Abstract
Extracellular myeloperoxidase (MPO) is a macrophage modulator which stimulates release of the pro-inflammatory cytokine TNFα in addition to reactive oxygen species (ROS) generated by these cells. MPO-induced macrophage secretion of pro-inflammatory mediators indirectly upregulates neutrophil pro-inflammatory capacity through contributing to neutrophil priming for respiratory burst activity. However, to date the question concerning a direct influence on the neutrophil by MPO or the MPO-derived product hypochlorous acid (HOCl) remains to be elucidated. Taurine, the most abundant free amino acid in human neutrophils acts as an antioxidant through the formation of taurine-chloramine by sequestering HOCl. Zinc also has antioxidant properties and taurine-zinc complexes have been shown to have greater efficacy than either agent alone in protection against ROS-mediated tissue damage. The aims of this study were: (a) to determine if extracellular MPO modulates the inflammatory response through autocrine feedback on the neutrophil and to investigate if taurine either directly or indirectly through taurine-chloramine formation may further influence this pathway and (b) to evaluate the efficacy of a taurine-zinc combination in modulating MPO-induced CD11b receptor expression.
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References
Bray, T.M. and Bettger, W.J., 1990, The Physiological Role of Zinc as an Antioxidant, Free Radical Biology Medicine, 8:281–291.
Carey, P.D., Byrne, K., Jenkins, J.K., Sielaff, T.D., Walsh, C.J., Fowler, A.A., and Sugerman, H.J., 1990, Ibuprofen attenuates hypochlorous acid production from neutrophils in porcine acute lung injury, J Surg. Tres., 49:262–270.
Carey, P.D., Wakefield, C.H., Thayeb, A., Monson, J.R.T., Darzi, A., and Guillou, P.J., 1994, Effects of minimally invasive surgery on hypochlorous acid production by neutrophils, Br. J. Surg., 81:557–560.
Chopp, M., Zhang, R.L., Chen, H., Li, Y., Jiang, N., and Rusche, J.S., 1994, Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats, Stroke, 25:869–875.
Chvapil, M., 1973, New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes, Life Sci., 13:1041–1049.
Couser, W.G., 1993, Mediation of immune glomeruli injury, Clin. Investig., 71:808–811.
Davies, J. M. S., Horwitz, D. A., and Davies, K. J. A., 1994, Inhibition of collagenase activity by N-chlorotaurine, a product of activated neutrophils, Arthritis and Rheumatism, 37:424–427.
Fukuda, K., Hirai, Y., Yoshida, H., Nakajima, T., and Usai, T., 1982, Free Amino Acid Content of Lymphocytes and Granulocytes Compared, Clin Chem, 28:1758–1761.
Langdale, L.A., Flaherty, L.C., Liggitt, H.D., Harlan, J.M., Rice, C.L., and Winn, R.K., 1993, Neutrophils contribute to hepatic ischemia-reperfusion injury by a CD18-independent mechanism, J. Leuko. Biol., 53:511–517.
Lampert, M.B. and Weiss, S.J., 1983, The chlorinating potential of the human monocyte, Blood, 62:645–651.
Lefkowitz, D.L., Mills, K.C., Moguilevsky, N., Bollen, A., Vaz, A., and Lefkowitz, S., 1993, Regulation of macrophage function by human recombinant myeloperoxidase, Immunology Letters 36:43–50.
Lin, Y. Y., Wright, C. E., Zagorski, M., and Nakanishi, K., 1988, 13C-NMR study of taurine and chlorotaurine in human cells, Biochim. Biophys. Acta, 969:242–248.
Marcinkiewicz, J., Grabowska, A., Bereta, J., and Stelmaszynska, T., 1995, Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generaton of nitric oxide and other macrophage inflammatory mediators, J. Leuko. Biol., 58:667–674.
McLoughlin, D.M., Stapleton, P.P., and Bloomfield, F.J., 1991, Influence of taurine and a substituted taurine on the respiratory burst pathway in the inflammatory response, Biochem. Soc. Trans., 19:73–78.
Park, E., Quinn, M. R., Wright, C. E., and Schuller-Levis, G., 1993, Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells, J. Leuko. Biol., 54:119–124.
Pasantes-Morales, H., Wright, C.E., and Gaull, G.E., 1984, Protective effect of taurine, zinc and tocopheral on retinol-induced damage in human lymphoblastoid cells, J. Nutr., 114:2256–2261.
Pasantes-Morales, H., and Cruz C., 1984, Protective effect of taurine and zinc on peroxidation-induced damage in photoreceptor outer segments, J. Neurosci. Res., 11:303.
Pou, S., Gunther, M.R., Pou, W.S., Cao, G.L., Bater, J.M., Cohen, M.S., Burch, R. M., and Rosen, G.M., 1993, Effect of NP. 15669, an inhibitor of neutrophil recruitment and neutrophil-mediated inflammation, on neutrophil function in vitro, Biochem. Pharmacol., 45:2123-2127.
Stapleton, PP. and Bloomfield, FJ., 1993, Effect of zwitterions on the respiratory burst, J. Biomed. Sci., 3:79–84.
Stendahl, O., Coble, B-L, Dahlgren, C., Hed, J., and Molin, L., 1984, Myeloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient, J. Clin. Invest. 73:366–373.
Thomas, E. L., 1979, Myeloperoxidase-hydrogen peroxide-chloride antimicrobial system: Effect of exogenous amines on anti-bactericidal action against Escherichia coli, Infect. Immun., 25:110–116.
Weiss, S.J., Klein, R., Slivka, A., and Wei, W., 1982, Chlorination of taurine by human neutrophils evidence for hypochlorous acid generation, J. Clin. Invest., 70:598–607.
Weiss, S.J., 1989, Tissue destruction by neutrophils, New Engl. J. Med., 320:365–376.
Wright, C.E., Tallan, H.H., Lin, Y.Y., and Gaull, G.E., 1986, Taurine: Biological update, 55:427–453.
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Stapleton, P.P., Redmond, H.P., Bouchier-Hayes, D.J. (1998). Myeloperoxidase (MPO) May Mediate Neutrophil Adherence to the Endothelium through Upregulation of CD11b Expression - An Effect Downregulated by Taurine. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_24
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DOI: https://doi.org/10.1007/978-1-4899-0117-0_24
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