Abstract
The presence of a thymoma has been recognized as an occurrence beyond statistical probability from the earliest history of myasthenia gravis (MG). After the description by Weigert1 in 1901 of a patient with a thymoma and lymphorrages in his muscles, considered as metastases of the thymoma, an enlargement of the thymus or a thymoma was mentioned in 28% of the first 250 patients with MG, described until 19122. In large recent series of patients with MG, thymomas occurred in 9 to 16%(3a) and in 20 to 34% of series of thymectomies for MG(4–6).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Weigert C. Pathologisch-anatomischer Beitrag zur Erbschen Krankheit (Myasthenia Gravis), Neurologischen Zentralblatt 1901, 20:597–601.
Starr MA. Myasthenia Gravis J Nerv Ment Dis. 1912, 39:721–731.
Oosterhuis HJGH. Myasthenia gravis Churchill Livingstone Edinburgh 1984 a.28; b. 206-207; c. 62-67
Keynes G. Investigations into thymic disease and tumour formation. BR J Surg XLII 1955, 449-462
Mulder DG, Hermann Chr, Keesey J and Edwards H. Thymectomy for Myasthenia Gravis Am J Surg 1983, 146, 61–65.
Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M and Ruffini E. Thymectomy in Myasthenia Gravis: results of 662 cases operated upon in 15 years. Eur J Cardiothorac Surg 1989, 3:504–509.
Monden Y, Uyama T, Taniki T, Hashimoto J, Fujii Y, Nakahara K, Kawashima Y and Masaoka A. The characteristics of thymoma with Myasthenia Gravis: a 28 year experience. J Surg Onc 1988, 38, 151–154.
Levasseur P, Menestrier M, Gaud C, Dartevelle P, Julia P, Rojas-Miranda A, Navajas M, Le Brigand H and Merker M. Thymomas et maladies associées. A propos d’une serie de 255 thymomas opérées, Rev Mal Respir. 1988, 5, 173–178.
Oosterhuis HJGH. Diagnosis and differential diagnosis. In: Myasthenia Gravis. Eds De Baets M and Oosterhuis HJGH. CRC Press Boca Raton 1993, 208-209.
Limburg PC, The TH, Hummel-Tappel E, Oosterhuis HJGH. Anti-acetylcholine receptor antibodies in Myasthenia Gravis. Journal of the Neurological Sciences 1983, 58:357–370.
Masaoka A, Monden Y. Nakahara K, Tamioka T. Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981, 48, 2485–2492.
Osserman KE and Genkins G. Studies in Myasthenia Gravis: a review of a twenty year experience in over 1200 patients. Mt Sinai J Med 1971, 38, 497–537.
Jongste MJL de, Oosterhuis HJGH, Lie KL. Intractable ventricular tachycardia in a patient with giant cell myocarditis, thymoma and Myasthenia Gravis. International Journal of Cardiology 1986, 13, 374–378.
Kuks JBM, Limburg PC, Horst G. Oosterhuis HJGH. 1993 Antibodies to skeletal muscle in Myasthenia Gravis. Part 3 Relation with clinical course and therapy Journal of the Neurological Sciences 1993, 120:168–173.
Palmisani MT, Evoli A, Batocchi AP, Provenzano C, Tonali P. Myasthenia Gravis associated with thymoma: clinical characteristics and long-term outcome. Eur Neurol 1993, 34:78–82.
Oosterhuis HJGH. Myasthenia Gravis. A review: Clinical Neurology and Neurosurgery 1981, 83:105–135.
Monden Y, Kyama T, Kimura S and Tanaki T. 1991 Extrathymic malignancy in patients with Myasthenia Gravis Eur J Cancer 1991, 27: 745–747.
Sommer FE. Exacerbations of Myasthenia Gravis after removal of thymomas. Acta Neurol Scand 1994, 90:56–66.
Husain F, Ryan NJ, Hogan GR, Gonzalez E 1990. Occurrence of invasive thymoma after thymectomy for Myasthenia Gravis: report of a case. Neurology 1990, 40:170–171.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Oosterhuis, H.J.G.H., Kuks, J.B.M. (1997). Myasthenia Gravis with Thymoma. In: Marx, A., Müller-Hermelink, H.K. (eds) Epithelial Tumors of the Thymus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0033-3_36
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0033-3_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0035-7
Online ISBN: 978-1-4899-0033-3
eBook Packages: Springer Book Archive