Abstract
Many modeling efforts have met skepticism among experimental neuroscientists largely because of a perception that system parameters are selected arbitrarily. In particular, a lack of high resolution data describing the spatial distribution of voltage-gated and/or calcium-dependent channels has rendered compartmental models suspect of representing singular solutions. On the other hand, a robust manifold of solutions may exist in nature and account for the behavioral repertoire of the biological system. We demonstrate the use of Evolutionary Algorithms (EAs) for the robust fitting of nonlinear channel distributions to experimental observations using the model and kinetics of Traub et al (1991). These results represent a successful method for optimizing parameters in high dimensional (> 100) nonlinear systems.
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References
Bhalla, U. S., Bilitch, D. H.. and Bower. J. M. TINS 15 (11), 453–458 (1992).
Elliott, E.M., Malouf, A.T., and Catterall, W.A. J. Neurosci. 15 (10), 6433–6444 (1995).
Forrest, S. Science 261. 872–878 (1993).
Hablitz, J. J. and Johnston, D. Cell. and Molec. Neurobio. 1 (4), 325–334 (1981).
Holland, J. H. Adaptation in Natural and Artificial Systems. (Ann Arbor. The University of Michigan. (1975).
Maletic-Savatic, M., Lenn, N.J., Trimmer, J.S. J. Neurosci. 15(5). 3840 3851 (1995).
Mills, L.R., Niesen, C.E., So, A.P., Carlen. P.L., Spigelman. I., and Jones, O.T, I. Neurosci. 14 (11), 6815–6824 (1994).
Regehr, W. G. and Tank, D. W. J. Neurosci. 12 (11), 4202–4223 (1992).
Spruston, N., Schiller, Y., Stuart, G., Sakmann, B. Science 268, 297–300 (1995).
Traub, R. D., Wong, R. K. S., Miles, R., and Michelson, H. J. Neurophysiol. 66. 635 650 (1991).
Wong, R. K. S. and Prince, D. A. Brain Res. 159, 385–390 (1978).
Wong RKS, Prince DA (1981) J. Neurophysiol. 45: 86–97.
Wong, R. K. S., Prince, D. A. and Basbaum, A. I. Proc. Natl. Acad. Sci. 76 (2). 986–990 (1979).
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© 1997 Springer Science+Business Media New York
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West, R.M.E., Wilcox, G.L. (1997). Robust Parameter Selection for Compartmental Models of Neurons Using Evolutionary Algorithms. In: Bower, J.M. (eds) Computational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9800-5_13
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DOI: https://doi.org/10.1007/978-1-4757-9800-5_13
Publisher Name: Springer, Boston, MA
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