Abstract
The idea that electrical activity is coupled to microvascular changes is not new. Already a century ago, Roy and Sherrington (1890) postulated that “the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity”. Later studies have indeed demonstrated that there is a strong coupling between neuronal activity, local metabolic activity, and blood flow (Kety et al., 1955; Lassen and Ingvar 1961; Sokoloff, 1977; Raichle et al., 1983; Fox et al., 1986). Modern neuroimaging techniques have used signals that originate from metabolic activity or vascular response because the monitoring and precise localization of such signals sources is often better than those which originate directly from electrical activity.
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© 1997 Springer Science+Business Media New York
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Malonek, D., Grinvald, A. (1997). Vascular Regulation at Sub Millimeter Range. In: Villringer, A., Dirnagl, U. (eds) Optical Imaging of Brain Function and Metabolism 2. Advances in Experimental Medicine and Biology, vol 413. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0056-2_24
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DOI: https://doi.org/10.1007/978-1-4899-0056-2_24
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