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Chemical Carcinogenesis pp 75–86Cite as

Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity

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Abstract

Reduced glutathione (GSH) is well-known to play a fundamental role in the protection of the organism against toxic, mutagenic and/or carcinogenic agents (see e.g. refs. 1–3 for reviews). Among synthetic aminothiols, acting as analogs and precursors of GSH, N-acetyl-L-cysteine (NAC) is of particular interest, because this molecule is already extensively used in the treatment of chronic respiratory diseases, and is extremely well tolerated in humans4. In addition, NAC is known to possess various antitoxic and antioxidant properties3–5.

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Author information

Authors and Affiliations

  1. Institute of Hygiene and Preventive Medicine, University of Genoa, 16132, Genoa, Italy

    Silvio De Flora, Carmelo F. Cesarone, Carlo Bennicelli, Anna Camoirano, Domizio Serra, Monia Bagnasco, Anna I. Scovassi, Linda Scarabelli & Umberto Bertazzoni

  2. Institute of General Physiology, University of Genoa, 16132, Genoa, Italy

    Carmelo F. Cesarone & Linda Scarabelli

  3. CNR Institute of Biochemical and Evolutionary Genetics, 27100, Pavia, Italy

    Anna I. Scovassi & Umberto Bertazzoni

Authors
  1. Silvio De Flora
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  2. Carmelo F. Cesarone
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  3. Carlo Bennicelli
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  4. Anna Camoirano
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  5. Domizio Serra
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  6. Monia Bagnasco
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  7. Anna I. Scovassi
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  8. Linda Scarabelli
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  9. Umberto Bertazzoni
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Editor information

Editors and Affiliations

  1. University of Sassari, Sassari, Italy

    Francesco Feo  & Renato Garcea  & 

  2. University of Cagliari, Cagliari, Italy

    Paolo Pani  & Amedeo Columbano  & 

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De Flora, S. et al. (1988). Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_8

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  • DOI: https://doi.org/10.1007/978-1-4757-9640-7_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9642-1

  • Online ISBN: 978-1-4757-9640-7

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