Abstract
Poly(amido-amines) (PAAs) are synthetic polymers characterized by the presence of amido and tertiary amino groups regularly arranged along their macromolecular chain. Therefore, they can be classified as polycations.
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References
Barbucci, R., and Ferruti, P., 1979, Protonation and complex formation of some novel poly(amido-amines), Polymer, 20:1061.
Barbucci, R., Ferruti, P., Micheloni, M., Delfini, M, Segre, A.L., and Conti, F., 1980a, Thermodynamics and C13 n.m.r. data on the protonation of polymeric bases whose repeating units behave independently towards protonation, Polymer, 21:81.
Barbucci, R., Barone, V., Ferruti, P., and Delfini, M., 1980b, Macro-inorganics. Part 3. Chelation of Copper (II) ion with some polymers having a poly(amido-amine) structure and their non-macromolecular models”, J. Chem. Soc. Daltion Transact., 21 253.
Barbucci, R., Casolaro, M., Ferruti, P., Barbone, V., Lelj, F., and Oliva, L., 1981a, Macroinorganics. 7. Property-structure relationships for polymeric bases whose monomeric units behave independently toward protonation, Macromolecules, 14:1203.
Barbucci, R., Barone, V., Ferruti, P., and Oliva, L., 1981b, Thermodynamics of protonation of polymeric bases whose repeating units behave independentely, J. Polymer Sci., Polymer Symp., 69:49.
Barbucci, R., Casolaro, M., Ferruti, P., and Barone, V., 1982a, Macroinorganics. 8. Chelation of copper(II) ion with some new poly(amido-amines), Polymer, 23:148.
Barbucci, R., Casolaro, M., Danzo, N., Beni, M.C., Barone, V., and Ferruti, P., 1982b, Thermodynamics of protonation and complex formation of multifunctional polymers, Gazz. Chim. It., 112:105.
Barbucci, R., Casolaro, M., Nocentini, M., Corezzi, S., Ferruti, P. and Barone, V., 1986, Acid-base and metal ion complex formation properties of polymers containing amino acid residues, Macromolecules, 19:37.
Barbucci, R., Ferruti, P., Improta, C, La Torraca, M., Oliva, L., and Tanzi, M.C., 1979, Macroinorganics — IV — Thermodynamic functions relative to the protonation of poly(amido-amine)s with repeating unit containing amino groups, Polymer, 20,: 1298.
Bignotti, F., Sozzani, P., Ranucci, E., and Ferruti, P., 1994, NMR studies, molecular characterization, and degradation behavior of poly(amido amine)s. 1. Poly(amido amine) deriving from the polyaddition of 2-methylpiperazine to 1,4-bis(acryloyl) piperazine, Macromolecules, 27:171.
Caldwell, G., Neuse, E., and Stephanou, A., 1993, Synthesis of water-soluble poly(amidoamine)s for biomedical applications. II. Polymers possessing interchain-type secondary amino groups suitable for side-chain attachment, J. Appl Polym. Sci., 50:393.
Chu, B.C.F., and Howell, S.B., 1981, Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to third space body compartment, J. Pharmacol. Exp. Ther. 219:389.
Citro, G., Szczylik, C, Ginobbi, P., Zupi, G., and Calabretta, B., 1994, Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells, Br. J. Cancer, 69:463.
Danusso, F., and Ferruti, P., 1970, Synthesis of tertiary amino polymers, Polymer, 11:88.
Duncan, R., 1992, Drug polymer conjugates potential for improved chemotherapy, Anti-Cancer Drugs, 3:175.
Duncan, R., Dimitrijevic, S., and Evagorou, E., 1996, The role of polymer conjugates in the diagnosis and treatment of cancer”, S. T.P. Pharma Sci. 6:237.
Duncan, R., Ferruti, P., Sgouras, D., Tuboku-Metzger, A., Ranucci, E., and Bignotti, F., 1994, A polymer-Triton X-100 conjugate capable of pH-dependent red blood cell lysis: a model system illustrating the possibility of drug delivery within acidic intracellular compartments, J. Drug Targeting, 2:341.
Ferruti, P., and Barbucci, R., 1984, Linear amino polymers: synthesis, protonation, and complex formation, Advanc. Polym. Sci., 58:57.
Ferruti, P., Danusso, F., Franchi, G., Polentarutti, N., and Garattini, S., 1973, Effects of a series of new synthetic high polymers of cancer metastases, J. Medicinal Chem. 16:497.
Ferruti P., 1996, Ion chelating polymers, in: The polymeric materials encyclopedia, J.C. Salamone, ed., CRC Press, Boca Raton.
Ferruti, P., 1985, Poly(amido-amines), Macromol. Syntheses, 9:25.
Ferruti, P., Marchisio, M.A., and Barbucci, R., 1985m Synthesis physico-chemical properties and biomedical applications of poly(amido-amine)s, Polymer, 26:1336.
Ferruti, P., Danzo, N., Oliva, L., Barbucci, R., and Barone, V., 1981, Macro-inorganics. Part 6. Protonation and complex formation of a new series of polymers whose repeating units behave independently, J.Chem. Soc. Dalton, 539.
Ferruti, P., Ranucci, E., Sartore, L., Bignotti, F., Marchisio, M.A., Bianciardi, P., and Veronese, F.M., 1994a, Recent results on functional polymers and macromonomers of interest as biomaterials or for biomaterial modification, Biomaterials, 15:1235.
Ferruti, P., Ranucci, E., Bignotti, F., Sartore, L., Bianciardi, P., and Marchisio, M.A., 1994b, Degradation behaviour of ionic stepwise polyaddition polymers of medical interest, J. Biomat. Sci., Polym. Ed, 6:833.
Huguet, J. and Vert, M., 1985, Partially quaternised poly(tertiary amines) as pH-dependent drug carrier for solubilisation and temporary trapping of liopophilic drug in aqueous media, J. Controlled Rel., 1:217.
Mandel M., 1992, Polyelectrolytes in Encyclopedia of Polymer Science and Technology, H.F. Mark, N.G. Gaylord and N.M. Bikales, eds., Interscience, New York.
Marchisio, M.A., Longo, T., and Ferruti, P., 1973, A selective de-heparinizer filter made of new cross-linked polymers of a poly-amido-amine structure, Experientia, 29:93.
Ranucci, E., and Ferruti, P., 1991, Block copolymers containing poly(ethylene glycol) and poly(amido-amine) or poly(amido-thioether-amine) segments, Macromolecules, 24:3747.
Ranucci, E., Spagnoli, G., Ferruti, P., Sgouras, D., and Duncan, R., 1991, Poly(amidoamine)s with potential as drug carriers: degradation and cellular toxicity, J. Biomat. Sci. Polym. Ed., 2:303.
Richardson, S., Bignotti, F., Ferruti, P., and Duncan, R., 1997, Poly(amido-amines) as potential delivery systems for oligonucleotides, Proceedings of the 2nd International Symposium on Polymer Therapeutics, Kumamoto, April 18–19.
Richardson, S., Bignotti, F., Ferruti, P., and Duncan, R., 1996, Poly(amidoamine)s as pH-sensitive drug carriers: evaluation of biocompatibility and membrane interaction, Proceedings of the 1st International Symposium on Polymer Therapeutics: Form the Laboratory to Clinical Practice, London).
Richardson, S., Ferruti, P., and Duncan, R., 1998, The body distribution of poly(amido-amines) and their DNA complexes, Proceedings of the 3rd International Symposium on Polymer Therapeutics, London, Jan. 7–9.
Rusconi, L., Tanzi, M.C., Ferruti, P., Angiolini, L., Barbucci, R., and Casolaro, M., 1982a, Thermodinamics of protonation and complex formation of multifunctional polymers, Polymer 23:1223.
Rusconi, L., Tanzi, M.C., Garlaschelli, G., Ferruti, P., and Angiolini, L., 1982b, Synthesis and characterization of a poly(amido-amine) with amido and tertiary amino groups regulary alternating along the macromolecular chain, Makromol. Chem., Rapid Commun., 3:909.
Schacht, E., Ferruti, P., and Duncan, R., 1997, Drug delivery agents incorporating mitomycin“, PCT Intern. Pat. Appl N° PCT/IB94/00259, Oct. 1.
Sgouras, D., and Duncan, R., 1990, Methods for the evaluation of biocompatibility of of soluble synthetic polymers which have potential for biomedical use: 1-Use of tetrazolium-based colorimetric assay (MTT) as a preliminary screen for evaluation of in vitro cytotoxicity, Journal of Materials Science: Materials and Medicine, 1:61.
Tanzi, M.C., Barzaghi, B., Anouchinsky, R., Bilenkis, S., Penhasi, A., and Cohn, D., 1992, Grafting reactions and heparin adsorption of poly(amidoamine)-grafted poly(urethane-amide)s, Biomaterials, 13:425.
Tanzi, M.C., Rusconi, L., Barozzi, C, Ferruti, P., Angiolini, L., Nocentini, M., Barone, V., and Barbucci, R., 1984a, Synthesis and characterization of piperazine-derived poly(amido-amine)s with different distribution of amido-and amino-froups along the macromolecular chain, Polymer, 25:863.
Tanzi, M.C., Tieghi, G, Botto, P., Barozzi, C., Cardillo, P., 1984b, Synthesis and characterization of poly(amido-amine)s belonging to two different homologous series, Biomaterials, 5:357.
Tiller, G.E., Mueller, T.J., Dockter, M.E., and Struve, W.G., 1984, Hydrogénation of Triton X-100 eliminates its fluorescence and ultraviolet light absorption while preserving its detergent properties, Anal. Biochem. 141:262.
Vansteenkiste, S., Schacht, E., Ranucci, E., and Ferruti, P., 1992, Synthesis of a new family of poly(amidoamine)s carrying poly(oxyethylene) side chains, Makromol Chem., 193:937.
Vert, M., 1986, Polyvalent polymeric drug carriers, CRC Crit. Rev. Ther. Drug Carrier Syst., 2:291.
Wu, J.Y., and Wu, C.H., 1993, Liver directed gene delivery, Adv. Drug. Del. Rev., 12:159.
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Ferruti, P., Duncan, R., Richardson, S. (1998). Tailor-Made Soluble Polymer Carriers. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 6. NATO ASI Series, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0127-9_19
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DOI: https://doi.org/10.1007/978-1-4899-0127-9_19
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