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Control of Breathing and Its Modeling Perspective pp 355–358Cite as

Subacute Effects of Denervation on Rat Hemidiaphragm

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Abstract

Phrenic nerve damage, which is frequently the result of cervical trauma or spinal nerve diseases, may cause respiratory muscle failure. Previous studies have shown that the acetylcholine receptors on the surface of skeletal muscles increased after denervation1, and the resting membrane potential changed to depolarization within two days after denervation2. Another study showed that transformation of muscle fibers occurs in experimental hyperthyroidism, i. e., soleus (slow-twitch fiber) changes to fast and plantaris muscles (fast-twitch fiber) changes to slow within 40 days3. However, it is still unclear whether diaphragm muscle, which is a combination of fast and slow twitch muscle fiber, changes to slower or faster after denervation compared to intact diaphragm. Therefore, we examined the subacute effect of denervation on the physiological changes in muscle contractility and fatigability.

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References

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Author information

Authors and Affiliations

  1. First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, 980, Japan

    C. Shindoh, W. Hida, Y. Kikuchi, S. Ebihara & T. Takishima

Authors
  1. C. Shindoh
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  2. W. Hida
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  3. Y. Kikuchi
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  4. S. Ebihara
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  5. T. Takishima
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Editor information

Editors and Affiliations

  1. Chiba University, Chiba, Japan

    Yoshiyuki Honda

  2. Yamagata University, Yonezawa, Japan

    Yoshimi Miyamoto

  3. Tokyo Women’s Medical College, Tokyo, Japan

    Kimio Konno

  4. St. George’s Hospital Medical School, London, UK

    John G. Widdicombe

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© 1992 Springer Science+Business Media New York

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Shindoh, C., Hida, W., Kikuchi, Y., Ebihara, S., Takishima, T. (1992). Subacute Effects of Denervation on Rat Hemidiaphragm. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_63

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  • DOI: https://doi.org/10.1007/978-1-4757-9847-0_63

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9849-4

  • Online ISBN: 978-1-4757-9847-0

  • eBook Packages: Springer Book Archive

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