Skip to main content

Iron Metabolism and Siderophores in Pseudomonas and Related Species

  • Chapter
Pseudomonas

Part of the book series: Biotechnology Handbooks ((BTHA,volume 10))

Abstract

With the exception of mainly lactic acid bacteria (Archibald, 1983; Pandey et al., 1994), iron is required as an oligoelement by all living organisms and particularly by aerobic bacteria, such as Pseudomonas. Because of its redox potentialities, this element is involved in many, if not all, primary biological functions, e. g., electron transport, carbon metabolism, nitrogen fixation, and nucleic acid biosynthesis. Although abundant in nature, iron is, however, not readily available for bacteria because of its profound tendency to hydrolyze and polymerize at physiological pH under aerobiosis. Thus, solubilization of environmental iron by excretion of powerful iron-chelating secondary metabolites, i. e., the siderophores, is the most common way used by microorganisms to sustain their iron requirement.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, G., Dowling, D. N., O’Sullivan, D. J., and O’Gara, F., 1994, Isolation of a gene (pbsC) required for siderophore biosynthesis in fluorescent Pseudomonas sp. strain Ml 14, Mol. Gen. Genet. 243: 515–524.

    CAS  PubMed  Google Scholar 

  • Andriollo, N., Guarini, A., and Cassini, G., 1992, Isolation and characterization of pseudobactin B: A pseudobactin-type siderophore from Pseudomonas species strain PD30, J Agric. Food Chem. 40: 1245–1248.

    CAS  Google Scholar 

  • Ankenbauer, R. G., 1992, Cloning of the outer membrane high-affinity Fe(III)-pyochelin receptor of Pseudomonas aeruginosa, J. Bacteriol. 174: 4401–4409.

    CAS  PubMed  Google Scholar 

  • Ankenbauer, R. G., and Cox, C. D., 1988, Isolation and characterization of Pseudomonas aeruginosa mutants requiring salicylic acid for pyochelin biosynthesis, J. Bacteriol. 170: 5364–5367.

    CAS  PubMed  Google Scholar 

  • Ankenbauer, R. G., and Quan, H. N., 1994, FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa, a phenolate siderophore receptor homologous to hydroxamate siderophore receptors, J. Bacteriol. 176: 307–319.

    CAS  PubMed  Google Scholar 

  • Ankenbauer, R., Sriyosachati, S., and Cox, C. D., 1985, Effects of siderophores on the growth of Pseudomonas aeruginosa in human serum and transferrin, Infect. Immun. 49: 132–140.

    CAS  PubMed  Google Scholar 

  • Ankenbauer, R., Hanne, L. F., and Cox, C. D., 1986, Mapping of mutations in Pseudomonas aeruginosa defective in pyoverdin production, J. Bacteriol. 167: 7–11.

    CAS  PubMed  Google Scholar 

  • Ankenbauer, R. G., Toyokuni, T., Staley, A., Rinehart, K. L., and Cox, C. D., 1988, Synthesis and biological activity of pyochelin, a siderophore of Pseudomonas aeruginosa, J. Bacteriol. 170: 5344–5351.

    CAS  PubMed  Google Scholar 

  • Anwar, H., Brown, M. R., Cozens, R. M., and Lambert, P. A., 1983, Isolation of the outer and cytoplasmic membranes of Pseudomonas cepacia, J. Gen. Microbiol. 129: 499–507.

    CAS  PubMed  Google Scholar 

  • Archibald, F., 1983, Lactobacillus plantarum, an organism not requiring iron, FEMS Microbiol. Lett. 19: 29–32.

    CAS  Google Scholar 

  • Arnow, L. E., 1937, Colorimetrie determination of the components of 3,4-dihydroxy-phenylalanine-tyrosine mixtures, J Biol. Chem. 118: 531–537.

    CAS  Google Scholar 

  • Azegami, K., Nishiyama, K., and Kato, H., 1988, Effects of iron on “Pseudomonas plantarii” growth and tropolone and protein production, Appl. Environ. Microbiol. 54: 844–847.

    CAS  PubMed  Google Scholar 

  • Azelvandre, P., 1993, Les deferriferrioxamines E et D2, sidérophores de Pseudomonas stutzeri, Thèse d’Université, Strasbourg, France.

    Google Scholar 

  • Aznar, R., and Alcaide, E., 1992, Siderophores and related outer membrane proteins produced by pseudomonads isolated from eels and freshwater, FEMS Microbiol. Lett. 98: 269–276.

    CAS  Google Scholar 

  • Bagg, A., and Neilands, J. B., 1987a, Ferric uptake regulation protein acts as a repressor, employing iron(II) as a cofactor to bind the operator of an iron transport operon in Escherichia coli, Biochemistry 26: 5471–5477.

    CAS  PubMed  Google Scholar 

  • Bagg, A., and Neilands, J. B., 1987b, Molecular mechanism of regulation of siderophore-mediated iron assimilation, Microbiol. Rev. 51: 509–518.

    CAS  PubMed  Google Scholar 

  • Barbhaiya, H. B., and Rao, K. K., 1985, Production of pyoverdine, the fluorescent pigment of Pseudomonas aeruginosa PAO1, FEMS Microbiol. Lett. 27: 233–235.

    CAS  Google Scholar 

  • Barker, W. R., Callaghan, C., Hill, L., Nobel, D., Acred, P., Harper, P. B., Sowa, M. A., and Fletton, R. A., 1979, G1549, a new cyclic hydroxamic acid antibiotic, isolated from culture broth of Pseudomonas alcaligenes, J. Antibiotics 32: 1096–1103.

    CAS  Google Scholar 

  • Berk, R. S., 1993, Genetic regulation of the murine corneal and non-corneal response to Pseudomonas aeruginosa, in: Pseudomonas aeruginosa as an Opportunistic Pathogen (M. Campa, M. Bendinelli and H. Friedman, eds.), Plenum Press, New York, pp. 183–206.

    Google Scholar 

  • Berner, I., Konetschny-Rapp, S., Jung, G., and Winkelmann, G., 1988, Characterization of ferrioxamine E as the principal siderophore of Erwinia herbicola (Enterobacter agglomerans), Biol. Metals 1: 51–56.

    CAS  Google Scholar 

  • Bevivino, A., Tabacchioni, S., Chiarini, L., Carusi, M. V., Del Gallo, M., and Visca, P., 1994, Phenotypic comparison between rhizosphere and clinical isolates of Burkholderia cepacia, Microbiology 140: 1069–1077.

    CAS  PubMed  Google Scholar 

  • Bickel, H., Booshardt, R., Gäumann, E., Reusser, P., Vischer, E., Voser, W., Wettstein, A., and Zähner, H., 1960, Stoffwechselprodukte von Actinomyceten. 26. Mitteilung, über die Isolierung und Charakterisierung der Ferrioxamine A-F, neuer Wuchstoffe der Sideramin-Gruppe, Helv. Chim. Acta 53: 2118–2128.

    Google Scholar 

  • Bitter, W., Marrug, J. D., de Weger, L. A., Tommassen, J., and Weisbeek, P. J., 1991, The ferric-pseudobactin receptor PupA of Pseudomonas putida WCS358: Homology to TonB-dependent Escherichia coli receptors and specificity of the protein, Mol. Microbiol 5: 647–655.

    CAS  PubMed  Google Scholar 

  • Bitter, W., Tommassen, J., and Weisbeek, P. J., 1993, Identification and characterization of exbB, exbD, and tonB genes of Pseudomonas putida WCS358: Their involvement in ferricpseudobactin transport, Mol. Microbiol. 7:117–130.

    CAS  PubMed  Google Scholar 

  • Bitter, W., van Leeuwen, I. S., de Boer, J., Zomer, H. W. M., Koster, M. C., Weisbeek, P. J., and Tommassen, J., 1994, Localization of functional domains in the Escherichia coli coprogen receptor FhuE and the Pseudomonas putida ‘ferric-pseudobactin 358 receptor PupA, Mol. Gen. Genet. 245: 694–703.

    CAS  PubMed  Google Scholar 

  • Bjorn, M. J., Sokol, P. A., and Iglewski, B. H., 1979, Influence of iron on yields of extracellular products in Pseudomonas aeruginosa cultures, J. Bacteriol. 138: 193–200.

    CAS  PubMed  Google Scholar 

  • Bodey, G. P., Bolivar, R., Fainstein, V., and Jadeja, L., 1983, Infections caused by Pseudomonas aeruginosa, Rev. Infect. Dis. 5: 279–313.

    CAS  PubMed  Google Scholar 

  • Braun, V., and Hantke, K., 1991, Genetics of bacterial iron transport, in: Handbook of Microbial Chelates (G. Winkelmann, ed.), CRC Press, Boca Raton, Florida, pp. 107–138.

    Google Scholar 

  • Braun, V., Hantke, K., Eick-Helmerich, K., Köster, W., Pressler, U., Sauer, M., Schäffer, S., Schöffler, H., Staudenmaier, H., and Zimmermann, L., 1987, Iron transport systems in Escherichia coli, in: Iron Transport in Microbes, Plants, and Animals (G. Winkelmann, D. van der Helm and J. B. Neilands, eds.), VCH Verlagsgesellschaft, Weinheim, pp. 35–51.

    Google Scholar 

  • Briskot, G., Taraz, K., and Budzikiewicz, H., 1989, Pyoverdin-type siderophores from Pseudomonas aeruginosa. Liebigs Ann. Chem. 1989: 375–384.

    Google Scholar 

  • Britigan, B. E., Hayek, M. B., Doebbeling, B. N., and Fick, R. B., Jr., 1993, Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fibrosis, Infect. Immun. 61: 5049–5055.

    CAS  PubMed  Google Scholar 

  • Brown, M. R. W., Anwar, H., and Lambert, P. A., 1984, Evidence that mucoid Pseudomonas aeruginosa in the cystic fibrosis lung grows under ironrrestricted conditions, FEMS Microbiol. Lett. 21: 113–117.

    CAS  Google Scholar 

  • Budzikiewicz, H., 1993, Secondary metabolites from fluorescent pseudomonads, FEMS Microbiol. Rev. 104: 209–228.

    CAS  Google Scholar 

  • Budzikiewicz, H., 1994, The biosynthesis of pyoverdins, Pure &apm; Appl. Chem. 66: 2207–2210.

    CAS  Google Scholar 

  • Budzikiewicz, H., Schröder, H., and Taraz, K., 1992, Zur Biogenese der Pseudomonos-Siderophore: Der Nachweis analoger Strukturen eines Pyoverdin-Desferriferribactin Paares, Z. Naturforsch. 47c: 26–32.

    Google Scholar 

  • Bukowits, G. J., Mohr, N., and Budzikiewicz, H., 1982, 2-phenylthiazol-derivatives from Pseudomonas cepacia, Z. Naturforsch. 37b:877–880.

    Google Scholar 

  • Bulen, W. A., and LeComte, J. R., 1962, Isolation and properties of a yellow-green fluorescent peptide from Azotobacter medium, Biochem. Biophys. Res. Commun. 9: 523–528.

    CAS  PubMed  Google Scholar 

  • Burkholder, W. H., 1950, Sour skin, a bacterial rot of onion bulbs, Phytopathol. 40: 115–117.

    Google Scholar 

  • Buyer, J. S., and Leong, J., 1986, Iron transport-mediated antagonism between plant growth-promoting and plant-deleterious Pseudomonas strains, J. Biol. Chem. 261: 791–794.

    CAS  PubMed  Google Scholar 

  • Buyer, J. S., Wright, J. S., and Leong, J., 1986, Structure of pseudobactin A214, a side-rophore from a bean-deleterious Pseudomonas, Biochemistry 25: 5492–5499.

    CAS  PubMed  Google Scholar 

  • Buyer, J. S., de Lorenzo, V., and Neilands, J. B., 1991, Production of the siderophore aerobactin by a halophilic pseudomonad, Appl. Environ. Microbiol. 57: 2246–2250.

    CAS  PubMed  Google Scholar 

  • Carlson, C. A., Pierson, L. S., Rosen, J. J., and Ingraham, J. L., 1983, Pseudomonas stutzeri and related species undergo natural transformation, J. Bacteriol. 153: 93–99.

    CAS  PubMed  Google Scholar 

  • Chakraborty, R. N., Patel, H. N., and Desai, S. B., 1990, Isolation and partial characterization of catechol-type siderophore from Pseudomonas stutzeri RC 7, Curr. Microbiol. 20: 283–286.

    CAS  Google Scholar 

  • Champomier-Vergès, M. C., Stintzi, A., and Meyer, J. M., 1996, Acquisition of iron by the non-siderophore producing Pseudomonas fragi, Microbiology 142: 1191–1199.

    PubMed  Google Scholar 

  • Cody, Y. S., and Gross, D. C., 1987, Characterization of pyoverdin Pss, the fluorescent siderophore produced by Pseudomonas syringae pv. syringae. Appl. Environ. Microbiol. 53: 928–934.

    CAS  PubMed  Google Scholar 

  • Colmer, J. A., and Hamood, A. N., 1995, Isolation of a Pseudomonas aeruginosa chromosomal fragment which affects the regulation of siderophore production, Pseudomonas News Letter 20(3): 8.

    Google Scholar 

  • Cornelis, P., Moguilevsky, N., Jacques, J. F., and Masson, P. L., 1987, Study of the side-rophores and receptors in different clinical isolates of Pseudomonas aeruginosa, Antibiot. Chemother. 39: 290–306.

    CAS  PubMed  Google Scholar 

  • Cornelis, P., Hohnadel, D., and Meyer, J. M., 1989, Evidence for different pyoverdine-mediated iron uptake systems among Pseudomonas aeruginosa strains, Infect. Immun. 57: 3491–3497.

    CAS  PubMed  Google Scholar 

  • Cook, R. J., Thomashow, L. S., Weiler, D. M., Fujimoto, D., Mazzola, M., Bangera, G., and Kim, D., 1995, Molecular mechanisms of defense by rhizobacteria against root disease, Proc. Natl. Acad. Sci. USA 92: 4197–4201.

    CAS  PubMed  Google Scholar 

  • Coves, J., and Fontecave, M., 1993, Reduction and mobilization of iron by a NAD(P)H:fla-vin oxidoreductase from Escherichia coli, Eur.J. Biochem. 211: 635–641.

    CAS  PubMed  Google Scholar 

  • Cox, C. D., 1980, Iron uptake with ferripyochelin and ferric citrate by Pseudomonas aeruginosa, J. Bacteriol. 142: 581–587.

    CAS  PubMed  Google Scholar 

  • Cox, C. D., 1982, Effect of pyochelin on the virulence of Pseudomonas aeruginosa, Infect. Immun. 36: 17–23.

    CAS  PubMed  Google Scholar 

  • Cox, C. D., and Adams, P., 1985, Siderophore activity of pyoverdin for Pseudomonas aeruginosa, Infect. Immun. 48: 130–138.

    CAS  PubMed  Google Scholar 

  • Cox, C. D., and Graham, R., 1979, Isolation of an iron-binding compound from Pseudomonas aeruginosa, J. Bacteriol. 137: 357–364.

    CAS  PubMed  Google Scholar 

  • Cox, C. D., Rinehart, K. L., Moore, M. L., and Cook, J. C., 1981, Pyochelin: Novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. USA 78: 4256–4260.

    CAS  PubMed  Google Scholar 

  • Cunliffe, H. E., Merriman, T. R., and Lamont, I., 1995, Cloning and characterization of pvdS, a gene required for pyoverdine synthesis in Pseudomonas aeruginosa: PvdS is probably an alternative sigma factor, J. Bacteriol. 177: 2744–2750.

    CAS  PubMed  Google Scholar 

  • Cuypers, H., and Zumft, W. G., 1992, Regulatory components of the denitrification gene cluster of Pseudomonas stutzeri, in: Pseudomonas: Molecular Biology and Biotechnology (E. Galli, S. Silver, and B. Witholt, eds.), American Society for Microbiology, Washington, D.C., pp. 188–197.

    Google Scholar 

  • Csaky, T. Z., 1948, On the estimation of bound hydroxylamine in biological materials, Acta Chem. Scand. 2: 450–454.

    CAS  Google Scholar 

  • Dean, C. R., and Poole, K., 1993a, Cloning and characterization of the ferric enterobactin receptor gene (pfeA) of Pseudomonas aeruginosa, J. Bacteriol. 175: 317–324.

    CAS  PubMed  Google Scholar 

  • Dean, C. R., and Poole, K., 1993b, Expression of the ferric enterobactin receptor (PfeA) of Pseudomonas aeruginosa: Involvement of a two-component regulatory system, Mol. Microbiol. 8: 1095–1103.

    CAS  PubMed  Google Scholar 

  • Défago, G., and Haas, D., 1990, Pseudomonas as antagonists of soilborne plant pathogens: Modes of action and genetic analysis, in: Soil Biochemistry (J.-M. Bollag and G. Stotzky, eds.), Marcel Dekker, New York and Basel, Vol. 6, pp. 249–291.

    Google Scholar 

  • Démange, P., Bateman, A., Mertz, C., Dell, A., Piémont, Y., and Abdallah, M. A., 1990, Bacterial siderophores: Structures of pyoverdins Pt, siderophores of Pseudomonas tolaasii NCPPB 2192, and pyoverdins Pf, siderophores of Pseudomonas fluorescens CCM 2798. Identification of an unusual amino acid, Biochemistry 29: 11041–11051.

    PubMed  Google Scholar 

  • de Weger, L. A., van Boxtel, R., van der Burg, B., Gruters, R. A., Geels, F. P., Schippers, B., and Lugtenberg, B., 1986, Siderophores and outer membrane proteins of anatagonis-tic, plant-growth-stimulating, root-colonizing Pseudomonas spp., J. Bacteriol. 165: 585–594.

    PubMed  Google Scholar 

  • de Weger, L. A., von Arendonk, J. C. H. M., Recourt, K., van der Hofstad, G. A. J. M., Weisbeek, P. J., and Lugtenberg, B., 1988, Siderophore-mediated iron uptake in the plant-stimulating Pseudomonas putida WCS358 and other rhizosphere microorganisms, J. Bacteriol. 170: 4693–4698.

    PubMed  Google Scholar 

  • de Weger, L. A., van der Bij, A. J., Dekkers, L. C., Simons, M., Wijffelman, A., and Lugtenberg, B. J. J., 1995, Colonization of the rhizosphere of crop plants by plant-beneficial pseudomonads, FEMS Microbiol. Ecol. 17: 221–228.

    Google Scholar 

  • Döhler, K., Huss, V. A. R., and Zumft, W. G., 1987, Transfer of Pseudomonas perfectomarina (Baumann, Bowditch, and Beaman 1983) to Pseudomonas stutzeri (Lehmann and Neumann 1896; Sijderius 1946), Int.J. Syst. Bacteriol. 37: 1–3.

    Google Scholar 

  • Döring, G., 1993, Pseudomonas aeruginosa lung infection in cystic fibrosis patients, in: Pseudomonas aeruginosa as an Opportunistic Pathogen (M. Campa, M. Bendinelli, and H. Friedman, eds.), Plenum Press, New York, pp. 245–273.

    Google Scholar 

  • Döring, G., Pfestorf, M., Botzenhart, K., and Abdallah, M. A., 1988, Impact of proteases on iron uptake of Pseudomonas aeruginosa pyoverdin from transferrin and lactoferrin, Infect. Immun. 56: 291–293.

    PubMed  Google Scholar 

  • Elliot, R. P., 1958, Some properties of pyoverdine, the water-soluble pigment of the Pseudomonas, Appl. Microbiol. 6: 241–246.

    Google Scholar 

  • Fleiszig, S. M. J., Zaidi, T. S., Fletcher, E. L., Preston, M. J., and Pier, G. B., 1994, Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection, Infect. Immun. 62: 3485–3493.

    CAS  PubMed  Google Scholar 

  • Fukasawa, K., and Goto, M., 1973, Biosynthesis of a heterocycle formed by iron-deficient Azotobacter vinelandii strain O, Biochim. Biophys. Acta 320: 545–548.

    CAS  PubMed  Google Scholar 

  • Garibaldi, J. A., 1971, Influence of temperature on the iron metabolism of a fluorescent pseudomonad, J. Bacteriol. 105: 1036–1038.

    CAS  PubMed  Google Scholar 

  • Garibaldi, J. A., 1972, Influence of temperature on the biosynthesis of iron transport compounds by Salmonella typhimurium, J. Bacteriol. 110: 262–265.

    CAS  PubMed  Google Scholar 

  • Geisen, K., Taraz, K., and Budzikiewicz, H., 1992, Neue Siderophore des Pyoverdin-typs aus Pseudomonas fluorescens, Monatsh. Chem. 123: 151–178.

    CAS  Google Scholar 

  • Gensberg, K., Hughes, K., and Smith, A. W., 1992, Siderophore-specific induction of iron uptake in Pseudomonas aeruginosa, J. Gen. Microbiol. 138: 2381–2387.

    CAS  PubMed  Google Scholar 

  • Gensberg, K., Doyle, E. J., Perry, D. J., and Smith, A. W., 1994, Uptake of BRL 41897A, a C(7) α-formamido substituted cephalosporin, via the ferri-pyochelin transport system of Pseudomonas aeruginosa, J. Antimicrob. Chemother. 34: 697–705.

    CAS  PubMed  Google Scholar 

  • Georges, C., and Meyer, J. M., 1995, High-molecular-mass, iron-repressed cytoplasmic proteins in fluorescent Pseudomonas: Potential peptide-synthetases for pyoverdine biosynthesis, FEMS Microbiol. Lett. 132: 9–17.

    CAS  PubMed  Google Scholar 

  • Gessner, A. R., and Mortensen, J. E., 1990, Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis, J. Med. Microbiol. 33: 115–120.

    CAS  PubMed  Google Scholar 

  • Gillam, A. H., Lewis, A. G., and Andersen, R. J., 1981, Quantitative determination of hydroxamic acids, Anal. Chem. 53: 841–844.

    CAS  Google Scholar 

  • Gillis, M., Trân Van, V., Fernandez, M. P., Goor, M., Hebbar, P., Willems, A., Segers, P., Kersters, K., Heulin, T., and Bardin, R., 1995, Polyphasic taxonomy in Burkholderia leading to an amended description of the genus and proposition of Burkholderia vietna-miensis sp. nov. for N2-fixing isolates from rice in Vietnam. Int. J. Syst. Bacteriol. 45: 274–289.

    CAS  Google Scholar 

  • Gipp, S., Hahn, J., Taraz, K., and Budzikiewicz, H., 1991, Zwei Pyoverdine aus Pseudomonas aeruginosa R, Z. Naturforsch. 46c: 534–541.

    Google Scholar 

  • Glick, B. R., 1995, The enhancement of plant growth by free-living bacteria, Can. J. Microbiol. 41: 109–117.

    CAS  Google Scholar 

  • Goetz, A., Yu, V. L., Hanchett, J. E., and Rihs, J. D., 1983, Pseudomonas stutzen bacteremia associated with hemodialysis, Arch. Intern. Med. 143: 1909–1912.

    CAS  PubMed  Google Scholar 

  • Govan, J. R., Brown, P. H., Maddison, J., Doherty, C. J., Nelson, J. W., Dodd, M., Greening, A. P., and Webb, A. K., 1993, Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis, Lancet 342: 15–19.

    CAS  PubMed  Google Scholar 

  • Gwose, I., and Taraz, K., 1992, Pyoverdine aus Pseudomonas putida, Z. Naturforsch. 47c: 487–502.

    Google Scholar 

  • Haas, B., Kraut, J., Marks, J., Zanker, S. C., and Castignetti, D., 1991, Siderophore presence in sputa of cystic fibrosis patients, Infect. Immun. 59: 3997–4000.

    CAS  PubMed  Google Scholar 

  • Hallé, F., and Meyer, J. M., 1992a, Ferrisiderophore reductases of Pseudomonas. Purification, properties and location of the Pseudomonas aeruginosa ferripyoverdine reductase, Eur.J. Biochem. 209: 613–620.

    PubMed  Google Scholar 

  • Hallé, F., and Meyer, J. M., 1992b, Iron release from ferrisiderophores. A multi-step mechanism involving a NADH/FMH oxidoreductase and a chemical reduction by FMNH2, Eur.J. Biochem. 209: 621–627.

    PubMed  Google Scholar 

  • Hancock, D. K., and Reeder, D. J., 1993, Analysis and configuration assignments of the amino acids in a pyoverdine-type siderophore by reversed-phase high-performance liquid chromatography, J. Chromatogr. 646: 335–343.3

    CAS  Google Scholar 

  • Harding, R. A., and Royt, P., 1990, Acquisition of iron from citrate by Pseudomonas aeruginosa, J. Gen. Microbiol. 136: 1859–1867.

    CAS  PubMed  Google Scholar 

  • Hebbar, K. P., Davey, A. G., Merrin, J., and Dart, P. J., 1992, Pseudomonas cepacia, a potential suppressor of maize soil-borne diseases-seed inoculation and maize root colonization, Soil. Biol. Biochem. 24: 999–1007.

    Google Scholar 

  • Heinrichs, D. E., and Poole, K., 1993, Cloning and sequence analysis of a gene (pchR) encoding an Ara C family activator of pyochelin and ferripyochelin receptor synthesis in Pseudomonas aeruginosa, J. Bacteriol. 175: 5882–5889.

    CAS  PubMed  Google Scholar 

  • Heinrichs, D. E., and Poole, K., 1996, PchR, a regulator of ferripyochelin receptor gene (fptA) expression in Pseudomonas aeruginosa, functions both as an activator and as a repressor, J. Bacteriol. 178: 2586–2592.

    CAS  PubMed  Google Scholar 

  • Heinrichs, D. E., Young, L., and Poole, K., 1991, Pyochelin-mediated iron transport in Pseudomonas aeruginosa: Involvement of a high-molecular-mass outer membrane protein, Infect. Immun. 59: 3680–3684.

    CAS  PubMed  Google Scholar 

  • Höfte, M., Buysens, S., Koedam, N., and Cornelis, P., 1993, Zinc affects siderophore-mediated high affinity iron uptake systems in the rhizosphere Pseudomonas aeruginosa 7NSK2, BioMetah 6: 85–91.

    Google Scholar 

  • Höfte, M., Dong, Q., Kourambas, S., Krishnapillai, V., Sherratt, D., and Mergeay, M., 1994, The sss gene product, which affects pyoverdin production in Pseudomonas aeruginosa 7NSK2 is a site-specific recombinase, Mol. Microbiol. 14: 1011–1020.

    PubMed  Google Scholar 

  • Hohlneicher, U., Hartmann, R., Taraz, K., and Budzikiewicz, H., 1992, The structure of ferribactin from Pseudomonas fluorescens ATCC 13525, Z. Naturforsch. 47b: 1633–1638.

    Google Scholar 

  • Hohlneicher, U., Hartmann, R., Taraz, K., and Budzikiewicz, H., 1995, Pyoverdin, ferribactin, azotobactin-a new triade of siderophores from Pseudomonas chlororaphis ATCC 9446 and its relation to Pseudomonas fluorescens ATCC 13525, Z. Naturforsch. 50c: 337–344.

    Google Scholar 

  • Hohnadel, D., and Meyer, J. M., 1988, Specificity of pyoverdine-mediated iron uptake among fluorescent Pseudomonas strains, J. Bacteriol. 170: 4865–4873.

    CAS  PubMed  Google Scholar 

  • Hohnadel, D., Haas, D., and Meyer, J. M., 1986, Mapping of mutations affecting pyover-dine production in Pseudomonas aeruginosa, FEMS Microbiol. Lett. 36: 195–199.

    CAS  Google Scholar 

  • Holder, I. A., 1993, Pseudomonas aeruginosa burn infections: Pathogenesis and treatment, in: Pseudomonas aeruginosa as an Opportunistic Pathogen (M. Campa, M. Bendinelli, and H. Friedman, eds.), Plenum Press, New York, pp. 275–295.

    Google Scholar 

  • Holloway, B. W., Römling, U., and Tümmler, B., 1994, Genomic mapping of Pseudomonas aeruginosa PAO, Microbiology 140: 2907–2929.

    CAS  PubMed  Google Scholar 

  • Holmes, B., 1986a, Identification and distribution of Pseudomonas stutzen in clinical material, J. Appl. Bacteriol. 60: 401–411.

    CAS  PubMed  Google Scholar 

  • Holmes, B., 1986b, The identification of Pseudomonas cepacia and its occurrence in clinical material, J. Appl. Bacteriol. 61: 299–314.

    CAS  PubMed  Google Scholar 

  • Itoh, J., Miyadoh, S., Takahasi, S., Amano, S., Ezaki, N., and Yamada, Y., 1979, Studies on antibiotics BN-227 and BN227-F, new antibiotics. I. Taxonomy, isolation, and characterization, J. Antibiotics 32: 1089–1095.

    CAS  Google Scholar 

  • Jacques, P., Gwose, I., Seinsche, D., Taraz, K., Budzikiewicz, H., Schröder, H., Ongena, M., Thonart, P., 1993, Isopyoverdin Pp BTP1, a biogenetically interesting novel side-rophore from Pseudomonas putida, Nat. Prod. Lett. 3: 213–218.

    CAS  Google Scholar 

  • Jacques, P., Ongena, M., Gwose, I., Seinsche, D., Schröder, H., Delfosse, P., Thonart, P., Taraz, K., and Budzikiewicz, H., 1995, Structure and characterization of isopyoverdin from Pseudomonas putida BTP1 and its relation to the biogenetic pathway leading to pyoverdins, Z. Naturforsch. 50c: 622–629.

    Google Scholar 

  • Jayaswal, R. K., Fernandez, M., Upadhyay, R. S., Visintin, L., Kurz, M., Webb, J., and Rinehart, K., 1993, Antagonism of Pseudomonas cepacia against phytopathogenic fungi, Curr. Microbiol. 26: 17–22.

    CAS  PubMed  Google Scholar 

  • Jurkevitch, E., Hadar, Y., Chen, Y., Libman, J., and Shanzer, A., 1992, Iron uptake and molecular recognition in Pseudomonas putida: Receptor mapping with ferrichrome and its biomimetic analogs, J. Bacteriol. 174: 78–83.

    CAS  PubMed  Google Scholar 

  • Kachadourian, R., Dellagi, A., Laurent, J., Bricart, L., Kunesch, G., and Expert, D., 1996, Desferrioxamine-dependent iron transport in Erwinia amylovora CFBP1430: Cloning of the gene encoding the ferrioxamine receptor FoxR, BioMetals 9: 143–150.

    CAS  PubMed  Google Scholar 

  • King, E. O., Ward, M. K., and Raney, D. F., 1954, Two simple media for the demonstration of pyocyanin and fluorescein, J. Lab. Clin. Med. 44: 301–307.

    CAS  PubMed  Google Scholar 

  • Kisaalita, W S., Slininger, P. J., and Bothast, R. J., 1993, Defined media for optimal pyoverdine production by Pseudomonas fluorescens 2-79, Appl. Microbiol. Biotechnol. 39: 750–755.

    CAS  Google Scholar 

  • Kleinkauf, H., and von Döhren, H., 1987, Biosynthesis of peptide antibiotics, Annu. Rev. Microbiol. 41: 259–289.

    CAS  PubMed  Google Scholar 

  • Kleinkauf, H., and von Döhren, H., 1990, Nonribosomal biosynthesis of peptide antibiotics, Eur.J. Biochem. 192: 1–15.

    CAS  PubMed  Google Scholar 

  • Kloepper, J. W., Leong, J., Teintze, M., and Schroth, M. N., 1980a, Enhanced plant growth by siderophores produced by plant growth promoting rhizobacteria, Nature 286: 885–886.

    CAS  Google Scholar 

  • Kloepper, J. W., Leong, J., Teintze, M., and Schroth, M. N., 1980b, Pseudomonas siderophores: A mechanisms explaining disease suppressive soils, Curr. Microbiol. 4: 317–320.

    CAS  Google Scholar 

  • Koedam, N., Wittouck, E., Gaballa, A., Gillis, A., Höfte, M., and P. Cornelis, 1994, Detection and differentiation of microbial siderophores by isoelectric focusing and chrome azurol S overlay, BioMetals 7: 287–291.

    CAS  PubMed  Google Scholar 

  • Kolasa, T., and Miller, M. J., 1990, Synthesis of the chromophore of pseudobactin, a fluorescent siderophore from Pseudomonas, J. Org. Chem. 55: 4246–4255.

    CAS  Google Scholar 

  • Kontoghiorghes, G. J., 1987, Structure/iron binding activity of l-hydroxypyrid-2-one chelators intended for clinical use, Inorg. Chim. Acta 135: 145–150.

    CAS  Google Scholar 

  • Korth, H., Brüsewitz, G., and Pulverer, G., 1982, Isolation of an antibacterial active tro-polone from a Pseudomonas cepacia strain, Zbl. Bakt. Hyg. I, 252: 83–86.

    CAS  Google Scholar 

  • Koster, M., van de Vossenberg, J., Leong, J., and Weisbeek, P. J., 1993, Identification and characterization of the pupB gene encoding an inducible ferric-pseudobactin receptor of Pseudomonas putida WCS358, Mol. Microbiol. 8: 591–601.

    CAS  PubMed  Google Scholar 

  • Koster, M., van Klompenburg, W., Bitter, W., Leong, J., and Weisbeek, P., 1994, Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope, EMBOJ. 13: 2805–2813.

    CAS  Google Scholar 

  • Krotzky, A., and Werner, D., 1987, Nitrogen fixation in Pseudomonas stutzen, Arch. Microbiol. 147: 48–57.

    CAS  Google Scholar 

  • Lacy, D. E., Spencer, D. A., Weiler, P. H., and Darbyshire, P., 1993, Chronic granulomatous disease presenting in childhood with Pseudomonas cepacia septicaemia, J. Infect. 27: 301–304.

    CAS  PubMed  Google Scholar 

  • Lamont, I. A., 1994, Pseudomonas aeruginosa OT11 pyoverdine synthetase D (pvdD), ferripyoverdine receptor (fpvA), and pyoverdine synthetase E (pvdE) genes, complete cds. GenBank database release 82.0, accession number U07359.

    Google Scholar 

  • Lamont, I. A., 1995, personal communication.

    Google Scholar 

  • Leong, J., 1986, Siderophores: Their biochemistry and possible role in the biocontrol of plant pathogens. Annu. Rev. Phytopathol. 24: 187–209.

    CAS  Google Scholar 

  • Leoni, L., Ciervo, A., Orsi, N., and Visca, P., 1996, Iron-regulated transcription of the pvdA gene in Pseudomonas aeruginosa: Effect of Fur and PvdS on promoter activity, J. Bacteriol. 178: 2299–2313.

    CAS  PubMed  Google Scholar 

  • Lim, H. S., Kim, Y. S., and Kim, S. D., 1991, Pseudomonas stutzen YPL-1 genetic transformation and antifungal mechanism against Fusarium solani, an agent of plant root rot, Appl. Environ. Microbiol. 57: 510–516.

    CAS  PubMed  Google Scholar 

  • Lindberg, G. D., Larkin, J. M., and Whaley, H. A., 1980, Production of tropolone by a Pseudomonas, J. Nat. Prod. 43: 592–594.

    CAS  Google Scholar 

  • Linget, C., Azadi, P., MacLeod, J. K., Dell, A., and Abdallah, M., 1992, Bacterial siderophores: The structure of the pyoverdins of Pseudomonas fluorescens ATCC 13525, Tetrahedron Lett. 33: 1737–1740.

    CAS  Google Scholar 

  • Liu, P. V., and Shokrani, F., 1978, Biological activities of pyochelins: Iron chelating agents of Pseudomonas aeruginosa, Infect. Immun. 22: 878–890.

    CAS  PubMed  Google Scholar 

  • Longerich, I., Taraz, K., Budzikiewicz, H., Tsai, L., and Meyer, J.-M., (1993), Pseudover-din, a compound related to the pyoverdine chromophore from a Pseudomonas aeruginosa strain incapable to produce pyoverdins. Z. Naturforsch. 48c: 425–429.

    Google Scholar 

  • Loper, J. E., Orser, C. S., Panopoulos, N. J., and Schroth, M. N., 1984, Genetic analysis of fluorescent pigment production in Pseudomonas syringae pv. syringae, J. Gen. Micro-biol. 130: 1507-1515.

    Google Scholar 

  • Magazin, M. D., Moores, J. C., and Leong, J., 1986, Cloning of the gene coding for the outer membrane receptor protein for ferric pseudobactin, a siderophore from a plant growth-promoting Pseudomonas strain, J. Biol. Chem. 261:795–799.

    CAS  PubMed  Google Scholar 

  • Maksimova, N. P., Blazhevich, O. V., and Fomichev, Y. K., 1992, Role of phenylalanine in the biosynthesis of the fluorescent pigment of Pseudomonas putida, 61: 818–823.

    CAS  Google Scholar 

  • Maksimova, N. P., Blazhevich, O. V., and Fomichev, Y. K., 1993, The role of pyrimidines in the biosynthesis of the fluorescent pigment pyoverdin Pm in Pseudomonas putida M bacteria, Molekularn. Gen. Microbiol. Virusol. 5: 22–26.

    Google Scholar 

  • Marugg, J. D., van Spanje, M., Hoekstra, W. P. M., Schippers, B., and Weisbeek, P. J., 1985, Isolation and analysis of genes involved in siderophore biosynthesis in plant-growth-stimulating Pseudomonas putida WCS358, J. Bacteriol. 164: 563–570.

    CAS  PubMed  Google Scholar 

  • Marugg, J. D., Nielander, H. B., Horrevoets, A. J. G., van Megen, I., van Genderen, I., and Weisbeek, P. J., 1988, Genetic organization and transcriptional analysis of a major gene cluster involved in siderophore biosynthesis in Pseudomonas putida WCS358, J. Bacteriol. 170: 1812–1819.

    CAS  PubMed  Google Scholar 

  • Marugg, J. D., de Weger, L. A., Nielander, H. B., Oorthuizen, M., Recourt, K., Lugten-berg, B., van der Hofstad, G. A. J. M., and Weisbeek, P. J., 1989, Cloning and characterization of a gene encoding an outer membrane protein required for siderophore-mediated uptake of Fe3+ in Pseudomonas putida WCS358, J. Bacteriol. 171: 2819–2826.

    CAS  PubMed  Google Scholar 

  • Maurer, B., Müller, A., Keller-Schierlein, W., and Zähner, H., 1968, Ferribactin, ein siderochrom aus Pseudomonas fluorescens Migula, Arch. Mikrobiol. 60: 326–339.

    CAS  PubMed  Google Scholar 

  • Menhart, N., and Viswanatha, T., 1990, Precursor activation in a pyoverdine biosynthesis, Biochem. Biophys. Acta 1038: 47–51.

    CAS  PubMed  Google Scholar 

  • Menhart, N., Thariath, A., and Viswanatha, T., 1991, Characterization of the pyoverdines of Azotobacter vinelandii ATCC12837 with regard to heterogeneity, Biol. Metals 4: 223–232.

    CAS  Google Scholar 

  • Merriman, T. R., Merriman, M. E., and Lamont, I. L., 1995, Nucleotide sequence of pvdD, a pyoverdine biosynthetic gene from Pseudomonas aeruginosa: PvdD has similarity to peptide synthetases, J. Bacteriol. 177: 252–258.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., 1992, Exogenous siderophore-mediated iron uptake in Pseudomonas aeruginosa: Possible involvement of porin OprF in iron translocation, J. Gen. Microbiol. 138: 951–958.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., and Abdallah, M. A., 1978, The fluorescent pigment of Pseudomonas fluorescens: Biosynthesis, purification, and physicochemical properties. J. Gen. Microbiol. 107: 319–328.

    CAS  Google Scholar 

  • Meyer, J. M., and Abdallah, M. A., 1980, The siderochromes of non-fluorescent pseu-domonads: Production of nocardamine by Pseudomonas stutzen, J. Gen. Microbiol. 118: 125–129.

    CAS  Google Scholar 

  • Meyer, J. M., and Hohnadel, D., 1992, use of nitrilotriacetic acid (NTA) by Pseudomonas species through iron metabolism, Appl. Microbiol. Biotechnol. 37: 114–118.

    CAS  Google Scholar 

  • Meyer, J. M., and Hornsperger, J.-M., 1978, Role of pyoverdinePf, the iron binding fluorescent pigment of Pseudomonas fluorescens in iron transport, J. Gen. Microbiol. 107: 329–331.

    CAS  Google Scholar 

  • Meyer, J. M., Mock, M., and Abdallah, M. A., 1979, Effect of iron on the protein composition of the outer membrane of fluorescent pseudomonads, FEMS Microbiol. Lett. 5: 395–398.

    CAS  Google Scholar 

  • Meyer, J. M., Hallé, F., Hohnadel, D., Lemanceau, P., and Ratefiarivelo, H., 1987, Siderophores of Pseudomonas-biological properties, in: Iron Transport in Microbes, Plants and Animals (G. Winkelmann, D. van der Helm, and J. B. Neilands, eds.), VCH Verlagsgesellschaft, Weinheim, pp. 188–205.

    Google Scholar 

  • Meyer, J. M., Hallé, F., and Hohnadel, D., 1989, Cepabactin from Pseudomonas cepacia, a new type of siderophores. J. Gen. Microbiol. 135: 1479–1487.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., Hohnadel, D., Kahn, A., and Cornelis, P., 1990, Pyoverdine-facilitated iron uptake in Pseudomonas aeruginosa: Immunological characterization of the ferripyoverdine receptor. Mol. Microbiol. 4: 1401–1405.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., Azelvandre, P., and Georges, C., 1992, Iron metabolism in Pseudomonas: Salicylic acid, a siderophore of Pseudomonas fluorescens CHAO. Biofactors 4: 23–27.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., Tappe, R., Taraz, K., Budzikiewicz, H., de Vos, D., and Cornelis, P., 1993, The three pyoverdine species of Pseudomonas aeruginosa strains, Abstract PI3, Conference on Iron and Microbial Iron Chelates, Brugge, Belgium, November 5-6, 1993.

    Google Scholar 

  • Meyer, J. M., Trän Van, V., Stintzi, A., Berge, O., and Winkelmann, G., 1995, Ornibactin production and transport properties in strains of Burkholderia vietnamiensis and Burkholderia cepacia (formerly Pseudomonas cepacia). BioMetals 8: 309–317.

    CAS  PubMed  Google Scholar 

  • Meyer, J. M., Neely, A., Stintzi, A., Georges, C., and Holder, I. A., 1996, Pyoverdine is essential for virulence of Pseudomonas aeruginosa, Infect. Immun. 64: 518–523.

    CAS  PubMed  Google Scholar 

  • Michels, J., Benoni, H., Briskot, G., Lex, J., Schmickler, H., Taraz, K., Budzikiewicz, H., Korth, H., and Pulverer, G., 1991, Isolation and spectroscopic characterization of the pyoverdin chromophore and of its 5-hydroxy analogue. Z. Naturforsch. 46c: 993–1000.

    Google Scholar 

  • Mielczarek, E. V., Andrews, S. C., and Bauminger, R., 1992, Mössbauer spectroscopy and electron paramagnetic resonance studies of iron metabolites in Pseudomonas aeruginosa: Fe2+ and Fe3+ ferritin in 57ferripyoverdine incubated cells and 57ferric citrate fed cells, BioL Metals 5: 87–93.

    CAS  Google Scholar 

  • Misaghi, I. J., Olsen, M. W., Cotty, P. J., and Donndelinger, C. R., 1988, Fluorescent siderophore-mediated iron deprivation-a contingent biological mechanism, Soil Biol. Biochem. 20: 573–574.

    CAS  Google Scholar 

  • Miyazaki, H., Kato, H., Nakazawa, T., and Tsuda, M., 1995, A positive regulatory gene, pvdS, for expression of pyoverdin biosynthetic genes in Pseudomonas aeruginosa PAO, Mol. Gen. Genet. 248: 17–24.

    CAS  PubMed  Google Scholar 

  • Mohn, G., Taraz, K., and Budzikiewicz, H., 1990, New pyoverdin-type siderophores from Pseudomonas fluorescens, Z. Naturforsch. 45b: 1437–1450.

    Google Scholar 

  • Moore, G. R., Mann, S., and Bannister, J. V., 1986, Isolation and properties of the complex nonheam-iron-containing cytochrome B-557 (bacterioferritin) from Pseudomonas aeruginosa, J. Inorg. Biochem. 28: 329–336.

    CAS  PubMed  Google Scholar 

  • Moores, J. C., Magazin, M., Ditta, G. S., and Leong, J., 1984, Cloning of genes involved in the biosynthesis of pseudobactin, a high-affinity iron transport agent of a plant growth-promoting Pseudomonas strain, J. Bacteriol. 157: 53–58.

    CAS  PubMed  Google Scholar 

  • Morgan, M. K., and Chatterjee, A. K., 1988, Genetic organization and regulation of proteins associated with production of syringotoxin by Pseudomonas syringae pv. syringae, J. Bacteriol. 170: 5689–5697.

    CAS  PubMed  Google Scholar 

  • Morris, J., O’Sullivan, D. J., Koster, M., Leong, J., Weisbeek, P. J., and O’Gara, F., 1992, Characterization of fluorescent siderophore-mediated iron uptake in Pseudomonas sp. strain Ml 14: Evidence for the existence of an additional ferric siderophore receptor, Appl. Environ. Microbiol. 58: 630–635.

    CAS  PubMed  Google Scholar 

  • Münziger, M., 1995, Siderophore aus Pseudomonas solanacearum ATCC 11696, Diplomarbeit, Köln Universität, Köln, Germany.

    Google Scholar 

  • Neilands, J. B., 1957, Some aspects of microbial iron metabolism, Bacteriol. Rev. 21: 101–105.

    CAS  PubMed  Google Scholar 

  • Neilands, J. B., 1981, Microbial iron compounds, Annu. Rev. Biochem. 50: 715–731.

    CAS  PubMed  Google Scholar 

  • Neilands, J. B., 1982, Microbial envelope proteins related to iron, Annu. Rev. Microbiol. 36: 285–309.

    CAS  PubMed  Google Scholar 

  • Neilands, J. B., and Nakamura, K., 1991, Detection, determination, isolation, characterization, and regulation of microbial iron chelates, in: Handbook of Microbial Iron Chelates (G. Winkelmann, ed.), CRC Press, Boca Raton, Florida, USA, pp. 1–14.

    Google Scholar 

  • Neilands, J. B., Konopka, K., Schwyn, B., Coy, M., Francis, R. T., Paw, B. H., and Bagg, A., 1987, Comparative biochemistry of microbial iron assimilation, in: Iron Transport in Microbes, Plants, and Animals (G. Winkelmann, D. van der Helm, and J. B. Neilands, eds.), VCH Verlaggesellschaft, Weinheim, Germany, pp. 3–33.

    Google Scholar 

  • Newkirk, J. D., and Hulcher, F. H., 1969, Isolation and properties of a fluorescent pigment from Pseudomonas mildenbergii, Arch. Biochem. Biophys. 134: 395–400.

    CAS  PubMed  Google Scholar 

  • Nowak-Thomson, B., and Gould, S. J., 1994a, A simple assay for fluorescent siderophores produced by Pseudomonas species and an efficient isolation of pseudobactin, BioMetals 7: 20–24.

    Google Scholar 

  • Nowak-Thomson, B., and Gould, S. J., 1994b, Biosynthesis of the pseudobactin chromo-phore from tyrosine, Tetrahedron 50: 9865–9872.

    Google Scholar 

  • O’Hoy, K., and Krishnapillai, V., 1987, Recalibration of the Pseudomonas aeruginosa PAO strain chromosome map in time units using high-frequency-of-recombination donors, Genetics 115: 611–618.

    PubMed  Google Scholar 

  • Okonya, J. F., Kolsa, T., and Miller, M. J., 1995, Synthesis of the peptide fragment of pseudobactin, J. Org. Chem. 60: 1932–1935.

    CAS  Google Scholar 

  • O’Sullivan, D. J., and O’Gara, F., 1990, Iron regulation of ferric iron uptake in a fluorescent pseudomonad: Cloning of a regulatory gene, Mol. Plant-Microbe Interact. 3: 86–93.

    Google Scholar 

  • O’Sullivan, D. J., and O’Gara, F., 1991, Regulation of iron assimilation: Nucleotide sequence analysis of an iron-regulated promoter from a fluorescent pseudomonad, Mol. Gen. Genet. 228: 1–8.

    PubMed  Google Scholar 

  • O’Sullivan, D. J., and O’Gara, F., 1992, Traits of fluorescent Pseudomonas spp. involved in suppression of plant root pathogens. Microbiol. Rev. 56: 662–676.

    PubMed  Google Scholar 

  • O’Sullivan, D. J., Morris, J., and O’Gara, F., 1990, Identification of an additional ferric-siderophore uptake gene clustered with receptor, biosynthesis, and fur-like regulatory genes in fluorescent Pseudomonas sp. strain Ml 14, Appi. Environ. Microbiol. 56: 2056–2064.

    Google Scholar 

  • Palleroni, N. J., 1984, Pseudomonas, in: Bergey’s Manual of Systematic Bateriology, Volume 1 (N. R. Krieg, ed.), Williams and Wilkins, Baltimore, pp. 141–199.

    Google Scholar 

  • Palleroni, N. J., Doudoroff, M., Stanier, R. Y., Solanes, R. E., and Mandel, M., 1970, Taxonomy of the aerobic pseudomonads: The properties of the Pseudomonas stutzeri group, J. Gen. Microbiol. 60: 215–231.

    CAS  PubMed  Google Scholar 

  • Pandey, A., Bringel, F., and Meyer, J. M., 1994, Iron requirement and search for siderophores in lactic acid bacteria, Appl. Microbiol. Biotechnol. 40: 735–739.

    CAS  Google Scholar 

  • Parke, J. L., Rand, R. E., Joy, A. E., and King, E. B., 1991, Biological control of Pythium damping-off and Aphanomyces root rot of peas by application of Pseudomonas cepacia or P. fluorescens to seed, Plant Dis. 75: 987–992.

    Google Scholar 

  • Pennington, J. E., Reynolds, H. Y., and Carbone, P. P., 1973, Pseudomonas pneumonia: A retrospective study of 36 cases, Am J. Med. 55: 155–160.

    CAS  PubMed  Google Scholar 

  • Persmark, M., Frejd, T., and Mattiasson, B., 1990, Purification, characterization, and structure of pseudobactin 589A, a siderophore from a plant growth promoting Pseudomonas, Biochemistry 29: 7348–7356.

    CAS  PubMed  Google Scholar 

  • Poole, K., Young, L., and Neshat, S., 1990, Enterobactin-mediated iron transport in Pseudomonas aeruginosa, J. Bacteriol. 172: 6991–6996.

    CAS  PubMed  Google Scholar 

  • Poole, K., Neshat, S., and Heinrichs, D., 1991, Pyoverdine-mediated iron transport in Pseudomonas aeruginosa: Involvement of a high-molecular-mass outer membrane protein, FEMS Microbiol. Lett. 78: 1–6.

    CAS  Google Scholar 

  • Poole, K., Heinrichs, D. E., and Neshat, S., 1993a, Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: Regulation by iron and possible involvement in the secretion of the siderophore pyoverdine, Mol. Microbiol. 10: 529–544.

    CAS  PubMed  Google Scholar 

  • Poole, K., Krebes, K., McNally, C., and Neshat, S., 1993b, Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon, J. Bacteriol. 175: 7363–7372.

    CAS  PubMed  Google Scholar 

  • Poole, K., Neshat, S., Krebes, K., and Heinrichs, D. E., 1993c, Cloning and nucleotide sequence analysis of the ferripyoverdine receptor gene fpvA of Pseudomonas aeruginosa, J. Bacteriol. 175: 4597–4604.

    CAS  PubMed  Google Scholar 

  • Poppe, K., Taraz, K., and Budzikiewicz, H., 1987, Pyoverdine-type siderophores from Pseudomonas fluorescens, Tetrahedron 43: 2261–2272.

    CAS  Google Scholar 

  • Prince, R. W., Storey, D. G., Vasil, A. I., and Vasil, M. L., 1991, Regulation of toxA and regA by the Escherichia coli fur gene and identification of a Fur homologue in Pseudomonas aeruginosa PA 103 and PAO1, Mol. Microbiol. 5: 2823–2831.

    CAS  PubMed  Google Scholar 

  • Prince, R. W., Cox, C. D., and Vasil, M. L., 1993, Coordinate regulation of siderophore and exotoxin A production: Molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J. Bacteriol. 175: 2589–2598.

    CAS  PubMed  Google Scholar 

  • Raaijmakers, J. M., Bitter, W., Punte, H. L. M., Bakker, P. A. H. M., Weisbeek, P. J., and Schippers, B., 1994, Siderophore receptor PupA as a marker to monitor wild-type Pseudomonas putida WCS358 in natural environments, Appl. Environ. Microbiol. 60: 1184–1190.

    CAS  PubMed  Google Scholar 

  • Raaijmakers, J. M., van der Sluis, I., Koster, M., Bakker, P. A. H. M., Weisbeek, P. J., and Schippers, B., 1995, Utilization of heterologous siderophores and rhizosphere competence of fluorescent Pseudomonas spp., Can. J. Microbiol. 41: 126–135.

    CAS  Google Scholar 

  • Reissbrodt, R., Rabsch, W., Chapeaurouge, A., Jung, G., and Winkelmann, G., 1990, Isolation and identification of ferrioxamine G and E in Hafnia alvei, Biol. Metals 3: 54–60.

    CAS  Google Scholar 

  • Rombel, L. T., and Lamont, I., 1992, DNA homology between siderophore genes from fluorescent pseudomonads, J. Gen. Microbiol. 138: 181–187.

    CAS  PubMed  Google Scholar 

  • Royt, P., 1988, Isolation of a membrane-associated iron chelator from Pseudomonas aeruginosa, Biochim. Biophys. Acta 939: 493–502.

    CAS  PubMed  Google Scholar 

  • Schröder, H., Adam, J., Taraz, K., and Budzikiewicz, H., 1995, Dihydropyoverdin sulfonic acids-Intermediates in the biogenesis?, Z. Naturforsch. 50c: 616–621.

    Google Scholar 

  • Schroeter, S., 1870, Über durch Bakterien gebildete Pigmente, Cohn’s Beitr. Biol. Pflanzen 1: 109–126.

    Google Scholar 

  • Schwyn, B., and Neilands, J. B., 1987, Universal chemical assay for the detection and determination of siderophores, Anal. Biochem. 160: 47–56.

    CAS  PubMed  Google Scholar 

  • Screen, J., Moya, E., Blagbrough, I. S., and Smith, A. W., 1995, Iron uptake in Pseudomonas aeruginosa mediated by N-(2,3-dihydroxybenzoyl)-L-serine and 2,3-dihydroxybenzoic acid, FEMS Microbiol. Lett. 127: 145–149.

    CAS  PubMed  Google Scholar 

  • Seinsche, D., Taraz, K., and Budzikiewicz, H., 1993, Neue pyoverdin-siderophore aus Pseudomonas putida C, J. Prakt. Chem. 335: 157–168.

    CAS  Google Scholar 

  • Serino, L., Reimmann, C., Baur, H., Beyeler, M., Visca, P., and Haas, D., 1995, Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa, Mol. Gen. Genet. 249: 217–228.

    CAS  PubMed  Google Scholar 

  • Sexton, R., Gill, P. R., Callanan, M. J., O’Sullivan, D. J., Dowling, D. N., and O’Gara, F., 1995, Iron-responsive gene expression in Pseudomonas fluorescens Ml 14: Cloning and characterization of a transcription-activating factor, PbrA, Mol. Microbiol. 15: 297–306.

    CAS  PubMed  Google Scholar 

  • Shand, G. H., Anwar, H., Kadurugamuwa, J., Brown, M. R., Silverman, S. H., and Melling, J., 1985, In vivo evidence that bacteria in urinary tract infection grow under iron-restricted conditions, Infect. Immun. 48: 35–39.

    CAS  PubMed  Google Scholar 

  • Smith, A. W., Hirst, P. H., Hughes, K., Gensberg, K., and Govan, J. R. W., 1992, The pyocin Sa receptor of Pseudomonas aeruginosa is associated with ferripyoverdin uptake, J. Bacteriol. 174: 4847–4849.

    CAS  PubMed  Google Scholar 

  • Smith, A. W., Poyner, D. R., Hughes, H. K., and Lambert, P. A., 1994, Siderophore activity of myo-inositol hexakisphosphate in Pseudomonas aeruginosa, J. Bacteriol. 176: 3455–3459.

    CAS  PubMed  Google Scholar 

  • Sokol, P. A., 1986, Production and utilization of pyochelin by clinical isolates of Pseudomonas cepacia, J. Clin. Microbiol. 23: 560–562.

    CAS  PubMed  Google Scholar 

  • Sokol, P. A., and Woods, D. E., 1983, Demonstration of an iron-siderophore-binding protein in the outer membrane of Pseudomonas aeruginosa, Infect. Immun. 40: 665–669.

    CAS  PubMed  Google Scholar 

  • Sokol, P. A., Lewis, C. J., and Dennis, J. J., 1992, Isolation of a novel siderophore from Pseudomonas cepacia, J. Med. Microbiol. 36: 184–189.

    CAS  PubMed  Google Scholar 

  • Sriyosachati, S., and Cox, C. D., 1986, Siderophore-mediated iron acquisition from transferrin by Pseudomonas aeruginosa, Infect. Immun. 52: 885–891.

    CAS  PubMed  Google Scholar 

  • Stephan, H., Freund, S., Beck, W., Jung, G., Meyer, J. M., and Winkelmann, G., 1993a, Ornibactins-a new family of siderophores from Pseudomonas, Biometals 6: 93–100.

    CAS  PubMed  Google Scholar 

  • Stephan, H., Freund, S., Meyer, J. M., Winkelmann, G., and Jung, G., 1993b, Structure elucidation of the gallium-ornibactin complex by 2D-NMR spectroscopy, Liebigs Ann. Chem. 1993: 43–48.

    Google Scholar 

  • Stewart, G. J., and Sinigalliano, C. D., 1989, Detection and characterization of natural transformation in the marine bacterium Pseudomonas stutzeri strain ZoBell, Arch. Microbiol. 152: 520–526.

    CAS  Google Scholar 

  • Stieritz, D. D., and Holder, I. A., 1975, Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: Description of a burned mouse model, J. Infect. Dis. 131: 668–691.

    Google Scholar 

  • Stintzi, A., 1993, Etude de la voie de biosynthèse de la pyoverdine de Pseudomonas aeruginosa PAO1, Diplôme d’Etudes Approfondies, Université de Strasbourg, France.

    Google Scholar 

  • Stintzi, A., Cornelis, P., Hohnadel, D., Meyer, J. M., Dean, C., Poole, K., Kourambas, S., and Krishnapillai, V., 1996, Novel pyoverdine biosynthesis gene(s) of Pseudomonas aeruginosa, Microbiology 142: 1181–1190.

    CAS  PubMed  Google Scholar 

  • Stoll, A., Brack, A., and Renz, J., 1951, Nocardamin, ein neues antibioticum aus einer Nocardia. Schweiz. Z. Path. Bakteriol. 14: 225–233.

    CAS  Google Scholar 

  • Tabacchioni, S., Bevivino, A., Chiarini, L., Visca, P., and Del Gallo, M., 1993, Characteristic of two rhizosphere isolates of Pseudomonas cepacia and their potential plant-growth-promoting activity, Microb. Releases 2: 161–168.

    CAS  Google Scholar 

  • Tabacchioni, S., Visca, P., Chiarini, L., Bevivino, A., Di Serio, C., Fancelli, S., and Fani, R., 1995, Molecular characterization of rhizosphere and clinical isolates of Burkholderia cepacia, Res. Microbiol. 146: 531–542.

    CAS  PubMed  Google Scholar 

  • Tappe, R., Taraz, K., Budzikiewicz, H., Meyer, J. M., and Lefevre, J. F., 1993, Structure elucidation of a pyoverdin produced by Pseudomonas aeruginosa ATCC 27853, J. Prakt. Chem. 335: 83–87.

    CAS  Google Scholar 

  • Taraz, K., Seinsche, D., and Budzikiewicz, H., 1991a, Pseudobactin-and pseudobactin A-Varianten: Neue peptidsidorephore vom pyoverdin-typ aus Pseudomonas fluorescens “E2”, Z. Naturforsch. 46c: 522–526.

    Google Scholar 

  • Taraz, K., Tappe, R., Schröder, H., Hohlneicher, U., Gwose, I., Budzikiewicz, H., Mohn, G., and Lefèvre, J. F., 1991b, Ferribactins-the biogenetic precursors of pyoverdins, Z. Naturforsch. 46c: 527–533.

    Google Scholar 

  • Taylor, P. C., and Kalamatianos, C. C., 1994, Pseudomonas cepacia in the sputum of cystic fibrosis patients, Pathology 26: 315–317.

    CAS  PubMed  Google Scholar 

  • Teintze, M., and Leong, J., 1981, Structure of pseudobactin A, a second siderophore from plant growth promoting Pseudomonas B10, Biochemistry 20: 6457–6462.

    CAS  PubMed  Google Scholar 

  • Teintze, M., Hossain, M. B., Barnes, C. L., Leong, J., and van der Helm, D., 1981, Structure of ferric pseudobactin, a siderophore from a plant growth promoting Pseudomonas, Biochemistry 20: 6446–6457.

    CAS  PubMed  Google Scholar 

  • Torres, L., Perez-Ortin, J. E., Tordera, V., and Beitran, J. P., 1986, Isolation and characterization of an (FeIII)-chelating compound produced by Pseudomonas syringae, Appl. Environ. Microbiol. 52: 157–160.

    CAS  PubMed  Google Scholar 

  • Tsuda, M., Miyazaki, H., and Nakazawa, T., 1995, Genetic and physical mapping of genes involved in pyoverdin production in Pseudomonas aeruginosa PAO, J. Bacteriol. 177: 423–431.

    CAS  PubMed  Google Scholar 

  • Turfitt, G. E., 1936, Bacteriological and biochemical relationships in the pyocyaneus-fluorescens group. I. The chromogenic function in relation to classification, Biochem. J. 30: 1323–1328.

    CAS  PubMed  Google Scholar 

  • Turfitt, G. E., 1937, Bacteriological and biochemical relationships in the pyocyaneus-fluorescens group. II. Investigation on the green fluorescent pigment, Biochem. J. 31: 212–218.

    CAS  PubMed  Google Scholar 

  • Turfreijer, A., Wibaut, J. P., and Boltjes, T. Y. K., 1938, The green fluorescent pigment of Pseudomonas fluorescens, Rec. Trav. Chim. Pays Bas 57: 1397–1404.

    CAS  Google Scholar 

  • Urakami, T., Ito-Yoshida, C., Araki, H., Kijima, T., Suruki, K.-I., and Komagata, K., 1994, Transfer of Pseudomonas piantarii and Pseudomonas glúmae to Burkholderia spp. and description of Burkholderia vandii sp. nov., Int. J. Syst. Bacteriol. 44: 235–245.

    CAS  Google Scholar 

  • van der Hofstad, G. A. J. M., Marrug, J. D., Verjans, G. M. G. M., and Weisbeek, P. J., 1986, Characterization and structural analysis of the siderophore produced by the PGPR Pseudomonas putida strain WCS358, in: Iron, Siderophores, and Plant Diseases (T. R. Swinburne, ed.), Plenum Press, New York, pp. 71–75.

    Google Scholar 

  • Venturi, V., Ottevanger, C., Leong, J., and Weisbeek, P. J., 1993, Identification and characterization of a siderophore regulatory gene (pfrA) of Pseudomonas putida WCS358: Homology to the alginate regulatory gene algQ of Pseudomonas aeruginosa, Mol. Microbiol. 10: 63–73.

    CAS  PubMed  Google Scholar 

  • Venturi, V., Wolfs, K., Leong, J., and Weisbeek, P. J., 1994, Amplification of the groESL operon in Pseudomonas putida increases siderophore gene promoter activity, Mol. Gen. Genet. 245: 126–132.

    CAS  PubMed  Google Scholar 

  • Venturi, V., Weisbeek, P. J., and Koster, M., 1995a, Gene regulation of siderophore-medi-ated iron acquisition in Pseudomonas: Not only the Fur repressor, Mol. Microbiol. 17: 603–610.

    CAS  PubMed  Google Scholar 

  • Venturi, V., Ottevanger, C., Bracke, M., and Weisbeek, P. J., 1995b, Iron regulation of siderophore biosynthesis and transport in Pseudomonas putida WCS358: Involvement of a transcriptional activator and of the Fur protein, Mol. Microbiol. 15: 1081–1093.

    CAS  PubMed  Google Scholar 

  • Visca, P., Serino, P., and Orsi, N., 1992a, Isolation and characterization of Pseudomonas aeruginosa mutants blocked in the synthesis of pyoverdin, J. Bacteriol. 174: 5727–5731.

    CAS  PubMed  Google Scholar 

  • Visca, P., Colotti, G., Serino, L., Verzili, D., Orsi, N., and Chiancone, E., 1992b, Metal regulation of siderophore synthesis in Pseudomonas aeruginosa and functional effects of siderophore-metal complexes, Appl. Environ. Microbiol. 58: 2886–2893.

    CAS  PubMed  Google Scholar 

  • Visca, P., Ciervo, A., Sanfilippo, V., and Orsi, N., 1993, Iron-regulated salicylate synthesis by Pseudomonas spp, J. Gen. Microbiol. 139: 1995–2001.

    CAS  PubMed  Google Scholar 

  • Visca, P., Ciervo, A., and Orsi, N., 1994, Cloning and nucleotide sequence of the pvdA gene encoding the pyoverdin biosynthetic enzyme L-ornithine N 5-oxygenase in Pseudomonas aeruginosa, J. Bacteriol. 176: 1128–1140.

    CAS  PubMed  Google Scholar 

  • Waring, W. S., and Werkman, C. H., 1942, Growth of bacteria in an iron-free medium, Arch. Biochem. 1:303–310.

    CAS  Google Scholar 

  • Weinberg, E. D., 1978, Iron and infection, Microbiol. Rev. 42: 45–66.

    CAS  PubMed  Google Scholar 

  • Weinberg, E. D., 1993, The iron-withholding defense system, ASM News 59: 559–562.

    Google Scholar 

  • Wiebe, C., and Winkelmann, G., 1975, Kinetics studies on the specificity of chelate iron uptake in Aspergillus, J. Bacteriol. 123: 837–842.

    CAS  PubMed  Google Scholar 

  • Williams, P., Morton, D. I., Towner, K.J., Stevenson, P., and Griffiths, E., 1990, Utilization of enterobactin and other exogenous iron sources by H. parainfluenzae, and H. paraprophilus, J. Gen. Microbiol. 136: 2343–2350.

    CAS  PubMed  Google Scholar 

  • Winkler, S., Ockels, W., Budzikiewicz, H., Korth, H., and Pulverer, G., 1986, 2-hydroxy-4-methoxy-5-methylpyridin-N-oxid, ein Al3+ bindender metabolit von Pseudomonas cepacia, Z. Naturforsch. 41c: 807–808.

    Google Scholar 

  • Winkelmann, G., 1991, Handbook of Microbiol Iron Chelates, CRC Press, Boca Raton, Florida, USA.

    Google Scholar 

  • Wolz, C., Hohloch, K., Ocaktan, A., Poole, K., Evans, R. W., Rochel, N., Albrecht-Gary, A. M., Abdallah, M. A., and Döring, G., 1994, Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa, Infect. Immun. 62: 4021–4027.

    CAS  PubMed  Google Scholar 

  • Xiao, R., and Kisaalita, W. S., 1995, Purification of pyoverdines of Pseudomonas fluorescens 2-79 by copper-chelate chromatography, Appl. Environ. Microbiol. 61: 3769–3774.

    CAS  PubMed  Google Scholar 

  • Xu, G.-W., and Gross, D. C., 1988, Physical and functional analyses of the syrA and syrB genes involved in syringomycin production by Pseudomonas syringae pv. syringae, J. Bacteriol 170: 5680–5688.

    CAS  PubMed  Google Scholar 

  • Yabuuchi, E., Kosako, Y., Oyaizu, H., Yano, L., Hotta, H., Hashimoto, Y., Ezaki, T., and Arakawa, M., 1992, Proposal of Burkholderia gen. nov. and transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia cepacia (Palleroni and Holmes, 1981) comb, nov., Microbiol. Immunol. 36: 1251–1275.

    CAS  PubMed  Google Scholar 

  • Yamada, Y., Seki, N., Kitahara, T., Takahashi, M., and Matsui, M., 1970, Structure and synthesis of aeruginoic acid[2-(o-hydroxypheyl)-4-thiazolecarboxylic acid], Agric. Biol. Chem. 34: 780–783.

    CAS  Google Scholar 

  • Yamano, Y., Nishikawa, T., and Komatsu, Y., 1994, Ferric iron transport system of Pseudomonas aeruginosa PAO1 that functions as the uptake pathway of a novel catechol-substituted cephalosporin, S-9096, Appl. Microbiol. Biotechnol. 40: 892–897.

    CAS  Google Scholar 

  • Yang, C.-C., and Leong, J., 1984, Structure of pseudobactin 7SR1, a siderophore from a plant-deleterious Pseudomonas. Biochemistry 23: 3534–3540.

    CAS  PubMed  Google Scholar 

  • Yang, H., Chaowagul, W., and Sokol, P. A., 1991, Siderophore production by Pseudomonas pseudomallaei, Infect. Immun. 59: 776–780.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Meyer, JM., Stintzi, A. (1998). Iron Metabolism and Siderophores in Pseudomonas and Related Species. In: Montie, T.C. (eds) Pseudomonas. Biotechnology Handbooks, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0120-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0120-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0122-4

  • Online ISBN: 978-1-4899-0120-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics