Abstract
Large T of SV40 is a viral protein involved in the lytic cycle of its natural host, the monkey, but has transforming properties after transfection in some murine and human cell lines. The targeting of this oncogene under the control of tissue-specific promotors in transgenic mice led to the creation of in vivo models of tumors: hepatocarcinomas, lymphomas, neuroendocrine carcinomas, choroid plexus carcinomas, thymic hyperplasia, hypoplasia, thymomas. The oncogenic function of this protein is mainly linked to the sequestration of tumor suppressor gene products, namely p53 and Rb.
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© 1997 Springer Science+Business Media New York
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Molina, T. et al. (1997). Analysis of a Murine Thymic Carcinogenesis Model Induced by the Expression of Large T of SV40. In: Marx, A., Müller-Hermelink, H.K. (eds) Epithelial Tumors of the Thymus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0033-3_21
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DOI: https://doi.org/10.1007/978-1-4899-0033-3_21
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