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Viral Infections of Humans pp 455–471Cite as

Human Herpesvirus-6 and Human Herpesvirus-7

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Abstract

Human herpesvirus type 6 (HHV-6) and human herpes-virus type 7 (HHV-7) are two of the most recently characterized viruses in the group that includes herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), varicellazoster (HHV-3), Epstein—Barr virus (EBV) (HHV-4), cytomegalovirus (CMV) (HHV-5), and the Kaposi’s sarcoma-associated herpesvirus HHV-8.(33a,97a) The impact of HHV-6 and HHV-7 on the human population is largely unknown, although HHV-6 is generally accepted as the primary cause of roseola or exanthem subitum,(158,172) may be the most common pathogenic virus infecting infants and young children,(123,126) and also is etiologically linked to a number of illnesses (see Section 8.1).

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References

  1. Ablashi, D. V, Josephs, S. F., Buchbinder, A., Hellman, K., Nakamura, S., Llana, T., Lusso, P., Kaplan, M., Dahlberg, J., Memon, S., Iman, F., Abalshi, K. L., Markham, R. D., Kramarsky, B., Krueger, G. R. E, Biberfeld, P, Wongstaal, E, Salahuddin, S.Z., And Gallo, R. C., Human B-lymphotropic virus (human herpes virus-6), J. Virol. Methods 21: 2948 (1988).

    Article  Google Scholar 

  2. Ablashi, D. V., Balachandran, N., Josephs, S. E, Hung, C. L., Krueger, G. R. E, Kramarsky, B., Salahuddin, S. Z., And Gallo, R. C., Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates, Virology 184: 545–552 (1991).

    Article  PubMed  CAS  Google Scholar 

  3. Ablashi, D. V., Salahuddin, S. Z., Josephs, S. F., Imam, E, Lusso, P., And Gallo, R. C., Hblv (or Hhv-6) in human cell lines (letter), Nature 329: 207 (1987).

    Article  PubMed  CAS  Google Scholar 

  4. Ablashi, D. V., Agut, H., Bernemann, Z., Campadelli-Fiume, G., Carrigan, D., Ceccerini-Nelli, L, Chandran, B., Chou, S., Collandre, H., Cone, R., Dambaugh, T., Dewhurst, S., DilucA, D., FoA-ToMAsI, L., Fleckenstein, B., Frenkel, N., Gallo, R., Gompels, U., Hall, C., Jones, M., Lawrence, G., Martin, M., Montagnier, L., Neipel, F., Nicholas, J., Pellett, R. (Corresponding Author), Razzaque, A., Torrelli, G., Thompson, B., Salahuddin, S., Wyatt, L., And Yamanishi, K., Human herpesvirus-6 strain groups: A nomenclature, Arch. Virol. 129: 363–366 (1993).

    Article  Google Scholar 

  5. Agut, H., Puzzles concerning the pathogenicity of human herpesvirus 6, N. Engl. J. Mid. 329: 203–204 (1993).

    Article  CAS  Google Scholar 

  6. Agut, H., Huraux, J-M., Collandre, H., And Montagnier, L., Susceptibility of human herpes-virus 6 to acyclovir and ganciclovir, Lancet 2: 626 (1989).

    Article  PubMed  CAS  Google Scholar 

  7. AmbindvR, R. F., Browning, R. J., Lorenzana, I., Leventhal, B. G., Cosenza, H., Mann, R. B., Macmahon, E. M. E., Medina, R., Cardona, V., Grufferman, S., Olshan, A., LE-Vin, A., Petersen, E. A., Blattner, W., And Levine, R H., Epstein-Barr virus and childhood Hodgkin’s disease in Honduras and the United States, Blood 81: 462–467 (1993).

    Google Scholar 

  8. Anagnostopoulos, I., Hummel, M., Korbjuhn, R, Papadaki, T., Anagnostou, D., And Stein, H., Epstein-Barr virus in Kikuchi-Fujimoto disease (letter), Lancet 341: 893 (1993).

    Article  PubMed  CAS  Google Scholar 

  9. Ando, Y., KaiuMoTo, K., Ekuni, Y., And Ichijo, M., Hhv-6 infection during pregnancy and spontaneous abortion (letter), Lancet 1289 (1992).

    Google Scholar 

  10. Asano, Y., Yoshikawa, T., Kajita, Y., Ogura, R., Suga, S., Yazaki, T., Nakashima, T., Yamada, A., And Kurata, T., Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection, Arch. Dis. Child 67: 1484–1485 (1992).

    Article  PubMed  CAS  Google Scholar 

  11. Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., KoNDo, K., And Yamanishi, K., Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection (letter), Lancet 335: 862–863 (1990).

    Article  PubMed  CAS  Google Scholar 

  12. Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., Hata, T., Nagai, T., Kajita, Y., Ozaki, T., And Yoshida, S., Viremia and neutralizing antibody response in infants with exanthem subitum, J. Pediatr. 114: 535–539 (1989).

    Article  PubMed  CAS  Google Scholar 

  13. Aubin, J.-T., Collandre, H., Candotti, D., Ingrand, D., RouzloUX, C., Burgard, M., Richard, S., Huraux, J.-M., And Agut, H., Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction, J. Clin. Microbiol. 29: 367–372 (1991).

    PubMed  CAS  Google Scholar 

  14. Baboonian, C., Venables, P. J. W., Maini, R. N., Kangro, H. O., And Osman, H. K., Antibodies to human herpesvirus-6 in Sjogren’s syndrome, Arthritis Rheum. 33: 1749–1750 (1990).

    Article  PubMed  CAS  Google Scholar 

  15. Barenberg, L. H., And Greenspan, L., Exanthema subitum (roseola infantum), Am. J. Dis. Child. 58: 983–993 (1939).

    Google Scholar 

  16. Berneman, Z. N., Ablashi, D. V., LI, G., Eger-Fletcher, M., Reitz, M. S., JR., Hung, C.-L., Brus, I., Komaroff, A. L., And Gallo, R. C., Human herpesvirus 7 is a T-lymphotropic virus and is related to but significantly different from herpesvirus 6 and human cytomegalovirus, Proc. Natl. Acad. Sci. Usa 89: 10552–10556 (1992).

    Article  PubMed  CAS  Google Scholar 

  17. Berneman, Z. N., Gallo, R. C., Ablashi, D. V., Frenkel, N., Katsafanas, G., Kramarsky, B., And Brus, I., Human herpesvirus 7 (Hhv-7) strain JI independent confirmation of Hhv-7, J. Infect. Dis. 166: 690–691 (1992).

    Article  PubMed  CAS  Google Scholar 

  18. Bertram, G., Dreiner, N., Krueger, G. R. F., Ablashi, D. V., And Salahuddin, S. Z., Serological correlation of Hhv-6 and Ebv infections in infectious mononucleosis, in: Epstein-Barr Virus and Human Disease (D. V. Ablashi, A. Faggioni, And G. R. F. Krueger, Eds.), pp. 361–367, Humana Press, Clifton, NJ, 1989.

    Google Scholar 

  19. Biberfeld, E, Petren, A.-L., Eklund, A., Lindemalm, C., Barkhem, T., Ekman, M., Ablashi, D., And Salahuddin, Z., Human herpesvirus-6 (Hhv-6, Hblv) in sarcoidosis and lymphoproliferative disorders, J. Virol. Methods 21: 49–59 (1988).

    Article  PubMed  CAS  Google Scholar 

  20. Black, J. B., Inoue, N., Kite-Powell, K., Salahuddin, Z., And Pellett, P. E., Frequent isolation of human herpesvirus 7 from saliva, Virus Res. 29 (1): 91–98 (1993).

    Article  PubMed  CAS  Google Scholar 

  21. Breese, B. B., JR., Roseola infantum (exanthem subitum), NY State J. Med. 41: 1854–1859 (1941).

    Google Scholar 

  22. Briggs, M., Fox, J., And Tedder, R. S., Age prevalence of antibody to human herpes virus-6, Lancet 1: 1058–1059 (1988).

    CAS  Google Scholar 

  23. Brown, N. A., Sumaya, C. V., Liu, C.-R., Ench, Y., Kovacs, A., Coronesi, M., And Kaplan, M. H., Fall in human herpesvirus-6 seropositivity with age, Lancet 2: 396 (1988).

    Article  PubMed  CAS  Google Scholar 

  24. Buchwald, D., And Komaroff, A. L., Review of laboratory findings for patients with chronic fatigue syndrome, Rev. Infect. Dis. 13: S12 - S18 (1991).

    Article  PubMed  Google Scholar 

  25. Buchwald, D., Cheney, P. R., Peterson, D. L., Henry, B., Wormsley, S. B., Geiger, A., Ablashi, D. V., Salahuddin, S. Z., Saxinger, C., Biddle, R., Kikinis, R., Jolesz, E A., Folks, T., Balachandran, N., Peter, J. B., Gallo, R. C., And Komaroff, A. L., A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpes-virus type 6 infection, Ann. Inter. Med. 116: 103–113 (1992).

    Article  CAS  Google Scholar 

  26. Buchwald, D., Hooton, T. M., And Ashley, R. L., Prevalence of herpesvirus, human T-lymphotropic virus type I, and treponemal infection in Southeast Asian refugees, J. Med. Virol. 38: 195–199 (1992).

    Article  PubMed  CAS  Google Scholar 

  27. Burns, W. H., And Sanford, G. R., Susceptibility of human herpesvirus 6 to antivirals in vitro, J. Infect. Dis. 162: 634–637 (1990).

    Article  PubMed  CAS  Google Scholar 

  28. Caligiuri, M., Murray, C., Buchwald, D., Levine, H., Cheney, P., Peterson, D., Komaroff, A. L., And Ritz, J., Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome, J. Immunol. 139: 3306–3313 (1987).

    PubMed  CAS  Google Scholar 

  29. Carrigan, D. R., Human herpesvirus-6 and bone marrow transplantation, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. E Krueger, And S. Z. Salahuddin, Eds.), pp. 281–301, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  30. Carrigan, D. R., KNox, K. K., And Tapper, M. C., Suppression of human immunodeficiency virus type I replication by human herpesvirus-6, J. Infect. Dis. 162: 844–851 (1990).

    Article  PubMed  CAS  Google Scholar 

  31. Carrigan, D. R., Drobyski, W. R., Russler, S. K., Tapper, M. A., KNox, K. K., And Asti, R. C., Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation, Lancet 338: 147–149 (1991).

    Article  PubMed  CAS  Google Scholar 

  32. Cermelli, C., Moroni, A., Pietrosemoli, P., Pecorari, M., And Portolani, M., IgG antibodies to human herpesvirus-6 (Hhv-6) in Italian people, Microbiologica 15: 57–63 (1992).

    PubMed  CAS  Google Scholar 

  33. Chandran, B., Tirawatnapong, S., Pfeiffer, B., And Ablashi, D. V., Antigenic relationships among human herpesvirus-6 isolates, J. Med. Virol. 37: 247–254 (1992).

    Article  PubMed  CAS  Google Scholar 

  34. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., KNowLEs, D. M., And MooRE, R S., Identification of herpesvirus-like Dna sequences in Aids-associated Kaposi’s sarcoma, Science 266: 1865 (1994).

    Article  PubMed  CAS  Google Scholar 

  35. Chen, M., Wang, H., Woodworth, C. D., Lusso, R, Berne-Man, Z., Kingman, D., Delgado, G., And Dipaola, J. A., Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma, Am. J. Pathol. 145: 1509–1516 (1994).

    PubMed  CAS  Google Scholar 

  36. Cherry, D., Roseola infantum (exanthem subitum), Textbook of Pediatric Infectious Diseases, 2nd ed. (R. D. Feign And J. D. Cherry, Eds.), pp. 1842–1845, Saunders, Philadelphia, 1987.

    Google Scholar 

  37. Clark, D. A., Alexander, E E., Mckinney, R A., Roberts, B. E., O’Brien, C., Jarrett, R. E, Cartwright, R. A., And Onions, D. E., The seroepidemiology of human herpesvirus-6 (Hhv-6) from a case-control study of leukaemia and lymphoma, Int. J. Cancer 45: 829–833 (1990).

    Article  PubMed  CAS  Google Scholar 

  38. Clark, D. A., Freeland, J. M. L., Mackie, P. L. K., Jarrett, R. F., And Onions, D. E., Prevalence of antibody to human herpesvirus 7 by age, J. Infect. Dis. 168: 251–252 (1993).

    Article  PubMed  CAS  Google Scholar 

  39. Clemens, H. H., Exanthem subitum (roseola infantum); Report of eighty cases, J. Pediatr. 26: 66–67 (1945).

    Article  Google Scholar 

  40. Coyle, R V., Briggs, M., Tedder, R. S., And Fox, J. D., Comparison of three immunoassays for the detection of antiHhv-6, J. Virol. Methods 38: 283–295 (1992).

    Article  PubMed  CAS  Google Scholar 

  41. Cushing, H. B., An epidemic of roseola infantum, Can. Med. Assoc. J. 17: 905–906 (1927).

    PubMed  CAS  Google Scholar 

  42. Declerck, L. S., Bourgeois, N., Krueger, G. R. E, And Stevens, W. J., Human herpesvirus-6 in Sjögren’s syndrome, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4. (D. V. Ablashi, G. R. E, Krueger, And S. Z. Salahuddin, Eds.), pp. 303–315, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  43. Dewhurst, S., Chandran, B., Mcintyre, K., Schnabel, K, And Hall, C. B., Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants, Virology 190: 490–493 (1992).

    Article  PubMed  CAS  Google Scholar 

  44. Dewhurst, S., Mcintyre, K., Schnabel, K., And Hall, C. B., Human herpesvirus 6 (Hhv-6) variant B accounts for the majority of symptomatic primary Hhv-6 infections in a population of U.S. infants, J. Clin. Microbiol. 31 (2): 416–418 (1993).

    PubMed  CAS  Google Scholar 

  45. DilucA, D., Mirandola, P., Secchiero, P., Cermelli, C., Aleotti, A., Bovenzi, P., Portolani, M., And Cassai, E., Characterization of human herpesvirus 6 strains isolated from patients with exanthem subitum with or without cutaneous rash (letter), J. Infect. Dis. 166: 689 (1992).

    Article  Google Scholar 

  46. Downing, R. G., Sewankambo, N., Serwadda, D., Honess, R., Crawford, D., Jarrett, R., And Griffin, B. E., Isolation of human lymphotropic herpesvirus from Uganda (letter), Lancet 2: 390 (1987).

    Article  PubMed  CAS  Google Scholar 

  47. Drobyski, W. R., Dunne, W. M., BuRD, E. M., Knox, K. K., Ash, R. C., Horowitz, M. M., Flomenberg, N., And Carrigan, D. R., Human herpesvirus-6 (Hhv-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for Hhv-6 in vivo, J. Infect. Dis. 167: 735–739 (1993).

    Article  PubMed  CAS  Google Scholar 

  48. Drobyski, W. R., KNox, K. K., Majewski, D., And Carrigan, D. R., Brief report: Fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow transplant recipient, N. Engl. J. Med. 19: 1356–1360 (1994).

    Article  Google Scholar 

  49. Dreyer, Z. A. E., Dowell, B. L., Chen, H., Hawkins, E., And Mcclain, K. L., Infection-associated hemophagocytic syndrome, Am. J. Pediatr. Hematol. Oncol. 13: 476–481 (1991).

    Article  PubMed  CAS  Google Scholar 

  50. Dubedat, S., And Kappagoda, N., Hepatitis due to human herpesvirus-6, Lancet 2: 1463–1464 (1989).

    Article  PubMed  CAS  Google Scholar 

  51. Dunne, W. M., JR., And Demmler, G. J., Serological evidence for congenital transmission of human herpesvirus 6, Lancet 340: 121–122 (1992).

    PubMed  Google Scholar 

  52. Eizuru, Y., Minematu, T., Mwamishima, Y., Kikuchi, M., Yamanishi, K., Takahashi, M., And Kurata, T., Human herpesvirus-6 in lymph nodes, Lancet 1: 40 (1989).

    Article  Google Scholar 

  53. Eizuru, Y., And Minamishima, Y., Evidence for putative immediate early antigens in human herpesvirus 6-infected cells, J. Gen. Virol. 73: 2161–2165 (1992).

    Article  PubMed  CAS  Google Scholar 

  54. Enders, G., Biber, M., Meyer, G., And Helftenbein, E., Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and Hiv, Infection 18: 12–15 (1990).

    Article  PubMed  CAS  Google Scholar 

  55. Evans, A. S., Causation and disease: The Henle-Koch postulates revisited, Yale, J. Biol. Med. 49: 175–195 (1976).

    CAS  Google Scholar 

  56. Fairfax, M. R., Schacker, T., Cone, R. W., Collier, A C, And Corey, L., Human herpesvirus 6 Dna in blood cells of human immunodeficiency virus-infected men: Correlation of high levels with high CD4 cell counts, J. Infect. Dis. 169: 1342–1345 (1994).

    Article  PubMed  CAS  Google Scholar 

  57. Fillet, A. M., Raguin, G., Agut, H., Boisnic, S., Agbogodeau, S., And Robert, C., Evidence of human herpesvirus 6 in Sjögren syndrome and sarcoidosis, Eur. J. Clin. Microbiol. Infect. Dis. 11: 564–566 (1992).

    Article  PubMed  CAS  Google Scholar 

  58. Fo’A-TomAsi, L., Avitabile, E., KE, L., And Campadellifiume, G., Polyvalent and monoclonal antibodies identify major immunogenic proteins specific for human herpesvirus 7-infected cells and have weak cross-reactivity with human herpesvirus 6, J. Gen. Virol. 75: 2719–2727 (1994).

    Article  Google Scholar 

  59. Foucar, E., Rosai, J., And Dorfman, R. F., Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity, Semin. Diagn. Pathol. 7: 19–73 (1990).

    PubMed  CAS  Google Scholar 

  60. Foucar, E., Rosai, J., And Dorfman, R. E, Sinus histiocytosis with massive lymphoadenopathy. An analysis of 14 deaths occurring in a patient registry, Cancer 54: 1834–1840 (1984).

    Article  PubMed  CAS  Google Scholar 

  61. Fox, J., Briggs, M., And Tedder, R. S., Antibody to human herpesvirus 6 in Hiv-1 positive and negative homosexual men, Lancet 2: 396–397 (1988).

    Article  PubMed  CAS  Google Scholar 

  62. Fox, J. D., Briggs, M., Ward, P. A., And Tedder, R., Human herpesvirus 6 in salivary glands, Lancet 336: 590–593 (1990).

    Article  PubMed  CAS  Google Scholar 

  63. Frenkel, N., Schirmer, E. C., Wyatt, L. S., Katsafanas, G., Roffman, E., Danovich, R. M., And June, C. H., Isolation of a new herpesvirus from human CD4+ T cells, Proc. Natl. Acad. Sci. Usa 87: 748–752 (1990).

    Article  PubMed  CAS  Google Scholar 

  64. Frenkel, N., And Wyatt, L. S., Hhv-6 and Hhv-7 as exogenous agents in human lymphocytes, in: Developments in Biological Standardization, Vol. 76 (F. Brown, E. E. Esber, And M. Williams, Eds.), pp. 259–265, Karger, Basal, 1992.

    Google Scholar 

  65. Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., And The International Chronic Fatigue Syndrome Study Group, The chronic fatigue syndrome: A comprehensive approach to its definition and study, Ann. Intern. Med. 121: 953–959 (1994).

    Article  Google Scholar 

  66. Gopal, M. R., Thomson, B. J., Fox, J., Tedder, R. S., And HoNess, R. W., Detection by Pcr of Hhv-6 and Ebv Dna in blood and oropharynx of healthy adults and Hiv seropositives, Lancet 1: 1598–1599 (1990).

    Article  Google Scholar 

  67. Gompels, U. A., Carrigan, D. R., Carss, A. L., And Arno, J., Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin’s lymphoma and bone marrow transplant patients, J. Gen. Virol. 74: 613–622 (1993).

    Article  PubMed  CAS  Google Scholar 

  68. Hagiwara, K., Komura, H., Kishi, E, Kaji, T., And Yoshida, T., Isolation of human herpesvirus-6 from an infant with Kawasaki disease (letter), Eur. J. Pediatr. 151: 867–868 (1992).

    Article  PubMed  CAS  Google Scholar 

  69. Hall, C. B., Long, C. E., Schnabel, K. C., Caserta, M. T., Mcintyre, K. M., CoStanzo, M. A., KNoTT, A., Dewhurst, S., Insel, R. A., And Epstein, L. G., Human herpesvirus-6 infection in children. A prospective study of complications and reactivation, N. Engl. J. Med. 331: 432–438 (1994).

    Article  PubMed  CAS  Google Scholar 

  70. Henle, G., And Henle, W., Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacteriol. 91: 1248–1256 (1966).

    PubMed  CAS  Google Scholar 

  71. Hidaka, Y., Liu, Y., Yamamoto, M., Mori, R., Miyazaki, C., Kusuhara, K., Okada, K., And Ueda, K., Frequent isolation of human herpesvirus 7 from saliva samples, J. Med. Virol. 40: 343–346 (1993).

    Article  PubMed  CAS  Google Scholar 

  72. Hoffmann, A., Kirn, E., Kuerten, A., Sander, C. H., Krueger, G. R. F., And Ablashi, D. V., Active human herpesvirus-6 (Hhv-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus (Sle), In Vivo 5: 265–270 (1991).

    PubMed  CAS  Google Scholar 

  73. Hollingsworth, H. C., Peiper, S. C., Weiss, L. M., Raffeld, M., And Jaffe, E. S., An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease. Lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents, Arch. Pathol. Lab. Med. 118: 134–140 (1994).

    PubMed  CAS  Google Scholar 

  74. Holmes, G. P., Kaplan, J. E., Gantz, N. M., Komaroff, A. L., Schonberger, L. B., Straus, S. E., Jones, J. F., DuBois, R. E., Cunningham-Rundles, C., Pahwa, S., Tosato, G., Zegans, L. S., Purtilo, D. T., Brown, N., Schooley, R. T., And Brus, I., Chronic fatigue syndrome: A working case definition, Ann. Intern. Med. 108: 387–439 (1988).

    Article  PubMed  CAS  Google Scholar 

  75. Holmes, G. P., Kaplan, J. E., Stewart, J. A., Hunt, B., Pinsky, P. E, And Schonberger, L. B., A cluster of patients with a chronic mononucleosis-like syndrome: Is Epstein-Barr virus the cause? J.A.M.A. 257: 2297–2302 (1987).

    Article  PubMed  CAS  Google Scholar 

  76. Horvat, R. T., Wood, C., And Balachandran, N., Transactivation of human immunodeficiency virus promoter by human herpesvirus 6, J. Virol. 63: 970–973 (1988).

    Google Scholar 

  77. Horwitz, C. A., And Beneke, J., Human herpesvirus-6 revisited, Am. J. Clin. Pathol. 99: 533–534 (1993).

    PubMed  CAS  Google Scholar 

  78. Huang, L. M., Kuo, P. E, Lee, C. Y., Chen, J. Y., Liu, M. Y., And Yang, C. S., Detection of human herpesvirus-6 Dna by poly-merase chain reaction in serum or plasma, J. Med. Virol. 38: 7–10 (1992).

    Article  PubMed  CAS  Google Scholar 

  79. Huang, L. M., Lee, C. Y., Lin, K. H., Chuu, W. M., Lee, P. I., Chen, R. L., Chen, J. M., And Lin, D. T., Human herpesvirus-6 associated with fatal haemophagocytic syndrome (letter), Lancet 60–61 (1990).

    Google Scholar 

  80. Irving, W. L., And Cunningham, A. L., Serological diagnosis of infection with human herpesvirus-6, Br. Med. J. 300: 156–159 (1990).

    Article  CAS  Google Scholar 

  81. Iyengar, S., Levine, P. H., Ablashi, D., Neequaye, J., And Pearson, G. R., Seroepidemiological investigations on human herpesvirus 6 (Hhv-6) infections using a newly developed early antigen assay, Int. J. Cancer 49: 551–557 (1991).

    Article  PubMed  CAS  Google Scholar 

  82. James, V., And Freier, A., Roseola infantum: Outbreak in a maternity hospital, Arch. Dis. Child. 23–24:54–58 (1948–1949).

    Google Scholar 

  83. Jarrett, R. F., Gledhill, S., Qureshi, E, Crae, S. H., Madhok, R., Brown, I., Evans, I., Krajewski, A., O’Brien, C. J., Cartwright, R. A., Venables, P., And Onions, D. E., Identification of human herpesvirus 6-specific Dna sequences in two patients with non-Hodgkin’s lymphoma, Leukemia 2: 496–502 (1988).

    PubMed  CAS  Google Scholar 

  84. Josephs, S. F., Buchbinder, A., Streicher, H. Z., Ablashi, D. V., Salahuddin, S. Z., Guo, H. G., Wong-Staal, F., Cossman, J., Raffeld, M., Sunden, J., Levine, P., Biggar, R., Krueger, G. R. F., Fox, R. I., And Gallo, R. C., Detection of human B-Iymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients, Leukemia 2: 132–135 (1988).

    PubMed  CAS  Google Scholar 

  85. Jureti, M., Exanthema subitum: A review of 243 cases, Helv. Paediatr. Acta 18: 80–95 (1963).

    Google Scholar 

  86. Kakimoto, K., Ando, Y., Moriyama, I., And Ichuo, M., The significance of determination of human herpesvirus-6 (Hhv-6) antibody during pregnancy, Nippon Sanka Fujinka Gakkai Zasshi 44: 1571–1577 (1992).

    PubMed  CAS  Google Scholar 

  87. Kawa-HA, K., Tanaka, K., Inoue, M., Sakata, N., Okada, S., Kurata, T., MuKai, T., And Yamanishi, K., Isolation of human herpesvirus 7 from a child with symptoms mimicking chronic Epstein-Barr virus infection, Br. J. Haematol. 84: 545–548 (1993).

    Article  Google Scholar 

  88. Keim, D. E., Keller, E. W., And Hirsch, M. S., Mucocutaneous lymph-node syndrome and parainfluenza 2 virus infection, Lancet 2: 303 (1977).

    Article  PubMed  CAS  Google Scholar 

  89. Kempe, C. H., Shaw, 8. B., Jackson, J. It., And Silver, H. K., Studies on the etiology of exanthema subitum (roseola infantum), J. Pediatr. 37: 561–568 (1950).

    Article  PubMed  CAS  Google Scholar 

  90. Kikuchi, M., Sumiyoshi, Y., And Minamishima, Y., Kukuchi’s disease (histiocytic necrotizing lymphadenitis), in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. E. Krueger, And S. Z. Salahuddin, Eds.), pp. 175–183, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  91. KuxuTA, H., Lu, H., And Matsumoto, S., Susceptibility of human herpesvirus 6 to acyclovir (letter), Lancet 2: 861 (1989).

    Google Scholar 

  92. Klimas, N. G., Salvato, E R., Morgan, R., And Fletcher, M. A., Immunologic abnormalities in chronic fatigue syndrome, J. Clin. Microbiol. 28: 1403–1410 (1990).

    PubMed  CAS  Google Scholar 

  93. Knowles, W., And Gardner, S., High prevalence of antibody to human herpesvirus 6 and seroconversion with rash in two infants, Lancet 2: 912–913 (1988).

    Article  PubMed  CAS  Google Scholar 

  94. KNox, K. K., And Carrigan, D. R., In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection, J. Infect. Dis. 165:925–929 (1992).

    Google Scholar 

  95. KNox, K. K., And Carrigan, D. R., Disseminated active Hhv-6 infections in patients with Aids, Lancet 343: 577–578 (1994).

    Article  PubMed  CAS  Google Scholar 

  96. Kondo, K., Nagafuji, H., Hata, A., Tomomori, C., And Yamanishi, K., Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions, J. Infect. Dis. 167: 1197–1200 (1993).

    Article  PubMed  CAS  Google Scholar 

  97. Krueger, G. R. È, Manak, M., Bourgeois, N., Ablashi, D. V., Salahuddin, S. Z., Josephs, S. F., Buchbinder, A., Gallo, R. C., Berthold, F., And Tesch, H.; Persistent active herpes virus infection associated with atypical polyclonal lymphoproliferation (Apl) and malignant lymphoma, Anticancer Res. 9: 1457–1476 (1989).

    PubMed  CAS  Google Scholar 

  98. Kurata, T., Iwasaki, T., Sata, T., Wakabayashi, T., Yamaguchi, K., Okuno, T., Yamanishi, K., And Takei, I., Viral pathology of human herpesvirus 6 infection, in: Immunobiology and Prophylaxis of Human Herpesvirus Infections (C. Lopez, R. Mori, B. Roizman, And R. J. Whitley, Eds.), pp. 39–47

    Google Scholar 

  99. Plenum Press, New York. Lawrence, G. L., Chee, M., Craxton, M. A., Gompels, U. A., Honess, R: W., And Barrell, B. G., Human herpesvirus 6 is closely related to human cytomegalovirus, J. Vrml. 64: 287–299 (1990).

    Google Scholar 

  100. Leach, C. T., Newton, E. R., Mcparlin, S., And Jenson, H. B., Human herpesvirus 6 infection of the female genital tract, J. Infect. Dis. 169: 1281–1283 (1994).

    Article  PubMed  CAS  Google Scholar 

  101. a. Levine, P. H., And Ablashi, D. V., The new herpesviruses: Hhv-7 and Hhv-8 (KS-virus), Infections in Medicine (in press).

    Google Scholar 

  102. Levine, P. H., Ablashi, D. V., Saxinger, W. C., And Connelly, R. R., Antibodies to human herpesvirus-6 in patients with acute lymphocytic leukemia, Leukemia 6: 1229–1231 (1992).

    PubMed  CAS  Google Scholar 

  103. Levine, P. H., Ebbesen, E, Ablashi, D. V., Saxinger, W. C., NoRdentofr, A., And Connelly, R. R., Antibodies to human herpes virus type 6 and clinicallcourse in patients with Hodgkin’s disease, Int. J. Cancer 51: 53–57 (1992).

    Article  PubMed  CAS  Google Scholar 

  104. Levine, P. H., Jacobson, S., Pocinki, A. G., Cheney, P., Peterson, D., Connelly, R. R., Weil, R., Robinson, S. M., Ablashi, D. V., Salahuddin, S. Z., Pearson, G. R., And Hoover, R., Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome, Arch. Intern. Med. 152: 1611–1616 (1992).

    Article  PubMed  CAS  Google Scholar 

  105. Levine, P. H., Jahan, N., Murari, P., Mank, M., And Jaffe, E. S., Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease, J. Infect. Dis. 166: 291–295 (1992).

    Article  PubMed  CAS  Google Scholar 

  106. Levine, P. H., Jarrett, R., And Clark, D. A., The epidemiology of human herpesvirus-6, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 9–23, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  107. Levine, P. H., Krueger, G. R. F., Kaplan, M., Bell, D., Dubois, R.E., Huang, A., Quinlan, A., Buchwald, D., AR-Chard, L., Gupta, S., Jones, J., Straus, S., And Tosato, G., The postinfectious chronic fatigue syndrome, in: Epstein-Barr Virus and Human Disease (D. V. Ablashi, A. T. HuAng, J. S. Pagano, ET AL., Eds.), pp. 405–438, Humana Press, Clifton, NJ, 1989.

    Google Scholar 

  108. Levine, P. H., Neequaye, J., Yadav, M., And Connelly, R., Geographic/ethnic differences. in human herpesvirus-6 antibody patterns, Microbiol. Immunol. 36: 169–172 (1992).

    PubMed  CAS  Google Scholar 

  109. Levy, J. A., Ferro, F., Greenspan, D., And LennerrE, E. T., Frequent isolation of Hhv-6 from saliva and high seroprevalence of the virus in the population, Lancet 335: 1047–1050 (1990).

    Article  PubMed  CAS  Google Scholar 

  110. Levy, J., Landay, A., And Lennette, E., Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture, J. Clin. Microbiol. 28: 2362–2364 (1990).

    PubMed  CAS  Google Scholar 

  111. Lopez, C., Pellett, P., Stewart, J., Goldsmith, C., Sander-Lin, K., Black, J., Warfield, D., And Feorino, P., Characteristics of human herpesvirus-6 (letter), J. Infect. Dis. 157: 1271–1273 (1988).

    Google Scholar 

  112. LuPpi, M., Marasca, R., Barozzi, E, Artusi, T., And Torelli, G., Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma, Leuk. Res. 17: 1003–1111 (1993).

    Article  Google Scholar 

  113. Lusso, P., Ablashi, D. V., And Luka, J., Interactions between Hhv-6 and other viruses, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 121–133, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  114. Lusso, P., Malnati, M. S., Garzino-Demo, A., Crowley, R. W., Long, E. O., And Gallo, R. C., Infection of natural killer cells by human herpesvirus-6, Nature 362: 458–462 (1993).

    Article  PubMed  CAS  Google Scholar 

  115. Lusso, P., Markham, P. D., Tschachler, E., Veronese, F. D. M., Salahuddin, S. Z., Ablashi, D. V., Pahwa, S., Krohn, K., And Gallo, R. C., In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6), J. Exp. Med. 167:1659–1670 (1988).

    Google Scholar 

  116. Maeda, A., Sata, T., Enzan, H., Tanaka, K., Wakiguchi, H., Kurashige, T., Yamanishi, K., And Kurata, T., The evidence of human herpesvirus 6 infection in the lymph nodes of Hodgkin’s disease, Virchows. Arch. A Pathol. Anat. Histopathol. 423 (1): 71–75 (1993).

    Article  PubMed  CAS  Google Scholar 

  117. Merelli, E., Sola, P., Faglioni, P., Poggi, M., Montorsi, M., And Torelli, G., Newest human herpesvirus (Hhv-6) in the Guillain-Barré syndrome and other neurological diseases, Acta Neural. Scand. 85: 334–336 (1992).

    Article  CAS  Google Scholar 

  118. Merlino, C., Sinesi, F., Messina, M., Giacchino, F., And Negro Ponzi, A., Infection by human herpesvirus type 6 (Hhv-6) and renal transplantation, Minerva Urol. Nefrol. 44: 157–153 (1992).

    Google Scholar 

  119. Nakagami, T., Taji, S., Takahashi, M., And Yamanishi, K., Antiviral activity of a bile pigment, biliverdin, against human herpesvirus 6 (Hhv-6) in vitro, Microbiol. Immunol. 36: 381–390 (1992).

    PubMed  CAS  Google Scholar 

  120. Niederman, J. C., Lin, C.-R., Kaplan, M. H., And Brown, N. A., Clinical and serological features of human herpesvirus-6 infection in three adults, Lancet 2: 817–819 (1988).

    Article  PubMed  CAS  Google Scholar 

  121. Hishimura, K., And Igarashi, M., Thrombotic thrombocytopenic purpura associated with exanthem subitum, Pediatrics 60: 260 (1972).

    Google Scholar 

  122. Okano, M., Luka, J., Thiele, G. M., Sakiyama, Y., Matsumoto, S., And Purtilo, D. T., Human herpesvirus-6 infection and Kawasaki disease, J. Clin. Microbiol. 27: 2379–2380 (1989).

    PubMed  CAS  Google Scholar 

  123. Okuno, T., Takahashi, K., Balachandra, K., Shiraki, K., Yamanishi, K., Takahashi, M., And Baba, K., Seroepidemiology of human herpesvirus 6 in normal children and adults, J. Clin. Microbiol. 27: 651–653 (1989).

    PubMed  CAS  Google Scholar 

  124. Pallesen, G., Hamilton-Dutoit, S. J., Rowe, M., And Young, L. S., Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin’s disease, Lancet 337: 320–322 (1991).

    Article  PubMed  CAS  Google Scholar 

  125. Pietroboni, G. R., Harnett, G. B., Bucens, M. R., And Honess, R. W., Isolation of human herpes-virus-6 from saliva, Lancet 1: 1059 (1988).

    Article  PubMed  CAS  Google Scholar 

  126. Pietroboni, G. R., Harnett, G. B., Farr, T. J., And Bucens, M. R., Human herpesvirus type 6 (Hhv-6) and its in vitro effect on human immunodeficiency virus (Hiv), J. Clin. Pathol. 41: 13101312 (1988).

    Google Scholar 

  127. Porlotani, M., Cermelli, C., Moroni, A., Bertolani, M. E, DI Luca, D., Cassai, E., And Sabbatini, A. M., Human herpesvirus-6 infections in infants admitted to hospital, J. Med. Virol. 39: 146–151 (1993).

    Article  Google Scholar 

  128. Prezioso, P. J., Cangiarella, J., Lee, M., Nuovo, G. J., BoRkowsky, W., Orlow, S. J., And Greco, M. A., Fatal disseminated infection with human herpesvirus-6, J. Pediatr. 120: 921923 (1992).

    Google Scholar 

  129. Prussia, P. R., Mansoor, G. A., Edwards, C., And Jordan, O., Haemophagocytic syndrome, West Indian Med. J. 40: 188–192 (1991).

    PubMed  CAS  Google Scholar 

  130. Pruksananonda, P., Hall, C. B., Insel, R. A., Mcintyre, K., Pellett, P. E., Long, C. E., Schnabel, K. C., Pincus, P. H., Stamey, F. R., Dambaugh, T. R., And Stewart, J. A., Primary human herpesvirus 6 infection in young children, N. Engl. J. Med. 326: 1445–1450 (1992).

    Article  PubMed  CAS  Google Scholar 

  131. Qavi, H. B., Green, M. T., Segall, G. K., Lewis, D. E., And Hollinger, E. B., Frequency of dual infections of corneas with Hiv-1 and Hhv-6, Curr. Eye Res. 11: 315–323 (1992).

    Article  PubMed  CAS  Google Scholar 

  132. Qavi, H. B., Green, M. T., And Segall, G. K., Hiv-1 and Hhv-6 infections of human retina and cornea, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.)„ pp. 263–280, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  133. Ranger, S., Patillaud, S., Denis, F., Himmich, A., Sangare, A., M’BouP, S., Ztoua-N’Gaporo, A., Prince-David, M., Chout, R., Cevallos, R., And Agut, H., Seroepidemiology of human herpesvirus-6 in pregnant women from different parts of the world, J. Med. Virol. 34: 194–198 (1991).

    Article  PubMed  CAS  Google Scholar 

  134. Reiner, A. P., And Spivak, J. L., Hematophagic histiocytosis. A report of 23 new patients and a review of the literature, Medicine 67: 369–388 (1988).

    Article  PubMed  CAS  Google Scholar 

  135. Reux, I., Fillet, A. M., Agut, H., Katlama, C., Hauw, J. J., And Lehoang, P., In situ detection of human herpesvirus 6 in retinitis associated with acquired immunodeficiency syndrome (letter), Am. J. Ophthalmol. 114:375–377 (1992).

    Google Scholar 

  136. Risdall, R. J., McKenna, R. W., Nesbit, M. E., Krivit, W., Balfour, H. H., Simmons, R. L., And Brunning, R. D., Virusassociated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis, Cancer 44: 993–1002 (1979).

    Article  PubMed  CAS  Google Scholar 

  137. Russler, S. K., Tapper, M. A., And Carrigan, D. R., Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir, Lancet 2: 382 (1989).

    Article  PubMed  CAS  Google Scholar 

  138. Salahuddin, S. Z., The discovery of human herpesvirus type 6, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 3–8, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  139. Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B., And Gallo, R. C., Isolation of a new virus, Hblv, in patients with lymphoproliferative disorders, Science 234: 596–601 (1986).

    Article  PubMed  CAS  Google Scholar 

  140. Sato, T., Indue, T., Kajiwara, M., Miyazaki, C., Kusunoki, K., And Uedo, K., Acute encephalopathy following exanthem subitum caused by human herpesvirus-6, Kansenshogaku Zasshi 66: 551–554 (1992).

    PubMed  CAS  Google Scholar 

  141. Saranath, D., Mukhopadhyaya, R., Rao, R. S., Fakih, A. R., Naik, S. J., And Gangal, S. G., Cell-mediated immune status in patients with squamous cell carcinoma of the oral cavity, Cancer 56: 1062–1070 (1985).

    Article  PubMed  CAS  Google Scholar 

  142. Saxinger, C., Polesky, H., Eby, N., Grufferman, S., Murphy, R., Tegtmeir, G., Parekh, V., Memon, S., And Hung, C., Antibody reactivity with Hblv (Hhv-6) in U.S. populations, J. Virol. Methods 21: 199–208 (1988).

    Article  PubMed  CAS  Google Scholar 

  143. Schirmer, E. C., Wyatt, L. S., Yamanishi, K., Rodriguez, W. J., And Frenkel, N., Differentiation between two distinct classes of viruses now classified as human herpesvirus 6, Proc. Natl. Acad. Sci. Usa 88: 5922–5926 (1991).

    Article  PubMed  CAS  Google Scholar 

  144. Scott, D. A., And Constantine, N. T., Human herpesvirus type 6 and Hiv infection in Africa, Aids 11: 1161–1162 (1990).

    Article  Google Scholar 

  145. Shanavas, K. R., Kala, V., Vasudevan, D. M., Vijayakumar, T., And Yadav, M., Anti-Hhv-6 antibodies in normal population and in cancer patients in India, J. Exp. Pathol. 6: 95–105 (1992).

    PubMed  CAS  Google Scholar 

  146. Shen, Y. Y., Huang, A. M., Jahan, N., Manak, M., Jaffe, E. S., And Levine, P. H., In situ hybridization detection of human herpesvirus-6 in biopsy specimens from Chinese patients with non-Hodgkin’s lymphoma, Arch. Pathol. Lab. Med. 117:502–506 (1993).

    Google Scholar 

  147. Shibata, D., And Weiss, L. M., Epstein-Barr virus-associated gastric adenocarcinoma, Am. J. Pathol. 140: 769–774 (1992).

    PubMed  CAS  Google Scholar 

  148. Shiraki, K., Okuno, T., Yamanishi, K., And Takahashi, M., Phosphonoacetic acid inhibits replication of human herpesvirus-6, Antiviral Res. 12: 311–318 (1989).

    Article  PubMed  CAS  Google Scholar 

  149. Simmons, A., Demmrich, Y., LA Vista, A., And Smith, K., Replication of human herpesvirus 6 in epithelial cells in vitro, J. Infect. Dis. 166: 202–205 (1992).

    Article  PubMed  CAS  Google Scholar 

  150. Sobue, R., Miyazaki, H., Okamoto, M., Hirano, M., Yoshikawa, T., Suga, S., And Asano, Y., Fulminant hepatitis in primary human herpesvirus-6 infection, N. Engl. J. Med. 324: 1290 (1991).

    Article  PubMed  CAS  Google Scholar 

  151. Spira, T. J., Bozeman, L. H., Sanderlin, K. C., Warfield, D. T., Feorino, P. M., Holman, R. C., Kaplan, J. E., Fishbein, D. B., And Lopez, C, Lack of correlation between human herpesvirus-6 infection and the course of human immunodeficiency virus infection, J. Infect. Dis. 161: 567–570 (1990).

    Article  PubMed  CAS  Google Scholar 

  152. Steeper, T. A., Horwitz, C. A., Ablashi, D. V., Salahuddin, S. Z., Saxinger, C., Saltzman, R., And Schwartz, B., The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (Hhv-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirus, Am. J. Clin. Pathol. 93: 776–783 (1990).

    PubMed  CAS  Google Scholar 

  153. Stevens, J. G., Human herpesviruses: A consideration of the latent state, Microbiol. Rev. 53: 318–332 (1989).

    CAS  Google Scholar 

  154. Straus, S. E., Fritz, S., Dale, J. K., Gould, B., And Strober, W., Lymphocyte phenotype and function in the chronic fatigue syndrome, J. Clin. Immunol. 13: 30–40 (1993).

    Article  PubMed  CAS  Google Scholar 

  155. Streicher, H. Z. Hung, C. L., Ablashi, D. V., Hellman, K., Saxinger, C., Fullen, J., And Salahuddin, S. Z., In vitro inhibition of human herpesvirus-6 by phosphonoformate, J. Virol. Methods 21:301–304 (1988).

    Google Scholar 

  156. Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Kobayashi, I., And Yazaki, T., Human herpesvirus-6 infection (exanthem subitum) without rash, Pediatrics 83: 1003–1006 (1989).

    PubMed  CAS  Google Scholar 

  157. Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Kobayashi, I., And Yazaki, T., Activation of human herpesvirus-6 in children with acute measles, J. Med. Virol. 38: 278–282 (1992).

    Article  PubMed  CAS  Google Scholar 

  158. Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Yazaki, T., Fukuda, M., Kojima, S., Matsuyama, T., Ono, Y., And Oshima, S., IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation, Microbiol. Immunol. 36: 495–506 (1992).

    PubMed  CAS  Google Scholar 

  159. Sumiyoshi, Y., Kikuchi, M., Ohshima, K., Yoneda, S., KoBari, S., Takeshita, M., Eizura, Y., And Minamishima, Y., Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi’s disease) and other forms of lymphadenitis, Am. J. Clin. Pathol. 99: 609–614 (1993).

    PubMed  CAS  Google Scholar 

  160. Tagawa, S., Mizuki, M., Ono’, U., Nakamura, Y., Nozima, J., Yoshida, H., Kondo, K., Mukai, T., Yamanishi, K., And Kitani,T., Transformation of large granular lymphocytic leukemia during the course of a reactivated human herpesvirus-6 infection, Leukemia 6: 465–469 (1992).

    PubMed  CAS  Google Scholar 

  161. Tajiri, H., Nose, O., Baba, K., And Okada, S., Human herpes virus-6 infection with liver injury in neonatal hepatitis, Lancet 335: 863 (1990).

    CAS  Google Scholar 

  162. Takahashi, K., Sonoda, S., Kawakami, K., Miyata, K., OK’, T., Nagata, T., Okuno, T., And Yamanishi, K., Human herpesvirus-6 and exanthem subitum, Lancet 1: 1463 (1988).

    Article  PubMed  CAS  Google Scholar 

  163. Takikawa, T., Hayashibara, H., Harada, Y., And Shiraki, K., Liver dysfunction anaemia and granulocytopenia after exanthema subitum (letter), Lancet 340: 1288–1289 (1992).

    Article  PubMed  CAS  Google Scholar 

  164. Tanaka, K., Kondo, T., Torigoe, S., Okada, S., Mukai, T., And Yamanishi, K., Human herpesvirus 7: Another casual agent for roseola (exanthem subitum), J. Pediatr. 125: 1–5 (1994).

    Article  PubMed  CAS  Google Scholar 

  165. Torelli, G, Marasca, R., Luppi, M., Sellers, L., Ferrari, S., Narni, F., Mariano, M. T., Federico, M., Ceccherini-Neilli, L., Bondinelli, M, Montagnani, G., Montorsi, M., And Artusi, T., Human herpesvirus-6 in human lymphomas: Identification of specific sequences in Hodgkin’s lymphomas by polymerase chain reaction, Blood 77: 2251–2258 (1991).

    PubMed  CAS  Google Scholar 

  166. Torelli, G., Marasca, R., Montorsi, M., Luppi, M., Barozzi, P, Ceccherini, L., Batons, G., Bendinelli, M., And Muyom Bano, A., Human herpesvirus 6 in non-Aids related Hodgkin’s and non-Hodgkin’s lymphomas, Leukemia 6 (Suppl. 3): 46S - 48S (1992).

    PubMed  Google Scholar 

  167. Torigoe, S., Kumamoto, T., Koide, W., Taya, K., And Yamanishi, K., Clinical manifestations associated with human herpesvirus 7 infection, Arch. Dis. Child. (England) 72 (6): 518–519 (1995).

    CAS  Google Scholar 

  168. Viza, D., Aranda-Anzaldo, A., Ablashi, D., And Kramarsky, B., Hhv-6 inhibition by two polar compounds, Antiviral Res. 18:27–38 (1992). (Erratum 19: 179, 1992 )

    CAS  Google Scholar 

  169. Weiss, L. M., Movahed, L. A., Warnke, R. A., And Sklar, J., Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin’s disease, N. Engl. J. Med. 320: 502–506 (1989).

    Article  PubMed  CAS  Google Scholar 

  170. Whitby, D., Hoad, J. G., Tizard, E. J., Dillon, M. J., Weber, J. N., Weiss, R. A., And Schulz, T. F., Isolation of measles virus from a child with Kawasaki disease, Lancet 338: 1215 (1991).

    Article  PubMed  CAS  Google Scholar 

  171. Williams, M. V., Hhv-6: Response to antiviral agents, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 317–335, Elsevier, Amsterdam, 1992.

    Chapter  Google Scholar 

  172. Wyatt, C. S., Balachandran, N., And Frenkel, N., Variations in the replication and antigenic properties of human herpesvirus-6 strains, J. Infect. Dis. 162: 852–857 (1990).

    Article  PubMed  CAS  Google Scholar 

  173. Wyatt, L. S., And Frenkel, N., Human herpesvirus 7 is a constitutive inhabitant of adult human saliva, J. Virol. 66: 3206–3209 (1992).

    PubMed  CAS  Google Scholar 

  174. Wyatt, L. S., Rodriguez, W. J., Balachandran, N., And Frenkel, N., Human herpesvirus 7: Antigenic properties and prevalence in children and adults, J. Virol. 65: 6260–6265 (1991).

    PubMed  CAS  Google Scholar 

  175. Yadav, M., Chandrashekran, A., Vasudevan, D. M., And Ablashi, D. V., Frequent detection of human herpesvirus 6 in oral carcinoma, J. Natl. Cancer Inst. 86: 1792–1794 (1994).

    Article  PubMed  CAS  Google Scholar 

  176. Yamanishi, K., Kondo, K., Mukai, T., Kondo, T., Nagafuji, H., Kato, T., Okuno, T., And Kurata, T., Human herpesvirus 6 (Hhv-6) infection in the central nervous system, Acta Paediatr. Jpn. 34: 337–343 (1992).

    Article  PubMed  CAS  Google Scholar 

  177. Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y., And Kurata, T., Identification of human herpesvirus-6 as a causal agent for exanthem subitum, Lancet 1: 1065–1067 (1988).

    Article  PubMed  CAS  Google Scholar 

  178. Yoshikawa, T., Asano, Y., Kobayashi, I., Nakashima, T., Yazaki, T., Suga, S., Ozaki, T., Wyatt, L. S., And Frenkel, N., Seroepidemiology of human herpesvirus 7 in healthy children and adults in Japan, J. Med. Virol. 41: 319–323 (1993).

    Article  PubMed  CAS  Google Scholar 

  179. Yoshikawa, T., Nakashima, T., Suga, S., Asano, Y., Yazaki, T., KimÜRA, H., Morishima, T., Kondo, K., And Yamanishi, K., Human herpesvirus-6 Dna in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis, Pediatrics 89: 888–890 (1992).

    PubMed  CAS  Google Scholar 

  180. Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Sobue, R., Hirano, M., Fukuda, M., Komma, S., And Matsuyama, T., Human herpesvirus-6 infection in bone marrow transplantation, Blood 78: 1381–1384 (1991).

    PubMed  CAS  Google Scholar 

  181. Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Ono, Y., Fujita, T., Tsuzuki, K., Sugiyama, S., And Oshima, S., A prospective study of human herpesvirus-6 infection in renal transplantation, Transplantation 54: 879–883 (1992).

    Article  PubMed  CAS  Google Scholar 

  182. Zahorsky, J., Roseola infantum, J.A.M.A. 61: 1445–1450 (1913).

    Article  Google Scholar 

  183. Ablashi, D. V., Krueger, G. R. F., And Salahuddin, S. Z. (Eds.), Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4. Elsevier, Amsterdam, 1992.

    Google Scholar 

  184. Leach, C. T., Sumaya, C. V., And Brown, N. A., Human herpesvirus-6 clinical implications of a recently discovered ubiquitous agent, J. Pediatr. 121: 173–181 (1992).

    Article  PubMed  CAS  Google Scholar 

  185. Oren, I., And Sobel, J. D., Human herpesvirus type 6: Review, Clin. Infect. Dis. 14: 741–746 (1992).

    Article  PubMed  CAS  Google Scholar 

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  1. Viral Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Paul H. Levine

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  1. Paul H. Levine
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  1. Department of Epidemiology and Public Health, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alfred S. Evans

  2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294-0008, Birmingham, Alabama, USA

    Richard A. Kaslow

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© 1997 Springer Science+Business Media New York

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Levine, P.H. (1997). Human Herpesvirus-6 and Human Herpesvirus-7. In: Evans, A.S., Kaslow, R.A. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0036-4_15

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  • DOI: https://doi.org/10.1007/978-1-4899-0036-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-44856-0

  • Online ISBN: 978-1-4899-0036-4

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