Abstract
We describe Monte Carlo codes that simulate, event by event, the interaction of energetic electrons with a double-stranded DNA molecule and with the condensed water surrounding it. Both direct and indirect effects are treated explicitly. The cross-sectional input necessary in the transport codes was obtained via quantum-mechanical calculations of the dielectric response function, ε(q,ω), of polycytidine. For each inelastic event on DNA we score the energy deposited locally, the position of the event and the moiety that underwent that event. This information provides a detailed picture of the spatial disposition of molecular alterations for DNA exposed to ionizing radiation.
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© 1994 Springer Science+Business Media New York
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Zaider, M., Fung, A., Bardash, M. (1994). Charged-Particle Transport in Biomolecular Media: The Third Generation. In: Varma, M.N., Chatterjee, A. (eds) Computational Approaches in Molecular Radiation Biology. Basic Life Sciences, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9788-6_7
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DOI: https://doi.org/10.1007/978-1-4757-9788-6_7
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