Abstract
Toxigenic strains of Clostridium botulinum produced seven immunological distinct neurotoxins, type A-G. Neurotoxins are 150-kDa proteins, synthesized as single chain molecules and nicked to the dichain form by endogenous protease(s) in the bacterial culture. Dichain form consists of a heavy chain (approx. 100 kDa) and a light chain (approx. 50 kDa) held together by at least one disulfide bond and noncovalent bonds.
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Yokosawa, N., Kimura, K., Tsuzuki, K., Fujii, N., Syuto, B., Oguma, K. (1993). Inhibition of Norepinephrine Secretion from Digitonin Permeabilized PC12 Cells by C. Botulinum Type D Toxin. In: DasGupta, B.R. (eds) Botulinum and Tetanus Neurotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9542-4_34
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DOI: https://doi.org/10.1007/978-1-4757-9542-4_34
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