Abstract
Cholinergic systems have long been implicated in memory processes since anticholinergic drugs disrupt performance on memory tasks in both human (Drachman, 1977; Mewaldt and Ghoneim, 1979) and nonhuman primates (Bartus, 1978; Ridley et al., 1984) and other species (Buresova et al., 1964; Deutsch, 1971; Squire et al., 1971). The source of cholinergic afferents to cerebral cortex has recently been found to lie primarily in the nucleus basalis of Meynert (NBM) (Lehman et al., 1980; Johnston et al., 1981; Mesulam et al., 1983; Pearson et al., 1983). Moreover, both the number of neurons in the NBM (Whitehouse et al., 1982; Arendt et al., 1983; Rogers et al., 1985) and the levels of cholinergic markers in cortex (Davies and Maloney, 1976; Perry et al., 1977; White et al., 1977) have consistently been found to be reduced in patients with Alzheimer’s disease. These findings have led to the hypothesis that the NBM may play an important role in learning and memory.
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Arendt, T., Bigl, V., and Tennstedt, A., 1983, Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff’s disease, Acta Neuropathol. 61: 101–108.
Bartus, R. T., 1978, Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: Effects of concurrent administration of physostigmine and methylphenidate with scopolamine, Pharmacol. Biochem. Behay. 9: 833–836.
Bartus, R. T., and Johnson, H. R., 1976, Short-term memory in the rhesus monkey: Disruption from the anticholinergic scopolamine, Pharmacol. Biochem. Behay. 5: 39–46.
Buresova, O., Bures, J., and Bohdanecky, Z., 1964, Effect of atropine on learning, extinction, retention, and retrieval in rats, Psychopharmacology 5: 255–263.
Burton, M. J., Rolls, E. T., and Mora, F., 1976, Effects of hunger on the responses of neurons in the lateral hypothalamus to the sight and taste of food, Exp. Neurol. 51: 668–677.
Casamenti, F., Deffenu, G., Abbamondi, A. L., and Pepeu, G., 1986, Changes in cortical acetylcholine output induced by modulation of the nucleus basalis, Brain Res. Bull. 16: 689–695.
Das, G. D., 1971, Projections of the interstitial nerve cells surrounding the globus pallidus: A study of retrograde changes following cortical ablations in rabbits, Z. Anat. Entwickl. Gesch. 133: 135–160.
Das, G. D., and Kreutzberg, G. W., 1968, Evaluation of interstitial nerve cells in the central nervous system: A correlative study using acetylcholinesterase and Golgi techniques, Ergeb. Anat. Entwickl. Gesch. 41: 158.
Davies, P., and Maloney, A. J. F., 1976, Selective loss of central cholinergic neurons in Alzheimer’s disease, Lancet 2: 1403.
DeLong, M. R., 1971, Activity of pallidal neurons during movement, J. Neurophysiol. 34: 414–427.
Deutsch, J. A., 1971, The cholinergic synapse and the site of memory, Science 174: 788–794.
Drachman, D. A., 1977, Memory and cognitive function in man: Does the cholinergic system have a specific role, Neurology (Minneap.) 27: 783–790.
Dunnett, S. B., 1985, Comparative effects of cholinergic drugs and lesions of nucleus basalis of fimbria—fornix on delayed matching in rats, Psychopharmacology 87: 357–363.
Fuster, J. M., 1973, Unit activity in prefrontal cortex during delayed-response performance: Neuronal correlates of transient memory, J. Neurophysiol. 36: 61–78.
Fuster, J. M., and Alexander, G. E., 1970, Delayed response deficit by cryogenic depression of frontal cortex, Brain Res. 20: 85–90.
Georgopoulos, A. P., DeLong, M. R., and Crutcher, M. D., 1983, Relations between parameters of step-tracking movements and single cell discharge in the globus pallidus and subthalamic nucleus of the behaving monkey, J. Neurosci. 3: 1586–1598.
Goldman, P. S., and Rosvold, H. E., 1970, Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey, Exp. Neurol. 27: 291–304.
Hepler, D. J., Olton, D. S., Wenk, G. L., and Coyle, J. T., 1985, Lesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments, J. Neurosci. 5: 866–873.
Johnston, M. V., McKinney, M., and Coyle, J. T., 1981, Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat, Exp. Brain Res. 43: 159–172.
Kubota, K., and Funahashi, S., 1982, Direction-specific activities of dorsolateral prefrontal and motor cortex pyramidal tract neurons during visual tracking, J. Neurophysiol. 47: 372–376.
Lamour, Y., Dutar, P., Rascol, O., and Jobert, A., 1986, Basal forebrain neurons projecting to the rat frontoparietal cortex: Electrophysiological and pharmacological properties, Brain Res. 362: 122–131.
Lehman, J., Nagy, J. I., Armadja, S., and Fibiger, H. C., 1980, The nucleus basalis magnocellularis: The origin of a cholinergic projection to the neocortex of the rat, Neuroscience 5: 1161–1174.
LoConte, G., Bartolini, L., Casamenti, F., Marconcini-Pepeu, I., and Pepeu, G., 1982, Lesions of cholinergic forebrain nuclei: Changes in avoidance behavior and scopolamine actions, Pharmacol. Biochem. Behay. 17: 933–937.
Mesulam, M., Mufson, E. J., Levey, A. I., and Wainer, B. H., 1983, Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey, J. Comp. Neurol. 214: 170–197.
Metherate, R., Tremblay, N., and Dykes, R. W., 1985, Changes in neuronal function produced in cat primary somatosensory cortex by the iontophoretic application of acetylcholine, Soc. Neurosci. Abstr. 11: 753.
Mewaldt, S. P., and Ghoneim, M. M., 1979, The effects and interactions of scopolamine, physostigmine, and methamphetamine on human memory, Pharmacol. Biochem. Behay. 10: 205–210.
Mitchell, S. J., Richardson, R. T., Baker, F. H., and DeLong, M. R., 1987a, The primate nucleus basalis of Meynert: Neuronal activity related to a visuomotor tracking task, Exp. Brain Res. (in press).
Mitchell, S. J., Richardson, R. T., Baker, F. H., and DeLong, M. R., 1987b, The primate globus pallidus: Neuronal activity related to direction of movement, Exp. Brain Res. (in press).
Mora, F., Rolls, E. T., and Burton, M. J., 1976, Modulation during learning of the responses of neurons in the lateral hypothalamus to the sight of food, Exp. Neurol. 53: 508–519.
Niki, H., and Watanabe, M., 1976, Prefrontal unit activity and delayed response. Relation to cue location versus direction of response, Brain Res. 105: 79–88.
Pearson, R. C. A., Gatter, K. C., Brodai, P., and Powell, T. P. S., 1983, The projection of the basal nucleus of Meynert upon the neocortex in the monkey, Brain Res. 259: 132–136.
Perry, E., Perry, R., Blessed, G., and Tomlinson, B., 1977, Necropsy evidence of central cholinergic deficits in senile dementia, Lancet 1: 189.
Richardson, R. T., and DeLong, M. R., 1984, Activity of nucleus basalis of Meynert neurons during a delayed response task, Soc. Neurosci. Abstr. 10: 128.
Richardson, R. T., and DeLong, M. R., 1986, Differential responses of nucleus basalis of Meynert neurons in a go/no-go task in monkey (Macaca mulatta), Soc. Neurosci. Abstr. 12: 356.
Richardson, R. T., and DeLong, M. R., 1986, Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey, Brain Res. 399: 364–368.
Richardson, R. T., Mitchell, S. J., Baker, F. H., and DeLong, M. R., 1983, Activity of neurons in the macaque nucleus basalis of Meynert in a visuomotor tracking task, Soc. Neurosci. Abstr. 9: 951.
Ridley, R. M., Bowes, P. M., Baker, H. F., and Crow, T. J., 1984, An involvement of acetylcholine in object discrimination learning and memory in the marmoset, Neuropsychologia 22: 252–263.
Rogers, J. D., Brogan, D., and Mirra, S. S., 1985, The nucleus basalis of Meynert in neurological disease: A quantitative morphological study, Ann. Neurol. 17: 163–170.
Rolls, E. T., Burton, M. J., and Mora, F., 1976, Hypothalamic neuronal responses associated with the sight of food, Brain Res. 111: 53–66.
Rolls, E. T., Sanghera, M. K., and Roper-Hall, A., 1979, The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey, Brain Res. 164: 121–135.
Rosenkilde, C. E., 1979, Functional heterogeneity of the prefrontal cortex in the monkey: A review, Behay. Neurol. Biol. 25: 301–345.
Rosvold, H. E., and Szwarcbart, M. K., 1964, Neural structures involved in delayed-response performance, in: The Frontal Granular Cortex and Behavior ( K. Akert, ed.), McGraw-Hill, New York, pp. 1–15.
Shute, C. C. D., and Lewis, P. R., 1967, The ascending cholinergic reticular system: Neocortical, olfactory and subcortical projections, Brain 90: 497–519.
Squire, L. R., Glick, S. D., and Goldfarb, J., 1971, Relearning at different times after training as affected by centrally and peripherally acting cholinergic drugs in the mouse, J. Comp. Physiol. Psychol. 74: 41–45.
Stewart, D. J., Macfabe, D. F., and Vanderwolf, C. H., 1984, Cholinergic activation of the electrocorticogram: Role of the substantia innominata and effects of atropine and quinuclidinyl benzilate, Brain Res. 322: 219–232.
White, P., Goodhardt, M. J., and Keet, J. P., 1977, Neocortical cholinergic neurons in elderly people, Lancet 1: 668–671.
Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and DeLong, M. R., 1982, Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain, Science 215: 1237–1239.
Wilson, F. A., Rolls, E. T., Yaxley, S., Thorpe, S. J., Williams, G. V., and Simpson, S. J., 1984, Responses of neurons in the basal forebrain of the behaving monkey, Soc. Neurosci. Abstr. 10: 128.
Woody, C. D., 1982, Acquisition of conditioned facial reflexes in the cat: Cortical control of different facial movements, Fed. Proc. 41 (6): 2160–2168.
Woody, C. D., Swartz, B. E., and Gruen, E., 1978, Effects of acetylcholine and cyclic GMP on input resistance of cortical neurons in awake cats, Brain Res. 158: 373–395.
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Richardson, R.T., Mitchell, S.J., Baker, F.H., DeLong, M.R. (1988). Responses of Nucleus Basalis of Meynert Neurons in Behaving Monkeys. In: Woody, C.D., Alkon, D.L., McGaugh, J.L. (eds) Cellular Mechanisms of Conditioning and Behavioral Plasticity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9610-0_16
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