Abstract
Cell surface peptidases are involved in degradative processes of various peptides, in cell-cell communcation, in lymphocyte activation and in cell growth1,2,3,4. Aminopeptidase N (APN, CD 13), a ubiquitously occurring surface molecule of many tissues, among them human liver, kidneys, intestine, placenta, bone marrow or brain microvessels, acts with a relatively broad substrate specifity on peptides with N-terminal neutral amino acids 5. Within the haematopoietic system CD13 is localized on monocytes, granulocytes and activated T lymphocytes5,6,7,8.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brownlees, J., Williams, C.H. (1993) Peptidases. peptides, and the mammalian blood-brain barrier. J. Neurochem. 60, 793–803
Kohno, H., Kanno, T. (1985) Properties and activities of aminopeptidases in normal and mitogen stimulated human lymphocytes. J.Biochem. 226, 59–65
Kohno, H., Kanno, T. (1985) Intracellular localization and properties of aminopeptidases in human peripheral blood lymphocytes. Int. J. Biochem. 17, 1143–1148
Taylor, A. (1993) Aminopeptidases: towards a mechanism of action. TIBS 18, 167–172
Sanderink, G.-J., Artur,Y., Siest, G. (1988) Human aminopeptidase: A review of the literature. J. Clin Chem. Biochem. 26. 795–807
Riemann, D., Göhring. B., Langner, J. (1994) Expression of aminopeptidase N/CD13 in tumor-infiltrating lymphocytes from human renal cell carcinoma. Immunol. Lett. 42, 19–23
Razak, K., Newland, A.C. (1992) The significance of aminopeptidase and haematopoetic cell differentation. Blood Rev. 6, 243–250
Look, A.T. (1989) Human myeloid plasma membrane glycoprotein CD13 (gp 150) is identical to aminopeptidase N. J.Clin.lnvest. 83, 1299–1307
Mattern, T., Ansorge, S., Flad, H-D., Ulmer, A. (1993) Anti-CD26 monoclonal antibodies can reversibly arrest human T lymphocytes in the late Gi phase of the cell cycle. Immunbiol. 188, 36–50
Reinhold, D., Bank, U., Bühling, F., Kähne, T., Kunz, D., Faust, J., Neubert, K., Ansorge, S. (1994) Inhibitors of Dipeptidyl peptidase IV (DPIV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells. Immunbiol. 192, 121–136
Murata, M., Kubota, Y., Tanaka, T., lida-Tanaka, K., Takahara, J., Inno, S. (1994) Effect of ubenimex on the proliferation and differentation of U937 human histiocytic lymphoma cells. Leukemia 8, 2188–2193
Shibuya, K., Chiba, S., Hino, M., Kitamura, T., Miyagawa, K., Takaku, F., Miyazano, K. (1991) Enhancing effect of ubenimex (Bestatin) on proliferation and differentiation of hematopoietic progenitor cells, and the suppressive effect on proliferation of leukemic cell lines via peptidase regulation. Biomed. Pharmacother. 45, 71–80
Hass, R., Meinhardt, G., Hadam, M., Bartels, H. (1994) Characterization of human TUR leukemia cells: continued cell cycle progression in the presence of phorbol esters is associated with the resistance to apoptosis. Eur. J. Cell. Biol. 65, 408–416
Hinter, H.J. (1984) Characterization of human alanine aminopeptidases. Symposia Biologica Hungaria 25
Maclntyre, E.A.,Roberts, P.J., Jones, M., van der Schoot, C.E., Favalaro,E.J., Tidman, N., Linch, D.C. (1989) Activation of human monocytes occurs on cross-linking monocytic antigens to an Fc receptor. J. Immunol. 142, 2377–2383
Maclntyre, E.A.,Roberts, P.J.,Abdul-Gaffar, R., O’Flynn, K., Pilkington, G.R., Farace, F., Morgan, J., Linch, D.C. (1988) Mechanism of human monocytes activation via the 40-kDa Fe-receptor for IgG. J. Immunol. 141, 4333–4343
Hollenberg, M. D. (1996) Protease-mediated signalling: new paradigms for cell regulation and drug devcloment. TIPS 17, 3–6
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Löhn, M., Mueller, C., Thiele, K., Kähne, T., Riemann, D., Langner, J. (1997). Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells. In: Ansorge, S., Langner, J. (eds) Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology, vol 421. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9613-1_12
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9613-1_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9615-5
Online ISBN: 978-1-4757-9613-1
eBook Packages: Springer Book Archive