Abstract
Cells from the dendritic lineage presumably play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection1,2. Langerhans cells (LC), are probably among the first targets for HIV in genital mucosae3,4. Later, in T-cell dependent areas of lymphoid organs, dendritic cells (DC) may also be involved in both virus transmission to CD4+ T cells and the generation of an effective anti-HIV immune response2. There is now agreement that mature DC/LC can take up the virus, reverse transcribe its RNA, cluster to and form syncytia with CD4+ T cells, but the real degree of their permissivity to HIV still remains debated1,5,6. A precise knowledge of the relationships of cells of the DC lineage with HIV is important for understanding AIDS pathogenesis as well as for delineating possible new immunotherapy strategies. Studying their interactions with HIV in different models is therefore warranted.
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Canque, B., Rosenzwajg, M., Camus, S., Yagello, M., Guigon, M., Gluckman, J.C. (1997). In Vitro HIV Infection of Dendritic Cell Precursors. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_66
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_66
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