Abstract
Dietary lipids are associated with increased risks for certain types of cancer, especially those of the breast and colon. This enhancing effect has been documented in humans by epidemiological studies1,2,3, as well as by studies in experimental animals4,5,6,7,8. Although the association between dietary lipids and carcinogenesis has been known for a long time, the molecular mechanism by which lipids modulate tumor development remains largely unknown.
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References
B. Armstrong and R. Doll, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices, Int. J. Cancer 15:617 (1975).
K. K. Carroll, Lipids and carcinogenesis, J. Environ. Pathol. Toxicol. 3:253 (1980).
P. Correa, Epidemiological correlations between diet and cancer frequency, Cancer Res. 41:3685 (1981).
L. A. Hillyard and S. Abraham, Effect of dietary polyunsaturated fatty acids on growth of mammary adenocarcinomas in mice and rats, Cancer Res. 39:4430 (1979).
K. K. Carroll and M. B. Davidson, The role of lipids in tumorigenesis, in: “Molecular Interrelations of Nutrition and Cancer”, M. S. Arnott, J. Van Eys and Y.-M. Wang, eds., Raven Press, New York (1982).
C. A. Carter, R. J. Milholland, W. Shea and M. M. Ip, Effect of prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat, Cancer Res. 43:3559 (1983).
A. F. Watson and E. Mellanby, Tar cancer in mice. II: The condition of the skin when modified by external treatment or diet, as a factor in influencing the cancerous reaction, Br. J. Exp. Pathol. 11:311 (1930).
A. Tannenbaum, Nutrition and cancer, in: “The Physiopathology of Cancer”, 2nd ed., F. Homburger, ed., Hoeber-Harper, New York (1959).
E. Hietanen, M. Ahotupa, J.-C. Béréziat, V. Bussacchini, A.-M. Camus and H. Bartsch, Elevated lipid peroxidation in rats induded by dietary lipids and N-nitrosodimethylamine and its inhibition by indomethacin monitored via ethane exhalation, Toxicol. Pathol. 15:93 (1987).
W. Lijinsky and M. D. Reuber, Carcinogenesis in rats by nitrosodimethylamine and other nitrosomethylalkylamines at low doses, Cancer Lett. 22:83 (1984).
F. Corongiu, M. Lai and A. Milia, Carbon tetrachloride, bromotrichloromethane and ethanol acute intoxication, Biochem. J. 212:625 (1983).
F. Corongiu, S. Vargiolu, A. Milia, K. Cheeseman and T. Slater, Antioxidants and lipid peroxidation: in vivo studies, Biochem. Pharmacol. 34:397 (1985).
C. Dillard and L. Tappel, Fluorescent damage products of lipid peroxidation, Meth. Enzymol. 105:337 (1984).
R. P. Bird and H. H. Draper, Comparative studies on different methods of malonaldehyde determination, Meth. Enzymol. 105:299 (1984).
J. R. Wright, R. C. Rumbaugh, H. D. Colby and P. R. Miles, The relationship between chemiluminescence and lipid peroxidation in rat hepatic microsomes, Arch. Biochem. Biophys. 193:344 (1979).
E. Cadenas and H. Sies, Low-level chemiluminescence as an indicator of singlet-molecular oxygen in biological systems, Meth. Enzymol. 105:221 (1984).
A. Wendel and E. E. Dumelin, Hydrocarbon exhalation, Meth. Enzymol. 77:10 (1981).
L. Flohe and F. Otting, Superoxide dismutase assays, Meth. Enzymol. 105:93 (1984).
E. Hietanen, C. Malaveille, A.-M. Camus, J.-C. Béréziat, G. Brun, M. Castegnaro, J. Michelon, J. R. Idle and H. Bartsch, Interstrain comparison of hepatic and renal microsomal carcinogen metabolism and liver S9-mediated mutagenicity in DA and Lewis rats phenotyped as poor and extensive metabolizers of debrisoquine, Drug Metab. Dispos. 14:118 (1986).
G. E. Glock and P. McLean, Further studies on the properties and assay of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver, Biochem. J. 55:400 (1953).
W. P. Norred and A. E. Wade, Dietary fatty-acid-induced alterations of hepatic microsomal drug metabolism, Biochem. Pharmacol. 238:292 (1972).
P. A. Cerutti, Prooxidant states and tumor promotion, Science 227:375 (1985).
M. Ahotupa, J.-C. Béréziat, V. Bussacchini-Griot, A.-M. Camus and H. Bartsch, Lipid peroxidation induced by N-nitrosodimethylamine (NDMA) in rats in vivo and in isolated hepatocytes, Free Rad. Res. Comms. 3:285 (1987).
M. Ahotupa, V. Bussacchini-Griot, J.-C. Béréziat, A.-M. Camus and H. Bartsch, Rapid oxidative stress induced by N-nitrosamines, Biochem. Biophys. Res. Commun. 146:1047 (1987).
J. A. Miller, B. E. Kline, H. P. Rush and C. A. Baumann, The effect of certain lipids on the carcinogenicity of p-dimethylaminoazobenzene, Cancer Res. 4:756 (1944).
K. K. Carroll and H. T. Khor, Effects of level and type of dietary fat on incidence of mammary tumors induced in female Sprague-Dawley rats by 7, 12-dimethylbenz(a)anthracene, Lipids 6:415 (1971).
A. G. Hildebrandt, C. Bergs, G. Heinemeyer, E. Schiede, J. Roots, P. Abbas-Ali and A. Schmoldt, Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone, Adv. Exp. Med. Biol. 136A:179 (1982).
W. E. M. Lands, R. J. Kulmacz and P. J. Marshall, Lipid peroxide actions in the regulation of prostaglandin biosynthesis, in: “Free Radicals in Biology”, vol. VI, W. A. Pryor, ed., Academic Press, New York (1984).
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Bartsch, H., Hietanen, E., Ahotupa, M., Camus, AM., Béréziat, JC. (1988). Modulation by Polyunsaturated Lipid Diets of Nitrosamine-Induced Cancers in Rats: Effects on Prooxidant State and Drug Metabolism. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_65
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DOI: https://doi.org/10.1007/978-1-4757-9640-7_65
Publisher Name: Springer, Boston, MA
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