Abstract
In the last years we have been able to establish CD26 as an operational marker for a human Thl -like reaction in various granulomatous diseases. Recently, CD30 was described as a marker for a Th2-type reaction, where CD30 is preferentially expressed and its soluble form released by human T cell clones producing Th2-type cytokines. To evaluate the possibility of CD30 as an eventual operational marker for a human Th2-like reaction in vivo, we performed immunohistological stainings on frozen sections of skin biopsies from patients with lepromatous and tuberculoid leprosy. A maximum of three to four CD30-positive cells was found per section, and there was no difference in the accumulation of CD30-positive cells between the tuberculoid and the lepromatous form of leprosy. With respect to CD26-positive cells, a high number was found in tuberculoid leprosy in contrast to a greatly reduced expression of CD26 in lepromatous leprosy. We conclude that, while CD26 was confirmed as an operational marker for a Thl-like reaction in leprosy, CD30 does not represent an operational Th2 marker in this disease.
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© 1997 Springer Science+Business Media New York
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Seitzer, U. et al. (1997). Comparative Study of CD26 as a Th1-Like and CD30 as a Potential Th2-Like Operational Marker in Leprosy. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_28
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DOI: https://doi.org/10.1007/978-1-4757-9613-1_28
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