Caries Res. 27, 337–360 (1993).

    Article  CAS  Google Scholar 

  62. B.L. Riggs, in Bone and Mineral Research, Annual 2, W.A. Peck ed., Elsevier, Amsterdam, pp. 366–393 (1983).

    Google Scholar 

  63. G. Boivin, J. Dupuis, P.J. Meunier, in Nutrition and Osteoporosis, A. Simopoulos, C. Galli eds. World Rev. Nutr. Diet. vol. 73, Karger, Basel, pp. 80–103 (1993).

    Google Scholar 

  64. Y. Ericsson, Caries Res. 17 suppl. 1, 46–55 (1983).

    Article  CAS  Google Scholar 

  65. P. Arnold, M. Wermeille, M.C. Chapuy, J. Biollaz, E.M. Grandjean, J.L. Schelling, P.J. Meunier, Bone 10, 401–407 (1989).

    Article  CAS  Google Scholar 

  66. F. Lioté, C. Bardin, A. Liou, A. Brouard, J.L. Terrier, D. Kuntz, Calcif. Tissue Int. 50, 209–213 (1992).

    Article  Google Scholar 

  67. M. Kleerekoper, R. Balena, J. Foldes, M.S. Shih, D. Rao, A.M. Parfitt, J. Bone Miner. Res. 5 suppl. 2, S140 (1990).

    Google Scholar 

  68. C.Y.C. Pak, K. Sakhaee, C. Gallagher, C. Parcel, R. Petersen, J.E. Zerwekh, M. Lemke, F. Britton, M.C. Hsu, B. Adams, J. Bone Miner. Res. 1, 563–571 (1986).

    Article  CAS  Google Scholar 

  69. B.L. Riggs, D.J. Baylink, M. Kleerekoper, J.M. Lane, L.J. Melton III, P.J. Meunier, J. Bone Miner. Res. 2, 123–126(1987).

    Article  CAS  Google Scholar 

  70. P. Charles, L. Mosekilde, F. Taagehoj Jensen, Bone 6, 201–206 (1985).

    Article  CAS  Google Scholar 

  71. M.W. Lundy, M. Stauffer, J.E. Wergedal, D.J. Baylink, J.D.B. Featherstone, S.F. Hodgson, B.L. Riggs, Osteoporosis Int. 5, 115–129 (1995).

    Article  CAS  Google Scholar 

  72. M.P. Whyte, M.A. Bergfeld, W.A. Murphy, L.V. Avioli, S.L. Teitelbaum, Am. J. Med. 72, 193–202 (1982).

    Article  CAS  Google Scholar 

  73. V.J. Vigorita, M.K. Suda, Clin. Orthop. 177, 274–282 (1983).

    Google Scholar 

  74. S.A. Duursma, J.H. Glerum, A. van Dijk, R. Bosch, H. Kerkhoff, J. van Putten, J.A. Raymakers, Bone 8, 131–136(1987).

    Article  CAS  Google Scholar 

  75. P.J. Marie, M.C. de Vernejoul, A. Lomri, J. Bone Miner. Res. 7, 103–113 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM Unité 403, Faculté A. Carrel, 69372, Lyon Cedex 08, France

    Georges Boivin & Pierre J. Meunier

Authors
  1. Georges Boivin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre J. Meunier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Free University of Brussels, Brussels, Belgium

    Jean Nève

  2. Lariboisière Hospital, Paris, France

    Philippe Chappuis

  3. National Institute for Agronomic Research, Theix, France

    Michel Lamand

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Boivin, G., Meunier, P.J. (1996). Fluoride and Bone. In: Nève, J., Chappuis, P., Lamand, M. (eds) Therapeutic Uses of Trace Elements. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0167-5_49

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0167-5_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0169-9

  • Online ISBN: 978-1-4899-0167-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation