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Vaccine Design pp 1–9Cite as

The Role of Cytokines in the Action of Immunological Adjuvants

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Part of the book series: NATO ASI Series ((NSSA,volume 293))

Abstract

Three classes of adjuvants - mineral oil emulsions, aluminium salts, and saponin - have long been used to augment immune responses in vaccination. Each has its own advantages and limitations, and during the last decade new adjuvants have been developed. These complement a new group of antigens, including proteins produced by recombinant technology and synthetic peptides, which require adjuvants to elicit protective immune responses. Some of the recently developed adjuvant formulations are already approved for use in human and veterinary vaccines. This paper describes immunomodulating bacterial products and synthetic derivatives, as well as two-phase (lipid in water) vehicles for antigens. It also reviews briefly what adjuvants are required to do and what is known of their mode of action, with special reference to the role of cytokines.

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References

  • Allison, A.C. and Davies, A.J.S. 1971. Requirement of thymus-dependent lymphocytes for potentiation by adjuvants of antibody formation. Nature. 233: 330.

    Article  PubMed  CAS  Google Scholar 

  • Allison, A.C. and Gregoriadis, G. 1974. Liposomes as immunological adjuvants. Nature. 252: 252.

    Article  PubMed  CAS  Google Scholar 

  • Allison, A.C. and Byars, N.E. 1986. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and cell-mediated immunity. J. Immun. Methods. 2: 369.

    Google Scholar 

  • Allison, A.C. and Byars, N.E. 1992. Adjuvants for a new generation of vaccines. Can. J. Infect. Dis., 3: 84B.

    Google Scholar 

  • Audibert, F.M. and Lise, L.D. 1993. Adjuvants: current status, clinical perspectives and future prospects. Immunol. Today. 14: 281.

    Article  PubMed  CAS  Google Scholar 

  • Byars, N.E., Fraser-Smith, E.B., Pecyk, R.A. et al. 1994. Vaccinating guinea pigs with recombinant glycoprotein D of herpes simplex virus in an efficacious adjuvant formulation elicits protection against vaginal infection. Vaccine. 12: 200.

    Article  PubMed  CAS  Google Scholar 

  • Cumberpatch, M. and Kimber, I. 1995. Tumour necrosis factor-α is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology. 84: 31.

    Google Scholar 

  • Dempsey, P.W., Allison, M.E.D., Akkaraju, S., Goodnow, C.C. and Fearon, D.T. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science. 271: 348.

    Article  PubMed  CAS  Google Scholar 

  • Doherty, P.C., Allen, W., Eichelberger, M. and Carding, S.R. 1992. Roles of ab and gd T-cell subsets in viral immunity. Annu. Rev. Immunol. 10: 123.

    Article  PubMed  CAS  Google Scholar 

  • Ellouz, F., Adam, A., Ciorbaru, R. and Lederer, E. 1974. Minimal structural requirements for adjuvant activity of bacterial peptidoglycans. Biochem. Biophys. Res. Comm., 59: 1317.

    Article  PubMed  CAS  Google Scholar 

  • Finkelman, F.D., Holmes, J., Katona, I.M. et al. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol., 8: 303.

    Article  PubMed  CAS  Google Scholar 

  • Glück, R. 1995. Liposomal presentation of antigens for human vaccines, in: Powell, M.F., Newman, M.F. (eds.). Vaccine Design: The Subunit and Adjuvant Approach. Plenum Press, New York 1995; pp 325.

    Google Scholar 

  • Gregoriadis, G. 1990. Immunological adjuvants: A role for liposomes. Immunol. Today. 11: 89.

    Article  PubMed  CAS  Google Scholar 

  • Gregoriadis, G., Wang, Z., Barenholz, Y. and Francis, M.J. 1993. Liposome-entrapped T-cell peptide provides help for a co-entrapped B-cell peptide to overcome genetic restriction in mice and induce immunological memory. Immunology. 80: 535.

    PubMed  CAS  Google Scholar 

  • Hamaoka, T., Katz, D.H., Benacerraf, B. 1973. Hapten-specific antibody responses in mice. II. Cooperative interactions between adoptively transferred T-and B-lymphocytes in the development of an IgE response. J. Exp. Med., 138: 538.

    Article  PubMed  CAS  Google Scholar 

  • Heufler, C., Koch, F. and Schüler, G. 1988. Granulocyte/macrophage colony-stimulating factor and interleukin-1 mediate the maturation of epidermal Langerhans cells into potent immunostimulatory dendritic cells. J. Exp. Med., 167: 700.

    Article  PubMed  CAS  Google Scholar 

  • Kaminski, M.S., Kitamura, K. and Maloney, D.G. 1986. Importance of antibody isotype in monoclonal anti-idiotype therapy of murine B-cell lymphoma. A study of hybridoma class switch variants. J. Immunol., 136: 1123.

    PubMed  CAS  Google Scholar 

  • Kenney, J.S., Hughes B.M. and Allison, A.C. 1989. Determination of antibody affinity and concentration by solution-phase microradioimmunoassay, in: Zola, H. (ed.) Laboratory Methods in Immunology. CRC Press, Boca Raton; pp 209.

    Google Scholar 

  • Kenney, J.S., Hughes, B.W., Masada, M.P. and Allison, A.C. 1989. Influence of adjuvants on the quantity, affinity, isotype and epitope specificity of murine antibodies. J. Immunol. Methods. 21: 157.

    Article  Google Scholar 

  • Macatonia, S.E., Hosken, N.A., Litton, M., Vieira, P., Hsieh, C.-S., culpepper, J.A., Wysocka, M., Trinchieri, G., Murphy, K.M. and O’Garra, A. 1995. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T-cells. J. Immunol. 154: 5071.

    PubMed  CAS  Google Scholar 

  • MacLennan, I.C.M. 1994. Germinal centers. Annu. Rev. Immunol., 12: 117.

    Article  PubMed  CAS  Google Scholar 

  • Meeusen, E.N.T., Premier, R.R. and Brandon, M.R. 1996. Tissue-specific migration of lymphocytes: a key role for Th1 and Th2 cells? Immunol. Today. 17: 421.

    Article  PubMed  CAS  Google Scholar 

  • Persson, G.R., Engel, D., Whitney, C., Darueau, R., Weinberg, A., Brunsvold, M. and Page, R.C. 1994. Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect. Immun., 62: 1026.

    PubMed  CAS  Google Scholar 

  • Reichmann, L., Clark, M., Waldmann, H. and Winter, G. 1988. Reshaping human antibodies for therapy. Nature. 332: 323.

    Article  Google Scholar 

  • Ribi, E., Ulrich, J.T. and Masihi, K.N. 1993. Immunopotentiating activities of monophosphoryl lipid A, in: Majde, J.A. (ed.) Immunopharmacology of Infectious Diseases: Vaccine Adjuvants and Modulation of Non-specific Resistance. Alan R. Liss, New York; pp 101.

    Google Scholar 

  • Ron, Y. and Sprent, J. 1987. T-cell priming in vitro: A major role for B-cells in presenting antigen to T-cells in lymph nodes. J. Immunol., 138: 2848.

    PubMed  CAS  Google Scholar 

  • Rothel, J.S., Corner, L.A., Seaw, H.-F., Wood, P.R. and Lightowlers, M.W. 1996. Antigen-specific IgA secreting cells induced by peripheral vaccination. Immunol. Cell. Biol., 74: 278.

    Article  Google Scholar 

  • Schijns, V.E.C.J., Haagmans, B., Rijke, E.O., Huang, S., Aguet, M. and Horzunek, M.C. 1994. IFN-y receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J. Immunol. 153: 2029.

    PubMed  CAS  Google Scholar 

  • Schulz, M., Zinkernagel, R.M. and Hengartner, H. 1991. Peptide-induced protection by cytotoxic T-cells. Proc. Natl. Acad. Sci. USA. 88: 991.

    Article  PubMed  CAS  Google Scholar 

  • Spitznagel, J.K. and Allison, A.C. 1970. Mode of action of adjuvants: effects on antibody responses to macrophages-associated bovine serum albumin. J. Immunol. 104: 128.

    PubMed  CAS  Google Scholar 

  • Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9: 271.

    Article  PubMed  CAS  Google Scholar 

  • Strobl, H., Riedl, E., Scheinecker, G, Bello-Fernandez, G, Pickl, W.F., Rappersberger, K., Majdic, O. and Knapp., W. 1996. TGF-β1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors. J. Immunol. 157: 1499.

    PubMed  CAS  Google Scholar 

  • Szakal, A.K., Kosco, M.H. and Tew, J.G. 1989. Microanatomy of lymphoid tissue during humoral immune responses: Structure-function relationships. Annu. Rev. Immunol. 7: 91.

    Article  PubMed  CAS  Google Scholar 

  • Toes, R.E.M., Blom, R.J.J., Offringa, R., Kast, W.M. and Melief, C.J.M. 1996. Enhanced tumor outgrowth after peptide vaccination. J. Immunol. 156: 3911.

    PubMed  CAS  Google Scholar 

  • Unanue, E.R., Askonas, B.A. and Allison, A.C. 1969. A role of macrophages in the stimulation of immune responses by adjuvants. J. Immunol. 103: 71.

    PubMed  CAS  Google Scholar 

  • Van Rooijen, N. and Sanders, A. 1994. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J. Immunol Methods. 174: 83.

    Article  PubMed  Google Scholar 

  • Vijay, H.M., Lavregne, G., Huang, H. and Bernstein, I.L. 1979. Preferential synthesis of IgE reaginic antibodies in rats immunized with alum adsorbed antigens. Int. Arch. Allergy Appl. Immunol. 59: 227.

    Article  PubMed  CAS  Google Scholar 

  • Walker, B.D., Flexner, C. and Paradis, T.J. 1988. HIV-1 reverse transcriptase is a target for cytotoxic T-lymphocytes in infected individuals. Science. 240: 64.

    Article  PubMed  CAS  Google Scholar 

  • Waters, R.V., Terrell, T.G. and Jones, G.H. 1986. Uveitis induction in the rabbit by muramyl dipeptides. Infect. Immun., 51: 816.

    PubMed  CAS  Google Scholar 

  • White, R.G. 1976. The adjuvant effect of microbial products on the immune response. Rev. Microbiol., 30: 579.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Dawa Corporation, Belmont, CA, 94002, USA

    Anthony C. Allison

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  1. Anthony C. Allison
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Editors and Affiliations

  1. School of Pharmacy, University of London, London, England

    Gregory Gregoriadis  & Brenda McCormack  & 

  2. Dawa Corporation, Belmont, California, USA

    Anthony C. Allison

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© 1997 Springer Science+Business Media New York

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Allison, A.C. (1997). The Role of Cytokines in the Action of Immunological Adjuvants. In: Gregoriadis, G., McCormack, B., Allison, A.C. (eds) Vaccine Design. NATO ASI Series, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0062-3_1

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  • DOI: https://doi.org/10.1007/978-1-4899-0062-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0064-7

  • Online ISBN: 978-1-4899-0062-3

  • eBook Packages: Springer Book Archive

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