Abstract
Respiratory rhythm is partly generated by the periodic actions of classical neurotransmitters which act at the synapse level between different types of respiratory neurons. Periodic glutamate-like excitations (Denavit-Saubié et al., 1978) have been described as well as GABA- and glycine-like inhibitions (Champagnat et al., 1982). A new type of neuroactive substance, neuropeptides, are present in the respiratory networks and are involved in the control of the respiratory rhythm. We have been interested in those which are released in the nucleus tractus solitarii (NTS): cholecystokinin, enkephalins, substance P, neurotensin (Morin-Surun et al., 1983, 1984a,b,c, 1986; Hurlé et al., 1985a).
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Bissette, G., Nemeroff, C.B., Loosen, P.T., Prange, A.J., and Lipton, M.A., 1976, Hypothermia and intolerance to cold induced by instracisternal administration of hypothalamic peptide neurotensin, Nature, 262: 607.
Champagnat, J., Denavit-Saubié, M., Moyanova, S., and Rondouin, G., 1982, Involvement of aminoacids in periodic inhibitions of bulbar respiratory neurones, Brain Res., 237: 351.
Champagnat, J., Denavit-Saubié, M., Morin-Surun, M.P., and Roques, B.P., 1984, Interaction of opiates with neurotransmission in the nucleus of the tractus solitarius in rats, J. Physiol. Lond., 354: 152 P.
Denavit-Saubié, M., Champagnat, J., and Zieglgänsberger, W., 1978, Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat, Brain Res., 155: 55.
Elde, R., Hökfelt, T., Johansson, 0., and Terenius, L., 1976, Immunochistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat, Neuroscience, 1: 349.
Euler, C., von, 1986, Brain stem mechanisms for generation and control of breathing pattern, in: “Handbook of Physiology - The Respiratory System, vol.II - Control of Breathing, part one”, A.P. Fishman, N.S. Cherniack, J.G. Widdicombe, and S.R. Geiger, eds., American Physiological Society, Washington, D.C.
Foutz, A.S., Dauthier, C., and Kerdeihue, B., 1983, A-endorphin plasma levels during neuromuscular blockade in unanesthetized cat, Brain Res. 263: 119.
Holaday, J.W., 1985, Endogenous opioids and their receptors, in: “Current Concepts”, Kalamazoo, ed., The Upjohn Company, Michigan. Hughes, J., and Kosterlitz, H.W., 1983, Introduction to opioid peptides, Br. Med. Bull., 39: 1.
Hurlé, M., Morin-Surun, M.P., Foutz, A.S., Boudinot, E., and DenavitSaubié, M., 1985a, Different targets involved in the effect of cholecystokinin on respiration, Eur. J. Pharmacol., 118: 87.
Hurlé, M.A., Mediavilla, A., and Flörez, 1985b, Differential respiratory patterns induced by opioids applied to the ventral medullary and dorsal pontine surfaces of cats, Neuropharmacol., 24: 597.
Kiley, J.P., Eldridge, F.L., and Millhorn, D.E., 1984, The effect of hypothermia on central neural control of respiration, Respir. Physiol., 58: 295.
Larsson, L.I., and Rehfeld, J.F., 1979, Localization and molecular heterogeneity of cholecystokinin in the central and peripheral nervous system, Brain Res., 165: 201.
Ljungdahl, A., Hökfelt, T., Nilssonn, G., and Goldstein, M., 1978, Distribution of substance P-like immunoreactivity in the central nervous system of the rat. I. Cell bodies and nerve terminals, Neuroscience, 3: 861.
Morin, M.P., De Marchi, P., Champagnat, J., Vanderhaeghen, J.J., Rossier, J., and Denavit-Saubié, M., 1983, Inhibitory effect of cholecystokinin octapeptide on neurons in the nucleus tractus solitarius, Brain Res., 265: 333.
Morin-Surun, M.P., Boudinot, E., Gacel, G., Champagnat, J., Roques, B.P., and Denavit-Saubié, M., 1984a, Different effects of mu and delta opiate agonists on respiration, Eur. J. Pharmacol., 98: 235.
Morin-Surun, M.P., Gacel, G., Champagnat, J., Denavit-Saubié, M., and Roques, B.P., 1984b, Pharmacological identification of delta and mu opiate receptors on bulbar respiratory neurons, Eur. J. Pharmacol., 98: 241.
Morin-Surun, M.P., Jordan, D., Champagnat, J., Spyer, K.M. and DenavitSaubié, M., 1984c, Excitatory effects of iontophoretically applied substance P on neurons in the nucleus tractus solitarius of the cat: lack of interaction with opiates and opioids, Brain Res., 307: 388.
Morin-Surun, M.P., Marlot, D., Kessler, J.P., and Denavit-Saubié, M., 1986, The excitation by neurotensin of nucleus tractus solitarius neurons induces apneustic breathing, Brain Res., 384: 106.
Palkovits, M., and Eskay, R.L., 1987, Distribution and possible origin of A-endorphin and ACTH in discrete brainstem nuclei of rats, Neuropeptides, 9: 123.
Pasternak, G.M., 1986, Multiple morphine and enkephalin receptors: biochemical and pharmacological aspects, Ann. N.Y. Acad. Sci., 467: 130
Roques, B.P., 1986, Pharmacology of different classes of cerebral opioid receptors, Annales d’Endocrinologie, 47: 88.
Sales, N., Riche, D., Roques, B.P., and Denavit-Saubié, M., 1985, Localization of mu and delta-opioid receptors in cat respiratory areas: an autoradiographic study, Brain Res., 344: 382.
Sawchenko, P., and Swanson, L.W., 1982, Immunochistochemical identification of neurons in the paraventricular nucleus that project to the medulla or to the spinal cord in the rat, J. Comp. Neurol., 205: 260.
Yamazoe, M., Shiosaka, S., Shibasaki, T., Ling, N., Tateishi, K., Hashimura, E., Hamacka, T., Kimmel, J.R., Matsuo, H., and Tohyama, H., 1985, Distribution of six neuropeptides in the nucleus tractus solitarius of the rat: an immunochistochemical analysis, Neuroscience, 13: 1243.
Zarbin, M.A., Wamsley, J.K., Innis, R.B., and Kuhar, M.J., 1981, Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve, Life Sciences, 9: 697.
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Morin-Surun, MP., Champagnat, J., Foutz, A., Denavit-Saubié, M. (1988). Control of Breathing by Neuropeptides. In: Karczewski, W.A., Grieb, P., Kulesza, J., Bonsignore, G. (eds) Control of Breathing During Sleep and Anesthesia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9850-0_23
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DOI: https://doi.org/10.1007/978-1-4757-9850-0_23
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