Abstract
The mechanisms whereby opioid peptides (naturally occuring peptides with opiate — like biological properties) activate processes on their target receptors are still at an early stage of exploration. The aim of receptor research is to purify and isolate receptor glycoproteins or glycolipids in order to further implement the knowledge of the physicochemical aspects involved in the interaction of opioids with their receptor.
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References
Albrecht, O., 1983, The Construction of a Microprocessor-controlled Film Balance for Precision Measurement of Isotherms and Isobars. The Thin Films, 99: 227.
Ashwell, G. and Harford, J., 1982, Carbohydrate-specific Receptors of the Liver. Ann. Rev. Biochem., 51: 531.
Behnam, B. A. and Deber, C.M., 1984, Evidence for a Folded Conformation of Methionine-and Leucine-Enkephalin in a Membrane Environment, J. Biol. Chem., 259: 14.935.
Dickenson, A. H., 1986, Enkephalins: A new Approach to Pain Relief? Nature, 320: 681.
Garcia-Anton, J. M., Sole, N., and Reig, F., 1985, Synthesis of Hydrophobic Enkephalin amides, Int. J. Peptide Protein Res., 26: 591.
Gioannini, T. L., Howard, A., Hiller, J. M. and Simon, E. J., 1984, Affinity Chromatography of Solubilized Opioid Binding Sites using CH-Sepharose modified with a new Naltrexone Derivative, Biochem. Biophys. Res. Commun., 119: 624.
Holaday, J. W., Ruvio, B. A., Robles, L. E., Johnson, C. E., and D’Amato, R. J., 1982, M 154,129, A Putative delta Antagonist reverses Endotoxic Shock Without altering Morphine Analgesia, Life Sci., 31: 2209.
Phillips, M. C. and Chapman, D., 1968, Monolayer Characteristics of Saturated 1,2-diacyl Phosphatidylcholines (lecithins) and Phosphatidylethanolamines of the Air-water Interphase, Biochim. Biophys. Acta, 163: 301.
Rodriguez, R. E., Sole, N., Reig, F., 1986, Analgesic Effects of (D-Met2-Pro5-NH2) — Enkephalin Analogues in Rats, Life Sci., (in press).
Sly, W. S. and Fisher, H. D., 1982, The Phosphomannosyl Recognition System for Intracellular Pools of Receptor and their Roles in Receptor Recycling, J. Cellular Biochim., 18: 67.
Zajac, J. M., and Roques, B. P., 1985, Differences in Binding Properties of mμ and delta Opioid Receptor Subtypes from Rat Brain: Kinetic Analysis and Effects of Ions and Nucleotides, J. of Neurochem., 44: 1605.
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García-Antón, J.M., Reig, F., Valencia, G. (1986). An Approach to Targeted Therapy: Synthesis and Biological Activity of Hydrophobic and Hydrophilic Enkephalin Analogues. In: Davis, S.S., Illum, L., Tomlinson, E. (eds) Delivery Systems for Peptide Drugs. NATO ASI Series, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9960-6_5
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DOI: https://doi.org/10.1007/978-1-4757-9960-6_5
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