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New Strategies for the Improvement of Alkylating Antitumor Agents

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Cancer Biology and Therapeutics

Abstract

Concepts for an improvement of alkylating antitumor agents are generally based on the assumption that alkylation of DNA, especially the formation of DNA-interstrand cross-links, is the essential mechanism which causes growth inhibition of tumor cells. However, although most authors agree that alkylation of DNA may be important, definite proof that this is the one and only mechanism by which alkylating drugs inhibit cell proliferation is still lacking. For review see Wilman and Connors (1).

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Authors and Affiliations

  1. Institut fur Medizinische Chemie and Biochemie, Universitat Innsbruck, Innsbruck, Austria

    H. Grunicke, W. Doppler, J. Hofmann, H. Lindner, K. Maly, H. Oberhuber, B. Puschendorf & H. Ringsdorf

Authors
  1. H. Grunicke
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  2. W. Doppler
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  3. J. Hofmann
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  4. H. Lindner
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  5. K. Maly
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  6. H. Oberhuber
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  7. B. Puschendorf
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  8. H. Ringsdorf
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Joseph G. Cory  & Andor Szentivanyi  & 

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Grunicke, H. et al. (1987). New Strategies for the Improvement of Alkylating Antitumor Agents. In: Cory, J.G., Szentivanyi, A. (eds) Cancer Biology and Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9564-6_9

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  • DOI: https://doi.org/10.1007/978-1-4757-9564-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9566-0

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