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Pseudomonas pp 35–72Cite as

Carbohydrate Catabolism in Pseudomonas aeruginosa

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Part of the book series: Biotechnology Handbooks ((BTHA,volume 10))

Abstract

The goal of this review is to update the reader on recent data elucidating the physiology and genetics of glycolytic pathways in P. aeruginosa, the most thoroughly investigated member of the pseudomonads. Glycolytic pathways in this organism have several unique features. Lacking phosphofructokinase, P. aeruginosa metabolizes three- and six-carbon sugars via a central cycle which includes the Entner-Doudoroff pathway (EDP) enzymes, rather than utilizing the fermentation pathway of Embden-Meyerhoff-Parnas (EMP) (Entner and Doudoroff, 1952; Kersters and DeLey, 1968). Another unique physiological feature is that a product of the EDP, glyceraldehyde 3-phosphate, is largely recycled through the central cycle, rather than continuing to pyuvate via the lower EMP pathway (Banerjee, 1989; Phibbs, 1988). Thus, the latter enzymes in P. aeruginosa seem to serve gluconeogenic rather than the more usual catabolic functions in other organisms. Whereas the metabolism of glucose is preferred by Escherichia coli, P. aeruginosa utilizes succinate and other tricarboxylic acid cycle intermediates before glucose (Anderson and Wood, 1969; Belvins et al., 1975; Hylemon and Phibbs, 1972; Midgley and Dawes, 1973; and Tiwari and Campbell, 1969). In addition, this organism lacks an oxidative hexose monophosphate pathway (Phibbs, 1988).

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Authors and Affiliations

  1. Department of Biology, Drew University, Madison, New Jersey, 07940, USA

    Louise M. Temple

  2. Worldwide Microbiology Group, Millipore Corp., Bedford, Massachusetts, 01730, USA

    Andrew E. Sage

  3. Department of Microbiology, Colorado State University College of Veterinary Medicine, Fort Collins, Colorado, 80523, USA

    Herbert P. Schweizer

  4. Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, North Carolina, 27858, USA

    Paul V. Phibbs Jr.

Authors
  1. Louise M. Temple
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  2. Andrew E. Sage
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  3. Herbert P. Schweizer
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  4. Paul V. Phibbs Jr.
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Editors and Affiliations

  1. University of Tennessee, Knoxville, Tennessee, USA

    Thomas C. Montie

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Temple, L.M., Sage, A.E., Schweizer, H.P., Phibbs, P.V. (1998). Carbohydrate Catabolism in Pseudomonas aeruginosa . In: Montie, T.C. (eds) Pseudomonas. Biotechnology Handbooks, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0120-0_2

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  • DOI: https://doi.org/10.1007/978-1-4899-0120-0_2

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