Abstract
We used compartmental modeling of a pyramidal cell to examine the hypothesis that prepotentials originate in hot spots or localized regions of high sodium and potassium conductances in the dendritic tree. The full range of experimentally observed prepotentials could be reproduced using compartmental models by incorporating hot spots containing fast sodium conductances and delayed rectifier potassium conductances in densities that were high relative to conductance densities estimated in labs where prepotentials were not observed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Amitai, Y, Friedman, A, Connors, BW and Gutnick, MJ (1993) Regenerative activity in apical dendrites of pyramidal cells in neocortex. Cerebral Cortex 3: 26–38.
Connors, BW, Gutnick MJ and Prince DA (1982) Electrophysiological propertes of neocortical neurons in vitro. Journal of Neurophysiology 48: 1302–1320.
Connors BW, and Gutnick MJ (1990) Intrinsic firing patterns of diverse neocortical neurons. Trends Neuroscience 13: 99–104.
Connors BW and Kriegstein AR (1986) Cellular physiology of the turtle visual cortex: distinctive properteis of pyramidal and stellate neurons. Journal of Neuroscience 6: 164–177.
Hirsch JA and Gilbert CD (1991) Synaptic physiology of horizontal connections in the cat’s visual cortex. Journal of Neuroscience 11: 1800–1809.
Millonas MM and Ulinski PS, Dendritic origins and integrative implications of fast prepotential in pyramidal cells from turtle visual cortex (submitted).
Regehr W, Kchoe, J, Ascher P and Armstrong C (1993) Synaptically triggered action potentials in dendrites. Neuron 11: 145–151.
Spencer WA and Kandel ER (1961) Electrophysiology of hippocampal neurons IV. Fast prepotentials. Journal of Neurophysiology 24: 272–285.
Stuart G and Sakmann B (1994) Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature 367: 69–72.
Traub R (1982) Simulation of intrinsic bursting in CA3 hippocampal neurons. Neuroscience 7: 1233–1242.
Turner RW, Meyers DER and Barker JL Localization of tetrodotoxin-sensitive field potentials of CA I pyramidal cells in the rat hippocampus. (1989) Journal of Neurophsyiology 62: 1375.
Turner RW, Meyers DER, Richardson TL and Barker JL (1991) The site for initiation of action potential discharge over the somatodendritic axis of rat chippocampal CA I pyramidal neurons. Journal of Neuroscience 11: 2270–2280.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Millonas, M.M., Ulinski, P.S. (1997). The Dendritic Origins of Fast Prepotentials in Pyramidal Cells. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9800-5_23
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9800-5_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9802-9
Online ISBN: 978-1-4757-9800-5
eBook Packages: Springer Book Archive