Abstract
The classical model of neuronal metabolism holds that changes in local neuronal activity are reflected in changes of blood flow (rCBF) and oxygen metabolism (rCMRO2). This model has been examined in human PET [1,2] and animal [3] studies.
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References
P. Fox, M. Raichle, M. Mintun, and C. Dence. Nonoxidative glucose consumption during focal physiologic neural activity. Sczence, 241:462–464, 1988.
P. Fox and M. Raichle. Focal physiological uncoupling of blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Sciences, 83:1140–1144, 1986.
R. F. Ackermann and J. L. Lear. Glycolysis-induced discordance between glucose metabolic rates measured with radiolabelled fluorodeoxyglucose and glucose. Journal of Cerebral Blood Flow and Metabolism, 9(6):774–785, 1989.
S. Marrett, H. Fujita, E. Meyer, L. Ribeiro, A. C. Evans. H. Kuwabara and A. Gjedde. Stimulus specific increase of oxidative metabolism in human visual cortex. Quantification of Brain Function, pg. 217–228, 1993.
G. M. Hathout, K. A. Kirlew, G. J. So, D. R. Hamilton, J. X. Zhang, U. Sinha, S. Sinha, J. Sayre, D. Gozal, R. M. Harper, and a. 1. et. MR imaging signal response to sustained stimulation in human visual cortex. Journal of Magnetic Resonance Imaging, 4(4):53743, Jul–Aug 1994.
G. Kruger, J. Frahm, K. Merboldt, and A. Kleinschmidt. Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activa tion in man. In Proceedings of the Annual Meeting, Nice, France, August 1995. Society for Magnetic Resonance.
R. B. H. Tootell, M. S. Silverman, S. L. Hamilton, E. Switkes, R. L. De-Valois. Functional anatomy of macaque striate cortex. V. Spatial frequency. Journal of Neuroscience, 8(5):1610–1624, 1988.
S. Ohta, E. Meyer, C. Thompson, and A. Gjedde. Oxygen consumption of the living human brain measured during a single inhalation of radioactive oxygen. Journal of Cerebral Blood Flow and Metabolism, 12:179–192, 1992.
D. Collins, P. Neelin, T. Peters, and A. Evans. Automatic 3d intersubject registration of MR volumetric data in standardized talairach space. Journal of Computer Assisted Tomography, 18(2):192–205, 1994.
J. Talairach and P. Tournoux. Co-planar stereotactic atlas of the human brain:3-Dimensional proportional system. Thieme Verlag, Stuttgart/New York, 1988.
R. Woods, J. Mazziotta, and S. Cherry. MRI-PET registration with an automated algorithm. Journal of Computer Assisted Tomography, 17(4):536–546, 1993.
P. Fox and M. Raichle. Stimulus rate determines regional blood flow in striate cortex. Annals of Neurology, 17(3):303–305, March 1985.
K. Worsley, A. Evans, S. Marrett, and P. Neelin. Determining the number of statistically significant areas of activation in subtracted activation studies from PET. Journal of Cerebral Blood Flow and Metabolism, 12(6):900–918, 1992. au14_P. Fox and M. Raichle. Stimulus rate dependance of regional blood flow in human striate cortex, demonstrated by positron emission tomography. Journal of Neurophysyiology, 51:1109–1120, 1984.
F. Caramia, R. Tootell, K. Kwong, J. Reppas, B. Rosen, and B. Jenkins. Comparison of MRI signal changes produced by stimuli selective for blob versus inter-blob cells in vl. In Proceedings of the Annual Meeting, Nice, France, August 1995. Society for Magnetic Resonance.
P. A. Bardelting, T. L. Davis, K. K. Kwong, P. T. Fai, A. Jiang, J. R. Baker, J. W. Bellrean, R. M. Weiskoff and B. R. Rosen. fMRI and PET demonstrate Sustained Blood oxygenation and flow enhancement during extended Visual Stimulation Duration. Proceeding of The Society of Magnetic Resonance, Nice, France 1995.
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Marrett, S., Gjedde, A. (1997). Changes of Blood Flow and Oxygen Consumption in Visual Cortex of Living Humans. In: Villringer, A., Dirnagl, U. (eds) Optical Imaging of Brain Function and Metabolism 2. Advances in Experimental Medicine and Biology, vol 413. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0056-2_22
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DOI: https://doi.org/10.1007/978-1-4899-0056-2_22
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