Abstract
Poor absorption and metabolic instability usually make the parenteral route of administration the sole practical one for peptide drugs. Restricted permeability of the blood-brain barrier to peptides may constitute another drawback. The availability of suitable delivery systems could possibly extend the field of application of these drugs. On the other hand, technical problems and uncertain forecast of return of investment often actually limit the studies in this area. This was also the case with eledoisin and ceruletide, two naturally occurring peptide drugs developed in our laboratories as a result of a long and continuous collaboration with Prof. V. Erspamer in the field of biologically active peptides of nonmammalian origin.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Agosti, A. and Bertaccini, G., 1969, Nasal absorption of caerulein, The Lancet, March, 15: 580.
Agosti, A., Biasoli, S., and Naranjo, G., 1969, Azione della ceruleina sulla secrezione gastrica umana, Soc. Ital. Biol. Sperim., 45: 778.
Anastasi, A., and Erspamer V., 1963, The isolation and amino acid sequence of eledoisin, the active endecapeptide of the posterior salivary glands of Eledone, Arch. Biochem. Biophys., 101: 56.
Anastasi, A., Erspamer, V., and Endean, R., 1967, Isolation and structure of caerulein, an active decapeptide from the skin of Hyla caerulea, Experientia, 23: 699.
Basso, N., Bagarani, M., Materia, A., Gizzonio, D., De Paolis, C., Praga, C., and Speranza, V., 1985, Effect of caerulein in patients with biliary colic pain, Gastroenterology, 89: 605.
Bernardi, L., Bosisio, G., Chillemi, F., de Caro, G., de Castiglione, R., Erspamer, V., Glässer, A., and Goffredo, O., 1964, Synthetic peptides related to eledoisin, Experientia, 20: 306.
Bernardi, L., de Castiglione, R., Fregnan, G.B., and Glässer, A.H., 1967, An experimental approach to long-lasting hypotensive eledoisin-like peptides, J.Pharm.Pharmac., 19: 95.
Bertaccini, G., 1976, Active polypeptides of nonmammalian origin, Pharmacol.Rev., 28: 127.
Bietti, G.B., de Caro, G., Pecori Giraldi, J., and Romani, E., 1976, Besondere Indikationen für die Anwendung weicher Kontactlinsen als Augentropfenreservoir (Drug release system), Klin.Mbl.Augenheilk., 168: 33.
Castellino, S., de Castiglione, R., Galantino, M., Forino, R., Licci, S., and Perseo, G., Mutagenic contaminants in synthetic peptides obtained by an azide coupling, Manuscript in preparation.
de Castiglione, R., 1983, Exploitation and exploration of ceruletide and eledoisin, two peptides of nonmammalian origin, Biopolymers, 22: 507.
de Castiglione, R., Faoro, F., Piani, S., Perseo, G., Santangelo, F., Arcari, G., di Salle, E., and Rossi, A., 1981, Synthesis and biological activity of dermorphin analogues, Poster presented at the “7th American Peptide Symposium”, Abstract p. 53.
de Castiglione, R., and Rossi, A., 1985, Amphibian skin peptides with analgesic activity, in “8th International Symposium on Medicinal Chemistry, Vol. 1”, R. Dahlbom and J.L.G. Nilsson, eds., Swedish Pharmaceutical Press, Stockholm, pp. 147.
Deschodt-Lanckman, M., Bui, N.D., Noyer, M., and Christophe, J., 1981, Degradation of cholecystokinin-like peptides by a crude rat brain synaptosomal fraction: a study by high pressure liquid chromatography, Regul. Peptides, 2: 15.
di Salle, E., and Ragazzi, P., 1976, Evidenza dellfassorbimento della ceruleina dal tratto gastroenterico mediante valutazione dell’attività colecistochinetica nella cavia, Communication at the “XVIII Congresso Nazionale della Società Italiana di Farmacologia”, Abstract p. 105.
Erspamer, V., and Anastasi, A., 1962, Structure and pharmacological action of eledoisin, the active endecapeptide of the posterior salivary glands of Eledone, Experientia, 18: 58.
Erspamer, V., and Melchiorri, P., 1973, Active polypeptides of the amphibian skin and their synthetic analogues, Pure Appl. Chem., 35: 463.
Erspamer, V., and Melchiorri, P., 1983, Actions of amphibian skin peptides on the central nervous system and the anterior pituitary, in “Neuroendocrine Perspectives, Vol. 2”, E.E. Müller and R.M. Mac Leod, eds., Elsevier Publishers B.V.
Erspamer, V., Melchiorri, P., Falconieri Erspamer, G., Montecucchi, P.C., and de Castiglione, R. 1985, Phyllomedusa skin: huge factory of a variety of active peptides, Peptides, 6: suppl. 3, 7.
Grossi, E., Vertemati, F., Casiraghi, M.A., Petrillo, M., and Bianchi Porro, G., 1980, Action of caerulein on gastric acid secretion. A comparative study between the rectal and i.m. routes, Il Farmaco-Ed.Pr., 35: 504.
Harman, A.J., 1984, Three tachykinins in mammalian brain, TINS, 7: 57.
Holzer-Petsche, U., Schimek, E., Amann, R., and Lembeck, F., 1985, In vivo and in vitro actions of mammalian tachykinins, Naunyn-Schmiedeberg’s Arch.Pharmacol., 330: 130.
Impicciatore, M., Maraini, G., and Bertaccini, G., 1973, Action of eledoisin on human lacrimal secretion in normal and pathological conditions, Naunyn-Schmiedeberg’s Arch. Pharmacol., 279: 127.
Larsson, L.-J., and Rehfeld, J.F., 1977, Evidence for a common evolutionary origin of gastrin and cholecystokinin, Nature, 269: 335.
Orlandini, I., and Agosti, A., 1969, Azione colecistocinetica della ceruleina e sua utilizzazione nella metodica colangio-colecistografica, Soc.Ital.Biol.Sperim., 45: 782.
Owais, W.M., Rosicham, J.L., Ronald, R.C., Kleinhofs, A., and Nilan, R.A., 1983, A mutagenic metabolite synthesized by Salmonella typhimurium grown in the presence of azide is azidoalanine, Mutation Res., 118: 229.
Pap, A., Berger, Z., and Varrò, V., 1981, Trophic effect of cholecystokinin-octapeptide in man. A new way in the treatment of chronic pancreatis?, Digestion, 21: 163.
Sicuteri, F., Franchi, G., and Anselmi, B., 1962, Proprietà farmacologiche e terapeutiche dell’eledoisina nell’uomo, Settimana Med., suppl. 31 dic.:19.
Solomon, T.E., 1983, Structure-activity relationships of cholecystokinin-related peptides, in “2nd Hiroshima Symposium on Gut Peptides and Ulcer”, A. Miyoshi, ed., Biomedical Research Foundation, Tokyo.
Stürmer, E., and Fanchamps, A., 1965, Eledoisin. Chemie, Pharmakologie, klinisch-experimentelle und Vorlaufige therapeutische Erfahrung, Dt.med.Wschr., 90: 1012.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
de Castiglione, R. (1986). Eledoisin and Ceruletide, Two Naturally Occurring Peptide Drugs of Nonmammalian Origin. In: Davis, S.S., Illum, L., Tomlinson, E. (eds) Delivery Systems for Peptide Drugs. NATO ASI Series, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9960-6_29
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9960-6_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9962-0
Online ISBN: 978-1-4757-9960-6
eBook Packages: Springer Book Archive