Abstract
Plasminogen activator inhibitor-1 (PAI-1) is a single chain glycoprotein of approximately 50,000 Daltons which is synthesized by endothelial cells and hepatocytes. It is one of the many factors that endothelial cells (EC) secrete which are involved intimately in the maintenance of the haemostatic balance. In malignant states, especially those with widespread metastasis, this balance is frequently upset with a resulting increase in thromboembolic events. There is not one single easily identifiable pattern of changes that accounts for this increased risk, but disruption of the fibrinolytic system, in particular an increase in circulating PAI-1 concentration, is a common finding in patients with cancer. We wanted to assess the degree to which this might be due to an effect of malignant cells upon EC PAI-1 production.
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References
Declerck PJ, et al. Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Blood 71(1):220, 1988.
Nand S, et al. Hemostatic abnormalities in untreated cancer: incidence and correlation with thrombotic and hemorrhagic complications. J Clin Oncol 5(12): 1998, 1987.
Zurbon KH, et al. Investigations of coagulation of system and fibrinolysis in patients with disseminated adenocarcinomas and non-Hodgkin’s lymphomas. Oncology 47(5): 376, 1990.
Mannucci PM, et al. Changes in fibrinolysis in patients with localized tumors. Eur J Cancer 26(2): 83, 1990.
ATCC Cell Lines & Hybridomas, 8th Edition 227, 1994, ATCC HB-8065, (Reference: Nature (Lond.)282:615, 1979.
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Zhen, L.W., Ling, M.C., Wickham, N. (1998). Endothelial Cell PAI-1 Production — Modulation by Malignant Cells in vitro . In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_45
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DOI: https://doi.org/10.1007/978-1-4899-0133-0_45
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