Abstract
The goal of neuroimaging techniques is to provide realistic maps of the neuronal populations that become active during particular functional tasks. Most non-invasive neuroimaging techniques (PET, fMRI, NIRS, optical imaging) measure regional cerebral blood flow or metabolism. The coupling between regional blood flow and local energy consumption was first shown by the deoxyglucose method (Sokoloff et al., 1977). How the activity related vascular and metabolic recruitment reflects the underlying synpatic processes was studied by optical reflectance methods (Grinvald et al., 1986, 1991 and their relation to electrophysiological measures (Frostig et al., 1990; Narayan et al., 1994).
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Azari, N.P., Pettigrew, K.D., Schapiro, M.B., Haxby, J.V., Grady, C.L., Pietrini, P., Salerno, J.A., Heston, L.L., Rapoport, S.I., Horwitz, B. 1993. Early detection of Alzheimer’s disease: A statistical approach using positron emission tomographic data. J. Cereb. Blood Flow Metab. 13, 438–447.589, 279-290.
Baron, J.C., Frackowiack, R.S.J., Herholz, K., Jones, T., Lammertsma, A.A., Mazoyer, B., Wienhard, K. 1989. Use of PET methods for measurement of cerebral energy metabolism and hemodynamics in cerebrovascular disease. J. Cereb. Blood Flow Metab. 9, 723–742.
Boecker, H., Kleinschmidt, A., Requardt, M., Hänicke, W., Merboldt, K.D., Frahm, J. 1994a. Functional cooperativity of human cortical motor areas during self-paced simple finger movements. Brain 117:1231–39d.
Carman, G.J., Drury, H.A., van Essen, D.C. 1995. Computational methods for reconstructing and unfolding the cerebral cortex. Cerebral Cortex 5:506–517.
Cohen, M.S., Bookheimer, S.Y. 1994. Localization of brain function using magnetic resonance imaging. Trends Neurosci. 17:268–277.
Fox, P.T., Raichle, M.E., Mintun, M.A., Dence, C. 1988. Non-oxidative glucose consumption during focal physiologic neural activity. Science 241:462–464.
Friston, K.J., Frith, CD., Turner, R., Frackowiak, R.S.J. 1995. Characterizing evoked hemodynamics with fMRI. Neuroimage 2, 157–165.
Friston, K.J., Frith, CD., Frackowiak, R.S.J., Turner, R. 1995. Characterizing dynamic brain responses with fMRI: a multivariate approach. Neuroimage 2, 166–172.
Frostig, R.D., Lieke, E.E., Ts’o, D.Y., Grinvald, A. 1990. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of instrinsic signals. Proc. Natl. Acad. Sc. USA 87:6082–6086.
George, J.S., Aine, C.J., Mosher, J.C., Schmidt, D.M., Ranken, D.M., Schlitt, H.A., Wood, C.C., Lewine, J.D., Sanders, J.A., Belliveau, J.W. 1995. Mapping function in the human brain with magnetoencephalography, anatomical magnetic resonance imaging and functional magnetic resonance imaging. J. Clinical Neurophysiology 12:406–431.
Giesen, H.-J. v., Schlaug, G., Steinmetz, H., Benecke, R., Freund, H.-J., Seitz, R. 1994. Cerebral network underlying unilateral motor neglect: evidence from positron emission tomography. J. Neurological Sciences 125, 29–38.
Grinvald, A., Lieke, E., Frostig, R.D., Gilbert, CD., Wiesel, T.N. 1986. Functional architecture of cortex revealed by optical imaging of instrinsic signals. Nature 324:361–364.
Grinvald, A., Frostig, R.D., Siegel, R.M., Bartfeld, E. 1991. High-resolution optical imaging of functional brain architecture in the awake monkey. Proc. Natl. Acad. Sci. USA 88:11559–11563.
Haglund, M.M., Ojemann, G.A., Hochman, D.W. 1992. Optical imaging of epileptiform and functional activity in human cerebral cortex. Nature 358:668–671.
Heiss, W.-D., Huber, M., Fink, G.R., Herholz, K., Pietrzyk, U., Wagner, R., Wienhard, K. 1992. Progressive derangement of periinfarct viable tissue in ischemic stroke. J. Cereb. Bloof Flow Metab. 12, 193–203.
Herholz, K., Heindel, W., Luyten, P.R., den Hollander, J.A., Pietrzyk, U., Voges, J., Kugel, H., Friedmann, G., Heiss, W.-D. 1992. In vivo imaging of glucose consumption and lactate concentration in human gliomas. Ann. Neurol. 31, 319–327.
Leniger-Follert, A., Hossmann, K. 1979. Simultaneous measurement of microflow and evoked potentials in the somatomotor cortex of the cat brain during specific sensory activation. Pfluegers Arch. 380:85–89.
Narayan, S.M., Santori, E.M., Toga, A.W. 1994. Mapping functional activity in rodent cortex using optical intrinsic signals. Cerebral Cortex 4:195–204.
Sanes, J.N., Donoghue, J.P., Thangaraj, V., Edelman, R.R., Warach, S. 1995. Shared neural substrates controlling hand movements in human motor cortex. Science 268:1775–77.
Seitz, R., Huang, Y., Knorr, U., Teilmann, L., Herzog, H., Freund, H.-J. 1995. Large-scale plasticity of the human motor cortex. NeuroReport 6, 742–744.
Sitzer, M., Knorr, U., Seitz, R.J. 1994. Cerebral hemodynamics during sensorimotor activation in humans. J. Appl. Physiol. 77, 2804–2811.
Sokoloff, L., Reivich, M. Kennedy, C, des Rosiers, M.H., Patalak, C.S., Pettigrew, K.D., Sakurada, O., Shinohara, J. 1977. The 14C-Deoxyglucose method for the measurement of local cerebral glucose utilization. Theory, procedure and normal values in the conscious and anestetized albino rat. J. Neurochem. 28:897–916.
Steinmetz, H., Seitz, R.J. 1991. Functional anatomy of language processing: Neuroimaging and the problem of individual variability. Neuropsychologia 29, 1149–1161.
Swanson, L.W. 1995. Mapping the human brain: past, present and future. TINS 18:471–474.
Turner, R. 1994. Magnetic resonance imaging of brain functions. Ann. Neurol. 35:637–638.
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Freund, HJ. (1997). What Do We Expect from Non-Invasive Functional Neuroimaging?. In: Villringer, A., Dirnagl, U. (eds) Optical Imaging of Brain Function and Metabolism 2. Advances in Experimental Medicine and Biology, vol 413. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0056-2_27
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DOI: https://doi.org/10.1007/978-1-4899-0056-2_27
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