Abstract
Complement was first described as a heat-labile component in serum with bactericidal activity. It was subsequently found to also participate in many aspects of host defense against infection, including the initiation of inflammation, opsonization of microorganisms, and regulation of the immune response. To date, most, if not all, of the serum proteins that constitute the complement system have been identified and their activities characterized. Three types of interactions may be described for the complement proteins: (i) with each other, resulting in the sequential activation of the complement components in a cascade manner as well as in the regulation of such activation; (ii) with surface components of target cells, leading to their opsonization by the covalent binding of activated C3 and C4 fragments, and their cytolysis by the insertion of the terminal complex into the membrane; and (iii) with receptors on cells and tissues to bring about various immunologic responses. In this chapter, the structure and function of the complement receptors on the macrophage and related cells are described.
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References
Ahearn, J. M., and Fearon, D. T., 1989, Structure and function of the complement receptors, CR (CD35) and CR (CD21), Adv. Immunol. 46: 183–219.
Altieri, D. C., and Edgington, T. S., 1988a, A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD1 lb/CD18 (Mac-1), J. Immunol. 141: 2656–2660.
Altieri, D. C., and Edgington, T. S., 1988b, The saturable high affinity association of factor X to ADP-stim- ulated monocytes defines a novel function of the Mac-1 receptor, J. Biol. Chem. 263: 7007–7015.
Altieri, D. C., Bader, R., Mannucci, P. M., and Edgington, T. S., 1988a, Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen, J. Cell Biol. 107: 1893–1900.
Altieri, D. C., Morrissey, J. H., and Edgington, T. S., 1988b, Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: An alternative initiation of the coagulation protease cascade, Proc. Natl. Acad. Sci. USA 85: 7462–7466.
Ambrus, J. L., Peters, M. G., Fauci, A. S., and Brown, E. J., 1990, The Ba fragment of complement factor B inhibits human B lymphocyte proliferation, J. Immunol. 144: 1549–1553.
Arnaout, M. A., 1990, Leukocyte adhesion molecules deficiency: Its structural basis, pathophysiology and implications for modulating the inflammatory response, Immunol. Rev. 114: 145–180.
Arnaout, M. A., Todd, R. F., Dana, N., Melamed, J., Schlossman, S. F., and Colten, H. R., 1983, Inhibition of phagocytosis of complement C3– or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol), J. Clin. Invest. 72: 171–179.
Arnaout, M. A., Gupta, S. K., Pierce, M. W., and Tenen, D. G., 1988a, Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mol (complement receptor type 3), J. Cell Biol. 106: 2153–2158.
Arnaout, M. A., Lanier, L. L., and Faller, D. V., 1988b, Relative contribution of the leukocyte molecules Mol, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue-and stimulus-specific, J. Cell. Physiol. 137: 305–309.
Arvieux, J., Reboul, A., Bensa, J. C., and Colomb, M. G., 1984, Characterization of the C 1 q receptor on a human macrophage cell line U937, Biochem. J. 218: 547–555.
Atkinson, J. P., and Frank, M. M., 1974, The effect of bacillus Calmette-Guerin induced macrophage activation on the in vivo clearance of sensitised erythrocytes, J. Clin. Invest. 53: 1742–1749.
Axline, S. G., and Reaven, E. P., 1974, Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B: Role of subplasmalemmal microfilaments, J. Cell Biol. 62: 647–659.
Baatrup, G., Thiel, S., Isager, H., Svehag, S. E., and Jensenius, J. C., 1987, Demonstration in human plasma of a lectin activity analogous to that of bovine conglutinin, Scand. J. Immunol. 26: 355–361.
Bainton, D. F., Miller, L. J., Kishimoto, T. K., and Springer, T. A., 1987, Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophile, J. Exp. Med. 166: 1641–1653.
Barlow, P. N., Baron, M., Norman, D. G., Day, A. J., Willis, A. C., Sim, R. B., and Campbell, I. D., 1991, Secondary structure of a complement control protein module by two-dimensional ‘H NMR, Biochemistry 30: 997–1004.
Becherer, J. D., and Lambris, J. D., 1988, Identification of the C3b receptor-binding domain in third component of complement, J. Biol. Chem. 263: 14586–14591.
Becherer, J. D., Alsenz, J., and Lambris, J. D., 1989, Molecular aspects of C3 interactions and structural/ functional analysis of C3 from different species, Curr. Top. Microbiol. Immunol. 153: 45–72
Becker, E. L., Kermode, J. L., Naccache, P. H., Yassin, R., Marsh, M. L., Munoz, I. J., and Sha’afi, R. I., 1985, The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin, J. Cell. Biol. 100: 1641–1646.
Becker, S., Hadding, U., Schorlemmer, H. U., and Bitter-Suermann, D., 1978a, Demonstration of highaffinity binding sites for C3a anaphylatoxin on guinea-pig platelets, Scand. J. Immunol. 8: 551–555
ecker, S., Meuer, S., Hadding, U., and Bitter-Suermann, D., 1978b, Platelet activation: A new biological activity of guinea-pig C3a anaphylatoxin, Scand. J. Immunol. 7: 173–180.
Beer, J., and Coller, B. S., 1989, Evidence that platelet glycoprotein IIIa has a large disulfide-bonded loop that is susceptible to proteolytic cleavage, J. Biol. Chem. 264: 17564–17573.
Beller, D. I., Springer, T. A., and Schreiber, R. D., 1982, Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor, J. Exp. Med. 156: 1000–1009.
Belt, K. T., Carroll, M. C., and Porter, R. R., 1984, The structural basis of the multiple forms of human complement component C4, Cell 36: 907–914.
Belt, K. T., Yu, C. Y., Carroll, M. C., and Porter, R. R., 1985, Polymorphism of human complement component C4, Immunogenetics 21: 173–180.
Ben-Chetrit, E., Chan, E. K. L., Sullivan, K. F., and Tan, E. M., 1988, A 52–KD protein is a novel component of the SS-A/Ro antigenic particle, J. Exp. Med. 167: 1560–1571.
Bentley, D. R., 1986, Primary structure of human complement component C2: Homology to two unrelated protein families, Biochem. J. 239: 339–345.
Berger, M., Gaither, T. A., Hammer, C. H., and Frank, M. M., 1981, Lack of binding of human C3, in its native state, to C3b receptors, J. Immunol. 127: 1329–1334.
Berger, M., O’Shea, J., Cross, A. S., Folks, T. M., Chused, T. M., Brown, E. J., and Frank, M. M., 1984, Human neutrophils increase expression of C3bi as well as C3b receptors upon activation, J. Clin. Invest. 74: 1566–1571.
Bianco, C., Griffin, F. M., and Silverstein, S. C., 1975, Studies of the macrophage complement receptor: Alteration of receptor function upon macrophage activation, J. Exp. Med. 141: 1279–1290.
Bitter-Suermann, D., 1988, The anaphylatoxins, in The Complement System ( K. Rother and G. O. Till, eds.), pp. 367–395, Springer-Verlag, Berlin.
Bobak, D. A., Gaither, T. A., Frank, M. M., and Tenner, A. J., 1987, Modulation of FcR function by complement: Subcomponent Clq enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages, J. Immunol. 138: 1150–1156.
Bobak, D. A., Frank, M. M., and Tenner, A. J., 1988a, CIq acts synergistically with phorbol dibutyrate to activate CR1–mediated phagocytosis by human mononuclear phagocytes, Eur. J. Immunol. 18: 2001–2007.
Bobak, D. A., Washburn, R. G., and Frank, M. M., 1988b, CI q enhances the phagocytosis of Cryptococcus neofbrmans blastospores by human monocytes, J. Immunol. 141: 592–597.
Bohnsack, J. F., Kleinman, H. K., Takahashi, T., O’Shea, J. J., and Brown, E. J., 1985, Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fe-mediated phagocytosis by cultured human macrophages, J. Exp. Med. 161: 912–923.
Bohnsack, J. F., Akiyama, S. K., Damsky, C. H., Knape, W. A., and Zimmerman, G. A., 1990, Human neutrophil adherence to laminin in vitro: Evidence for a distinct neutrophil integrin receptor for laminin, J. Exp. Med. 171: 1221–1237.
Bokisch, V. A., and Müller-Eberhard, H. J., 1970, Anaphylatoxin inactivator of human plasma: Its isolation and characterization as a carboxypeptidase, J. Clin. Invest. 49: 2427–2436.
Bokisch, V. A., Müller-Eberhard, H. J., and Cochrane, C. G., 1969, Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum, J. Exp. Med. 129: 1109–1130.
Bora, N. S., Lublin, D. M., Kumar, B. V., Hockett, R. D., Holers, V. M., and Atkinson, J. P., 1989
Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3’ end of the C3b/C4b receptor gene, J. Exp. Med. 169:597–602.
Boulay, F., Tardif, M., Brouchan, L., and Vignais, P., 1990, The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors, Biochemistry 29: 11123–11133.
Boulay, F., Mery, L., Tardif, M., Brouchon, L., and Vignais, P., 1991, Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells, Biochemistry 30: 2993–2999.
Brown, E. J., and Goodwin, J. L., 1988, Fibronectin receptors of phagocytes: Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes, J. Exp. Med. 167: 777–793.
Brown, E. J., Bohnsack, J. F., and Gresham, H. D., 1988, Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen, J. Clin. Invest. 81: 365–375.
Bullock, W. E., and Wright, S. D., 1987, Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages, J. Exp. Med. 165: 195–210.
Burmeister, M., Kim, S., Price, R., de Lange, T., Tantravahi, U., Myers, R. M., and Cox, D. R., 1991, A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis, Genomics 9: 19–30.
Burton, D. R., and Woof, J. M., 1992, Human antibody effector function, Adv. Immunol. 51: 1–84.
Buyon, J. P., Slade, S. G., Reibman, J., Abramson, S. B., Philips, M. R., Weissmann, G., and Winchester, R., 1990, Constitutive and induced phosphorylation of the a-and ß-chains of the CD!1 /CD 18leukocyte integrin family, J. Immunol. 144: 191–197.
Calvete, J. J., Alvarez, M. V., Rivas, G., Hew, C. L., Henschen, A., and Gonzalez-Rodriguez, J., 1989a, Interchain and intrachain disulphide bonds in human platelet glycoprotein IIb. Localization of the epitopes for several monoclonal antibodies, Biochem. J. 261: 551–560.
Calvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J., 1989b, Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the alpha-subunit of human platelet glycoprotein IIb, Biochem. J. 261: 561–568.
Calvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J., 1991, Assignment of disulphide bonds in human platelet GPIIIa: A duslphide pattern for the ß-subunits of the integrin family, Biochem. J. 274: 63–71.
Campbell, R. D., Dodds, A. W., and Porter, R. R., 1980, The binding of human complement component C4 to antibody-antigen aggregates, Biochem. J. 189: 67–80.
Campbell, R. D., Gagnon, J., and Porter, R. R., 1981, Amino acid sequence around the thiol and reactive acyl groups of human complement component C4, Biochem. J. 199: 359–370.
Caporale, L. H., Tippett, P. S., Ericson, B. W., and Hugh, T. E., 1980, The active site of C3a anaphylatoxin, J. Biol. Chem. 255: 10758–10763.
Caras, I. W., Davitz, M. A., Rhee, L., Weddell, G., Martin, D. W. J., and Nussenzweig, V., 1987, Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins, Nature (London) 325: 545–549.
Carlo, J. R., Ruddy, S., Studer, E. J., and Conrad, D. H., 1979, Complement receptor binding of C3b- coated cells treated with C3b inactivator, ß1H globulin and trypsin, J. Immunol. 123: 523–528.
Carrell, N. A., Fitzgerald, L. A., Steiner, B., Erickson, H. P., and Phillips, D. R., 1985, Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy, J. Biol. Chem. 260: 1743–1749.
Carroll, M. C., Alicot, E. M., Katzman, P. J., Klickstein, L. B., Smith, J. A., and Fearon, D. T., 1988, The organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4–binding protein in the RCA locus on human chromosome 1, J. Exp. Med. 167: 1271–1280.
Changelian, P. S., and Fearon, D. T., 1986, Tissue-specific phosphorylation of complement receptors CR1 and CR2, J. Exp. Med. 163: 101–115.
Chatila, T. A., Geha, R. S., and Arnaout, M. A., 1989, Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules, J. Cell Biol. 109: 3435–3444.
Chazin, W. J., Hugh, T. E., and Wright, P. E., 1988, ‘H NMR studies of human C3a anaphylatoxin in solution: Sequential resonance assignments, secondary structure, and global fold, Biochemistry 27: 9139–9148.
Chenoweth, D. E., 1986, Complement mediators of inflammation, in Immunobiology of the Complement System. An Introduction for Research and Clinical Medicine ( G. D. Ross, ed.), pp. 63–86, Academic Press, Orlando, Fla.
Chenoweth, D. E., and Hugh, T. E., 1978, Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. USA 75: 3943–3947.
Chou, P. Y., and Fasman, G. D., 1978, Empirical predictions of protein conformation, Annu. Rev. Biochem. 47: 251–276.
Chung, L. P., Bentley, D. R., and Reid, K. B. M., 1985, Molecular cloning and characterisation of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system, Biochem. J. 230: 133–141.
Clas, F., Euteneuer, B., Stemmer, F., and Loos, M., 1989, Interaction of fluid phase Cl/Cl q and macro- phage membrane-associated Clq with gram-negative bacteria, Behring Inst. Mitt. 84: 236–254.
Cochrane, C. G., and Müller-Eberhard, H. J., 1968, The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement, J. Exp. Med. 127: 371–386.
Codina, J., Hildebrandt, J., Iyengar, R., Birnbaumer, L., Sekura, R. D., and Manclark, C. R., 1983, Pertussis toxin substrate, the putative Ni component of adenylyl cyclase, is an alpha-beta heterodimer regulated by guanine nucleotide and magnesium, Proc. Natl. Acad. Sci. USA 80: 4276–4280.
Coller, B. S., 1985, A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex, J. Clin. Invest. 76: 101–108.
Cooper, J. A., Lo, S. K., and Malik, A. B., 1988, Fibrin is a determinant of neutrophil sequestration in the lung, Circ. Res. 63: 735–741.
Cooper, N. R., 1969, Immune adherence by the fourth component of complement, Science 165: 396–398.
Corbi, A. L., Miller, L. J., O’Connor, K., Larson, R. S., and Springer, T. A., 1987, cDNA cloning and complete primary structure of the a subunit of a leukocyte adhesion glycoprotein, p150,95, EMBO J. 6: 4023–4028.
Corbi, A. L., Kishimoto, T. K., Miller, L. J., and Springer, T. A., 1988a, The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD 11 b) a subunit: Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B, J. Biol. Chem. 263: 12403–12411.
Corbi, A. L., Larson, R. S., Kishimoto, T. K., Springer, T. A., and Morton, C. C., 1988b, The leukocyte adhesion receptors LFA-1, Mac-1 and p150,95: Identification of a gene cluster involved in cell adhesion, J. Exp. Med. 167: 1597–1607.
Cornacoff, J. B., Herbert, L. A., Smead, W. L., Vanaman, M. E., Birmingham, D. J., and Waxman, F. J., 1983, Primate erythrocyte immune-complex clearing mechanism, J. Clin. Invest. 71: 236–247
Craddock, P. R., Hammerschmidt, D., White, J. G., Dalmasso, A. P., and Jacob, H. S., 1977, Complement (C5a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostatis and leukopenia, J. Clin. Invest. 60: 260–264.
Dana, N., Fathallah, D. M., and Arnaout, M. A., 1991, Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18, Proc. Natl. Acad. Sci. USA 88: 3106–3110.
Davis, A. E., and Lachmann, P. J., 1984, Bovine conglutinin is a collagen-like protein, Biochemistry 23: 2139–2144.
Davis, A. E., Harrison, R. A., and Lachmann, P. J., 1984, Physiologic inactivation of fluid phase C3b: Isolation and structural analysis of C3c, C3dg (a2D) and C3g, J. Immunol. 132: 1960–1966.
Day, A. J., Ripoche, J., Willis, A. C., and Sim, R. B., 1987, Structure and polymorphism of human factor H, Complement 4: 147–148.
de Bruijn, M. H. L., and Fey, G. H., 1985, Human complement component C3: cDNA coding sequence and derived primary structure, Proc. Natl. Acad. Sci. USA 82: 708–712.
del-Balzo, U., Polley, M. J., and Levi, R., 1989, C3a-induced contraction of guinea pig ileum consists of two components: Fast histamine-mediated and slow prostanoid-mediated, J. Pharmacol. Exp. Ther. 248: 1003–1009.
Diamond, M. S., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., Garcia-Aguilar, J., Hibbs, M. L., and Springer, T. A., 1990, ICAM-1 (CD54): A counter-receptor for Mac-1 (CD1 1 b/CD18), J. Cell Biol. 111: 3129–3139.
Diamond, M. S., Staunton, D. E., Marlin, S. D., and Springer, T. A., 1991, Binding of the integrin Mac-1 (CD1 lb/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation, Cell 65: 961–971.
DiScipio, R. G., and Hugli, T. E., 1989, The molecular architecture of human complement component C6, J. Biol. Chem. 264: 16197–16206.
DiScipio, R. G., Chakravarti, D. N., Müller-Eberhard, H. J., and Fey, G. H., 1988, The structure of human complement component C7 and C5b-7 complex, J. Biol. Chem. 263: 549–560.
Dransfield, I., and Hogg, N., 1989, Regulated expression of Mgt+ binding epitope on leukocyte integrin alpha subunits, EMBO J. 8: 3759–3765.
Drickamer, K., 1989, Multiple subfamilies of carbohydrate recognition domains in animal lectins, Ciba Found. Symp. 145: 45–58.
Dykman, T. R., Cole, J. L., Iida, K., and Atkinson, J. P., 1983, Polymorphism of the human erythrocyte C3b-C4b receptor, Proc. Natl. Acad. Sci. USA 80: 1698–1702.
Ember, J. A., Johansen, N. L., and Hugli, T. E., 1991, Designing synthetic superagonists of C3a anaphylatoxin, Biochemistry 30: 3603–3612.
Erdei, A., 1990, Clq receptor on murine cells, J. Immunol. 145: 1754–1760.
Erdei, A., and Reid, K. B. M., 1988, The Clq receptor, Mol. Immunol. 25: 1067–1073.
Erdei, A., and Sim, R. B., 1987, Complement factor H-binding protein of Raji cells and tonsil B lymphocytes, Biochem. J. 246: 149–156.
Ezekowitz, R. A. B., Kuhlman, M., Groopman, J. E., and Byrn, R. A., 1989, A human serum mannosebinding protein inhibits in vitro infection by the human immunodeficiency virus, J. Exp. Med. 169: 185–196.
Fearon, D. T., 1980, Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte and monocyte, J. Exp. Med. 152: 20–30.
Fearon, D. T., and Collins, L. A., 1983, Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures, J. Immunol. 130: 370–375.
Fernandez, H. N., and Hugh, T. E., 1978, Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin, J. Biol. Chem. 253: 6955–6964.
Fernandez, H. N., Henson, P. M., Otani, A., and Hugh, T. E., 1978, Chemotaxis response to human C3a and C5a anaphylatoxins. I. Evaluations of C3a and C5a leukotaxis in vitro and under simulated in vivo conditions, J. Immunol. 120: 109–115.
Floros, J., Steinbrink, R., Jacobs, K., Phelps, D., Kriz, R., Recny, M., Sultzman, L., Jones, S., Taeusch, H. W., Frank, H. A., and Fritch, E. F., 1986, Isolation and characterization of cDNA clones for the 35–kDa pulmonary surfactant-associated protein, J. Biol. Chem. 261: 9029–9033.
Friis-Christiansen, P., Thiel, S., Svehag, S. E., Dessau, R., Svendsen, P., Andersen, O., Laursen, S. B., and Jensenius, J. C., 1990, In vivo and in vitro antibacterial activity of conglutinin, a mammalian plasma lectin, Scand. J. Immunol. 31: 453–460.
Fujita, T., Gigli, I., and Nussenzweig, V., 1978, Human C4–binding protein. II. Role in proteolysis of C4b by C3b-inactivator, J. Exp. Med. 148: 1044–1051.
Fukuoka, Y., and Hugh, T. E., 1988, Demonstration of a specific C3a receptor on guinea pig platelets, J. Immunol. 140: 3496–3501.
Gerard, C., and Hugh, T. E., 1981, Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: Evidence of a modulator role for the oligosaccharide unit in human des-Arg74–05a, Proc. Natl. Acad. Sci. USA 78: 1833–1837.
Gerard, N. P., and Gerard, C., 1990, Construction and expression of a novel recombinant anaphylatoxin, C5a-N 19, as a probe for the human C5a receptor, Biochemistry 29: 9274–9281.
Gerard, N. P., and Gerard, C., 1991, The chemotactic receptor for human C5a anaphylatoxin, Nature (London) 349: 614–617.
Gerardy-Schahn, R., Ambrosius, D., Casaretto, M., Grötzinger, J., Saunders, D., Wollmer, A., Brandenburg, D., and Bitter-Suermann, D., 1988, Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements, Biochem. J. 255: 209–216.
Gerardy-Schahn, R., Ambrosius, D., Saunders, D., Casaretto, M., Mittler, C., Karwarth, G., Gorgen, S., and Bitter-Suermann, D., 1989, Characterization of C3a receptor-proteins on guinea pig platelets and human polymorphonuclear leukocytes, Eur. J. Immunol. 19: 1095–1102.
Ghebrehiwet, B., 1989, Functions associated with the Clq receptor, Behring Inst. Mitt. 84: 204–215.
Ghebrehiwet, B., Silvestri, L., and McDevitt, C., 1984, Identification of the Raji cell membrane-derived Clq inhibitor as a receptor for human Clq. Purification and immunochemical characterization, J. Exp. Med. 160: 1375–1389.
Ghebrehiwet, B., Habicht, G. S., and Beck, G., 1990, Interaction of Clq with its receptor on cultured cell lines induces an anti-proliferative response, Clin. Immunol. Immunopatho!. 54: 148–159.
Goldman, D. W., Chang, F. H., Gifford, L. A., Goetzl, E. J., and Bourne, H. R., 1985, Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes, J. Exp. Med. 162: 145–156.
Gorski, J., Hugh, T. E., and Muller-Eberhard, H. J., 1979, C4a: The third anaphylatoxin of the human complement system, Proc. Natl. Acad. Sci. USA 76: 5299–5302.
Goundis, D., 1988, Structure, biosynthesis and cDNA cloning studies of properdin of the serum complement system, D. Phil. Thesis, Oxford University.
Graham, I. L., and Brown, E. J., 1991, Extracellular calcium results in a conformational change in Mac-1 (CD11b/CD18) on neutrophils. Differentiation of adhesion and phagocytosis functions of Mac-1, J. Immunol. 146: 685–691.
Graham, I. L., Gresham, H. D., and Brown, E. J., 1989, An immobile subset of plasma membrane CD1lb/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors, J. Immunol. 14: 2352–2358.
Greer, J., 1985, Model structure for the inflammatory protein C5a, Science 228: 1055–1060.
Gresham, H. D., Goodwin, J. L., Allen, P. M., Anderson, D. C., and Brown, E. J., 1989, A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis, J. Cell Biol. 108: 1935–1943.
Griffin, F. M., Jr., and Griffin, J. A., 1980, Augmentation of macrophage complement receptor function in vitro. II. Characterization of the effects of a unique lymphokine upon the phagocytic capabilities of macrophages, J. Immunol. 125: 844–849.
Griffin, F. M., Jr., and Mullinax, P. J., 1981, Augmentation of macrophage complement receptor function in vitro. III. C3b receptors that promote phagocytosis migrate within the plane of the macrophage plasma membrane, J. Exp. Med. 154: 291–305.
Griffin, J. A., and Griffin, F. M., Jr., 1979, Augmentation of macrophage complement receptor function in vitro. I. Characterization of the cellular interactions required for the generation of a T-lymphocyte product that enhances macrophage complement receptor function, J. Exp. Med. 150: 653–675.
Guan, E., Burgess, W. H., Robinson, S. L., Goodman, E. B., McTigue, K. J., and Tenner, A. J., 1991, Phagocytic cell molecules that bind the collagen-like region of Cl q. Involvement in the C 1 q-mediated enhancement of phagocytosis, J. Biol. Chem. 266: 20345–20355.
Haagsman, H. P., White, R. T., Schilling, J., Lau, K., Benson, B. J., Golden, J., Hawgood, S., and Clements, J. A., 1989, Studies of the structure of lung surfactant protein SP-A, Am. J. Physiol. 257: L421–L429.
Habicht, G. S., Beck, G., and Ghebrehiwet, B., 1987, C lq inhibits the expression of B lymphoblastoid cell line interleukin 1 (IL I), J. Immunol. 138: 2593–2597.
Haefliger, J. A., Tschopp, J., Vial, N., and Jenne, D. E., 1989, Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6, J. Biol. Chem. 264: 18041–18051.
Hamada, A., Young, J., Chmielewski, R. A., and Green, B. M., 1988, Clq enhancement of antibody-dependent granulocyte-mediated killing of nonphagocytosable targets in vitro, J. Clin. Invest. 82: 945–949.
Harlan, J. M., 1985, Leukocyte-endothelial interactions, Blood 65: 513–525.
Harrison, R. A., and Lachmann, P. J., 1980, The physiological breakdown of the third component of human complement, Mol. Immunol. 17: 9–20.
Harrison, R. A., Thomas, M. L., and Tack, B. F., 1981, Sequence determination of the thiolester site of the fourth component of human complement, Proc. Natl. Acad. Sci. USA 78: 7388–7392.
Hemler, M. E., 1990, VLA proteins in the integrin family: Structures, functions, and their role on leukocytes, Annu. Rev. Immunol. 8: 365–400.
Hickstein, D. D., Hickey, M. J., Ozols, J., Baker, D. M., Back, A. L., and Roth, G. J., 1989, cDNA sequence for the aM subunit of the human neutrophil adherence receptor indicates homology to integrin a subunits, Proc. Natl. Acad. Sci. USA 86: 257–261.
Hillarp, A., and Dahlbäck, B., 1990, Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: Sequence homology with the alpha chain, Proc. Natl. Acad. Sci. USA 87: 1183–1187.
Hogg, N., Takacs, L., Palmer, D. G., Salvendran, Y., and Allen, C., 1986, The p 150,95 molecule is a marker of human mononuclear phagocytes: A comparison with expression of class II molecules, Eur. J. Immunol. 16: 240–248.
Holers, V. M., Chaplin, D. D., Leykam, J. F., Gruner, B. A., Kumar, V., and Atkinson, J. P., 1987, Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism, Proc. Natl. Acad. Sci. USA 84: 2459–2463.
Hourcade, D., Garcia, A. D., Post, T. W., Taillon-Miller, P., Holens, V. M., Wagner, L. M., Bora, N. S., and Atkinson, J. P., 1992, Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs), Genomics 12: 289–300.
Huber, R., Scholze, H., Pâques, E. P., and Deisenhofer, J., 1980, Crystal structure analysis and molecular model of human C3a anaphylatoxin, Hoppe-Seyler’s Z. Physiol. Chem. 361: 1389–1399.
Huey, R., and Hugli, T. E., 1985, Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN), J. Immunol. 135: 2063–2068.
Hugli, T. E., 1975, Human anaphylatoxin (C3a) from the third component of complement: Primary structure, J. Biol. Chem. 250: 8293–8301.
Hugh, T. E., 1981, The structural basis for anaphylatoxin and chemotactic functions of C3a, C4a and C5a, CRC Crit. Rev. Immunol. 1: 321–366.
Hugli, T. E., 1989, Structure and function of C3a anaphylatoxin, Curr. Top. Microbiol. Immunol. 153: 181–208.
Hugli, T. E., and Erickson, B. W., 1977, Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin, Proc. Natl. Acad. Sci. USA 74: 1826–1830.
Humphries, M. J., 1990, The molecular basis and specificity of integrin-ligand interactions, J. Cell Sci. 97: 585–592.
Iferroudjene, D., Schouft, M. T., Lemercier, C., Gilbert, D., and Fontaine, M., 1991, Evidence for an active hydrophobic form of factor H that is able to induce secretion of interleukin 1–ß or by human monocytes, Eur. J. Immunol. 21: 967–972.
Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T., and Yamashina, I., 1987, Serum lectin with known structure activates complement through the classical pathway, J. Biol. Chem. 262: 7451–7454.
Isenman, D. E., 1983, Conformational changes accompanying proteolytic cleavage of human complement protein C3b by the regulatory enzyme factor I and its cofactor H, J. Biol. Chem. 258: 4238–4244.
Isenman, D. E., Kells, D. I. C., Cooper, N. R., Müller-Eberhard, H. J., and Pangburn, M. K., 1981, Nucleophilic modification of human complement protein C3: Correlation of conformational changes with acquisition of C3b-like functional properties, Biochemistry 20: 4458–4467.
Janatova, J., and Gobel, R. J., 1985, Activation and fragmentation of the third (C3) and the fourth (C4) components of complement: Generation and isolation of physiologically relevant fragments C3c and C4c, J. Immunol. Methods 85: 17–26.
Janatova, J., Reid, K. B. M., and Willis, A. C., 1987, Implications of disulfide bonds in the structure of C4b-binding protein, Complement 4: 173–174.
Jensenius, J. C., Thiel, S., Baatrup, G., and Holmskov-Nielsen, U., 1985, Human conglutinin-like protein, Biosci. Rep. 5: 901–905.
Jeremiah, S. J., Abbott, C. M., Murad, Z., Povey, S., Thomas, H. J., Solomon, E., DiScipio, R. G., and Fey, G. H., 1990, The assignment of the genes coding for human complement components C6 and C7 to chromosome 5, Ann. Hum. Genet. 54: 141–147.
Jiang, H., Siegel, J. N., and Gewurz, H., 1991, Binding and complement activation by C-reactive protein via the collagen-like region of Clq and inhibition of these reactions by monoclonal antibodies to C-reactive protein and Clq, J. Immunol. 146: 2324–2330.
Johnston, R. B., Jr., Lehmeyer, J. E., and Guthrie, L. A., 1976, Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G, J. Exp. Med. 143: 1551–1557.
Johnson, R. J., and Chenoweth, D. E., 1985, Labeling the granulocyte C5a receptor with a unique photoreactive probe, J. Biol. Chem. 260: 7161–7164.
Journet, A., and Tosi, M., 1986, Cloning and sequencing of full-length cDNA encoding the precursor of human complement component CI r, Biochem. J. 240: 783–787.
Kawasaki, N., Kawasaki, T., and Yamashina, I., 1985, Mannan-binding protein and conglutinin in bovine serum, J. Biochem. (Tokyo) 98: 1309–1320.
Kawasaki, N., Kawasaki, T., and Yamashina, I., 1989, A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity, J. Biochem. (Tokyo) 106: 483–489.
Kay, A. B., and Austen, K. F., 1972, Chemotaxis of human basophil leucocytes, Clin. Exp. Immunol. 11: 557–563.
Kay, A. B., Shin, H. S., and Austen, K. F., 1973, Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylataxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a), Immunology 24: 969–976.
Kishimoto, T. K., O’Connor, K., Lee, A., Roberts, T. M., and Springer, T. A., 1987, Cloning of the ß subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family, Cell 48: 681–690.
Klickstein, L. B., Wong, W. W., Smith, J. A., Weis, J. H., Wilson, J. G., and Fearon, D. T., 1987, Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins, J. Exp. Med. 165: 1095–1112.
Klickstein, L. B., Bartow, T. J., Miletic, V., Rabson, L. D., Smith, J. A., and Fearon, D. T., 1988, Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis, J. Exp. Med. 168: 1699–1717.
Knobel, H. R., Villiger, W., and Isliker, H., 1975, Chemical analysis and electron microscopy studies of human Clq prepared by different methods, Eur. J. Immunol. 5: 78–82.
Krych, M., Hourcade, D., and Atkinson, J. P., 1991, Sites within the complement C3b/C4b receptor important for the specificity of ligand binding, Proc. Natl. Acad. Sci. USA 88: 4353–4357.
Lad, P. M., Olson, C. V., and Smiley, P. A., 1985, Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin, Proc. Natl. Acad. Sci. USA 82: 869–873.
Lambris, J. D., and Ross, G. D., 1982, Characterisation of the lymphocyte membrane receptor for factor H (01H-globulin) with an antibody to anti-factor H idiotype, J. Exp. Med. 155: 1400–1411.
Lanier, L. L., Arnaout, M. A., Schwarting, R., Warner, N. L., and Ross, G. D., 1985, p150/95, third member of the LFA-1 /CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody, Eur. J. Immunol. 15: 713–718.
Larson, R. S., and Springer, T. A., 1990, Structure and function of leukocyte integrins, Immunol. Rev. 114: 181–217.
Larson, R. S., Corbi, A. L., Berman, L., and Springer, T., 1989, Primary structure of the leukocyte function-associated molecule-1 alpha subunit: An integrin with an embedded domain defining a protein superfamily, J. Cell Biol. 108: 703–712.
Law, S. K. A., 1983, The covalent binding reaction of C3 and C4, Ann. N. Y. Acad. Sci. 421: 246–258.
Law, S. K. A., 1988, C3 receptors on macrophages, J. Cell Sci. Suppl. 9: 67–97.
Law, S. K., and Levine, R. P., 1977, Interaction between the third complement protein and cell surface macromolecules, Proc. Natl. Acad. Sci. USA 74: 2701–2705.
Law, S. K. A., and Reid, K. B. M., 1988, Complement (in In Focus series), IRL Press, Oxford, U.K. Law, S. K., Fearon, D. T., and Levine, R. P., 1979a, Action of the C3b-inactivator on cell-bound C3b, J. Immunol. 122: 759–765.
Law, S. K. A., Lichtenberg, N. A., and Levine, R. P., 1979b, Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces, J. Immunol. 123: 1388–1394.
Law, S. K., Lichtenberg, N. A., Holcombe, F. H., and Levine, R. P., 1980, Interaction between the labile binding sites of the fourth (C4) and fifth (CS) human complement proteins and erythrocyte cell membranes, J. Immunol. 125: 634–639.
Law, S. K. A., Gagnon, J., Hildreth, J. E. K., Wells, C. E., Willis, A. C., and Wong, A. J., 1987, The primary structure of the 0–subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor, EMBO J. 6: 915–919.
Lay, W. H., and Nussenzweig, V., 1968, Receptors for complement on leukocytes, J. Exp. Med. 128: 991–1010.
Lee, Y. M., Leiby, K. R., Allar, J., Paris, K., Lerch, B., and Okarma, T. B., 1991, Primary structure of bovine conglutinin, a member of the C-type animal lectin family, J. Biol. Chem. 266: 2715–2723.
Leytus, S. P., Kurachi, K., Sakariassen, K. S., and Davie, E. W., 1986, Nucleotide sequence of the cDNA coding for human complement Clr, Biochemistry 25: 4855–4863.
Lo, S. K., Detmers, P. A., Levin, S. M., and Wright, S. D., 1989a, Transient adhesion of neutrophils to endothelium, J. Exp. Med. 169: 1779–1793.
Lo, S. K., van Seventer, G. A., Levin, S. M., and Wright, S. D., 1989b, Two leukocyte receptors (CD’ la/ CD 18 and CD I 1 b/CD 18) mediate transient adhesion to endothelium by binding to different ligands, J. Immunol. 143: 3325–3329.
Loike, J. D., Sodeik, B., Cao, L., Leucona, S., Weitz, J. I., Detmers, P. A., Wright, S. D., and Silverstein, S. C., 1991, CD l lc/CD18 on neutrophils recognizes a domain at the N terminus of the Aa chain of fibrinogen, Proc. Natl. Acad. Sci. USA 88: 1044–1048.
Lu, J., Thiel, S., Wiedemann, H., Timpl, R., and Reid, K. B. M., 1990, Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2Cls2 complex, of the classical pathway of complement, without involvement of C iq, J. Immunol. 144: 2287–2294.
Lu, J., Willis, A. C., and Reid, K. B. M., 1992, Purification, characterisation and cDNA cloning of human lung surfactant protein D, Biochem. J., 284: 795–802.
Lu, Z. X., Fok, K. F., Erickson, B. W., and Hugli, T. E., 1984, Conformational analysis of COOH-terminal segments of human C3a. Evidence of ordered conformation in an active 21–residue peptide, J. Biol. Chem. 259: 7367–7370.
Lublin, D. M., Liszewski, M. K., Post, T. W., Arce, M. A., Le-Beau, M. M., Rebentisch, M. B., Lemons, L. S., Seya, T., and Atkinson, J. P., 1988, Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins, J. Exp. Med. 168: 181–194.
Malhotra, R., and Sim, R. B., 1989, Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent Clq, Biochem. J. 262: 625–631.
Malhotra, R., Thiel, S., Reid, K. B. M., and Sim, R. B., 1990, Human leukocyte C lq receptor binds other soluble proteins with collagen domains, J. Exp. Med. 172: 955–959.
Malhotra, R., Willis, A. C., and Sim, R. B., 1991, Structural characterisation of C lq receptor, Complement, and Inflammation 8: 188.
Malhotra, V., Hogg, N., and Sim, R. B., 1986, Ligand binding by the p 150,95 antigen of U937 monocytic cells: Properties in common with complement receptor type 3 (CR3), Eur. J. Immunol. 16: 1117–1123.
Mantovani, B., Rabinovitch, M., and Nussenzweig, V., 1972, Phagocytosis of immune complexes by macrophages: Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG), J. Exp. Med. 135: 780–792.
Marlin, S. D., and Springer, T. A., 1987, Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1), Cell 51: 813–819.
Marlin, S. D., Morton, C. C., Anderson, D. C., and Springer, T. A., 1986, LFA-1 immunodeficiency disease—definition of the genetic defect and chromosomal mapping of a and ß subunits of the lymphocyte function associated antigen 1 (LFA-1) by complementation in hybrid cells, J. Exp. Med. 164: 855–867.
McCauliffe, D. P., Lux, F. A., Lieu, T. S., Sanz, I., Hanke, J., Newkirk, M. M., Bachinski, L. L., Itoh, Y., Siciliano, M. J., Reichlin, M., Sontheimer, D. D., and Capra, J. D., 1990, Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen, J. Clin. Invest. 85: 1379–1391.
Medof, M. E., and Oger, J. J. F., 1982, Competition for immune complexes by red cells in human blood, J. Lab. Clin. Immunol. 7: 7–13.
Medof, M. E., Lublin, D. M., Holers, V. M., Ayers, D. J., Getty, R. R., Leykam, J. F., Atkinson, J. P., and Tykocinski, M. L., 1987, Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement, Proc. Natl. Acad. Sci. USA 84: 2007–2011.
Micklem, K. J., and Sim, R. B., 1985, Isolation of complement-fragment-iC3b binding proteins by affinity chromatography: The identification ofp 150,95 as an iC3b-binding protein, Biochem. J. 231: 233–236.
Miller, L. J., Bainton, D. F., Borregaard, N., and Springer, T. A., 1987, Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface, J. Clin. Invest. 80: 535–544.
Moon, K. E., Gorski, J. P., and Hugli, T. E., 1981, Complete primary structure of human C4a anaphylatoxin, J. Biol. Chem. 256: 8685–8692.
Moore, M. D., Cooper, N. R., Tack, B. F., and Nemerow, G. R., 1987, Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes, Proc. Natl. Acad. Sci. USA 84: 9194–9198.
Morley, B. J., and Campbell, R. D., 1984, Internal homologies of the Ba fragment from human complement component factor B, a class III MHC antigen, EMBO J. 3: 153–157.
Morris, K. M., Goldberger, G., and Colten, H. R., 1982, Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line, Science 215: 399–400.
Müller-Eberhard, H. J., Dalmasso, A. P., and Calcott, M. A., 1966, The reaction mechanism of 01C-globulin (C’3) in immune hemolysis, J. Exp. Med. 124: 33–54.
Myones, B. L., Dalzell, J. G., Hogg, N., and Ross, G. D., 1988, Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3, J. Clin. Invest. 82: 640–651.
Nagasawa, S., Ichihara, C., and Stroud, R. M., 1980, Cleavage of C4b by C3b inactivator: Production of a nicked form of C4b, C4b’, as an intermediate cleavage product of C4b by C3b inactivator, J. Immunol. 125: 578–582.
Nehesheim, D. G., Edalji, R. P., Mollison, D. W., Greer, J., and Zuiderweg, R. P., 1988, Secondary structure of complement component C3a anaphylatoxins in solution as determined by NMR spectroscopy: Differences between crystal and solution conformations, Proc. Natl. Acad. Sci. USA 85: 5036–5040.
Nermut, M. V., Green, N. M., Eason, P., Yamada, S S, and Yamada, K. M., 1988, Electron microscopy and structural model of human fibronectin receptor, EMBO J. 7: 4093–4099.
Newman, S. L., Mikus, L. K., and Tucci, M. A., 1991, Differential requirements for cellular cytoskeleton in human macrophage complement receptor-and Fc receptor-mediated phagocytosis, J. Immunol. 146: 967–974.
Nguyen, V. C., Tosi, M., Gross, M. S., Cohen-Haguenauer, O., Jegou-Foubert, C., de-Tand, M. F., Meo, T., and Frezal, J., 1988, Assignment of the complement serine protease genes C I r and C 1 s to chromosome 12 region 12p13, Hum. Genet. 78: 363–368.
Nicholson-Weller, A., Burge, J., Fearon, D. T., Weller, P. F., and Austen, K. F., 1982, Isolation of a human erythrocyte membrane glycoprotein with decay accelerating activity for C3 convertases of the complement system, J. Immunol. 129: 184–189.
Ninomiya, Y., Gordon, M., van der Rest, M., Schmid, T., Linsenmayer, T., and Olsen, B. R., 1986, The developmentally regulated type X collagen gene contains a long open reading frame without introns, J. Biol. Chem. 261: 5041–5050.
Norman, D. G., Barlow, P. N., Baron, M., Day, A. J., Sim, R. B., and Campbell, I. D., 1991, Three-dimensional structure of a complement control protein module in solution, J. Mol. Biol. 219: 717–725.
O’Flaherty, J. T., and Ward, P. A., 1978, Leukocyte aggregation induced by chemotactic factors, Inflammation 3: 177–194.
O’Flaherty, J. T., Kreutzer, D. L., and Ward, P. A., 1978, The influence of chemotactic factors on neutrophil adhesiveness, Inflammation 3: 37–48.
Ohta, M., Okada, M., Yamashina, I., and Kawasaki, T., 1990, The mechanism of carbohydrate mediated- complement activation by the serum mannan-binding protein, J. Biol. Chem. 265: 1980–1984.
Pangburn, M. K., 1986, The alternative pathway, in Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine ( G. D. Ross, ed.), pp. 45–62, Academic Press, Orlando, Fla.
Pangburn, M. K., Schreiber, R. D., and Müller-Eberhard, H. J., 1977, Human complement C3b inactiva-tor: Isolation, characterization, and demonstration of an absolute requirement for the serum protein 01H for cleavage of C3b and C4b in solution, J. Exp. Med. 146: 257–270.
Pardo-Manuel, F., Rey-Campos, J., Hillarp, A., Dahlbäck, B., and Rodriguez de Cordoba, S., 1990, Human genes for the a and ß chains of complement C4b-binding protein are closely linked in a head-totail arrangement, Proc. Natl. Acad. Sci. USA 87: 4529–4532.
Peerschke, E. 1. B., and Ghebrehiwet, B., 1988, Modulation of platelet responses to collagen by Clq receptors, J. Immunol. 144: 221–225.
Peerschke, E. I. B., and Ghebrehiwet, B., 1990, Platelet Clq receptor interactions with collagen-and Clq-coated surfaces, J. Immunol. 145: 2984–2988.
Persson, A., Chang, D., and Crouch, E., 1990, Surfactant protein D is a divalent cation-dependent carbohydrate-binding protein, J. Biol. Chem. 265: 5755–5760.
Peters, M. G., Ambrus, J. L., and Fauci, A. S., 1988, The Bb fragment of complement factor B acts as a B cell growth factor, J. Exp. Med. 168: 1225–1235.
Polley, M. J., and Nachman, R. L., 1983, Human platelet activation by C3a and C3a des arg, J. Exp. Med. 158: 603–615.
Pommier, C. G., Inada, S., Fries, L. F., Takahashi, T., Frank, M. M., and Brown, E. J., 1983, Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes, J. Exp. Med. 157: 1844–1854.
Poncz, M., Eisman, R., Heidenreich, R., Silver, S. M., Vilaire, G., Surrey, S., Schwartz, E., and Bennett, J. S., 1987, Structure of the platelet membrane glycoprotein Ilb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors, J. Biol. Chem. 262: 8476–8482.
Possmayer, F., 1988, A proposed nomenclature for pulmonary surfactant-associated proteins, Am. Rev. Respir. Dis. 138: 990–998.
Reid, K. B. M., 1983, Proteins involved in the activation and control of the two pathways of human complement, Biochem. Soc. Trans. 11: 1–12.
Rey-Campos, J., Rubinstein, P., and Rodriguez de Cordoba, S., 1988, A physical map of the human regulator of complement activation gene cluster linking the complement genes CR 1, CR2, DAF, and C4BP, J. Exp. Med. 167: 664–669.
Ripoche, J., Day, A. J., Harris, T. J. R., and Sim, R. B., 1988, The complete amino acid sequence of human complement factor H, Biochem. J. 249: 593–602.
Rodriguez de Cordoba, S., and Rubinstein, P., 1987, New alleles of C4–binding protein and factor H and further linkage data in the regulator of complement activation (RCA) gene cluster in man, Immunogenetics 25: 267–268.
Rollins, T. E., and Springer, M. S., 1985, Identification of the polymorphonuclear leukocyte C5a receptor, J. Biol. Chem. 260: 7157–7160.
Rollins, T. E., Siciliano, S., Kobayashi, S., Cianciarulo, D. N., Bonilla-Argudo, V., Collier, K., and Springer, M. S., 1991, Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-G1 complex, Proc. Natl. Acad. Sci. USA 88: 971–975.
Rosen, H., and Law, S. K. A., 1989, The leukocyte cell surface receptor(s) for the iC3b product of complement, Curr. Top. Microbiol. Immunol. 153: 99–122.
Ross, G. D., Newman, S L, Lambris, J. D., Devery-Pocius, J. E., Cain, J. A., and Lachmann, P. J., 1983, Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin, J. Exp. Med. 158: 334–352.
Ross, G. D., Cain, J. A., and Lachmann, P. J., 1985a, Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b, J. Immunol. 134: 3307–3315.
Ross, G. D., Thompson, R. A., Walport, M. J., Springer, T. A., Watson, J. V., Ward, R. H. R., Lida, J., Newman, S. L., Harrison, R. A., and Lachmann, P. J., 1985b, Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1, Blood 66: 882–890.
Ross, G. D., Cain, J. A., Myones, B. L., Newman, S. L., and Lachmann, P. J., 1987, Specificity of membrane complement receptor type three (CR3) for beta-glucans, Complement 4: 61–74.
Rothlein, R., Dustin, M. L., Marlin, S. D., and Springer, T. A., 1986, A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1, J. Immunol. 137: 1270–1274.
Ruoslahti, E., 1991, Integrins, J. Clin. Invest. 87: 1–5.
Russell, D. G., and Wright, S. D., 1988, Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of leishmania promastigotes, J. Exp. Med. 168: 279–292.
Sanchez-Madrid, F., Nagy, J. A., Robbins, E., Simon, P., and Springer, T. A., 1983, A human leukocyte differentiation antigen family with distinct a-subunits and a common ß-subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM 1 /Mac-1), and the p150,95 molecule, J. Exp. Med. 158: 1785–1803.
Schifferli, J. A., Ng, Y. C., Estreicher, J., and Walport, M. J., 1988, The clearance of tetanus toxoid/antitetanus toxoid immune complexes from the circulation of humans. Complement-and erythrocyte complement receptor 1–dependent mechanisms, J. Immunol. 140: 899–904.
Schlesinger, L. R., and Horwitz, M. A., 1991, Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR (CDI lc/CD18) and IFN-7 activation inhibits complement receptor function and phagocytosis of this bacterium, J. Immunol. 147: 1983–1994.
Schweinle, J. E., Ezekowitz, R. A., Tenner, A. J., Kuhlman, M., and Joiner, K. A., 1989, Human mannosebinding protein activates the alternative complement pathway and enhances serum bactericidal activity on a mannose-rich isolate of Salmonella, J. Clin. Invest. 84: 1821–1829.
Sellar, G. C., Blake, D. J., and Reid, K. B. M., 1991, Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C l q. The complete derived amino acid sequence of human Clq, Biochem. J. 274: 481–490.
Seya, T., Turner, J., and Atkinson, J. P., 1986, Purification and characterization of membrane cofactor protein (MCP or gp 45–70) which is a cofactor for cleavage of C3b and C4b, J. Exp. Med. 163: 837–855.
Shiraishi, S, and Stroud, R. M., 1975, Cleavage products of C4b produced by enzymes in human serum, Immunochemistry 12: 935–939.
Shirato, M., Takahashi, K., Nagasawa, S., and Koyama, J, 1988, Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin, FEBS Lett. 234: 231–234.
Siciliano, S. J., Rollins, T. E., and Springer, M. S., 1990, Interaction between the C5a receptor and G; in both the membrane-bound and detergent-solubilized states, J. Biol. Chem. 265: 19568–19574.
Sim, E., Wood, A. B., Hsiung, L. M., and Sim, R. B., 1981, Pattern of degradation of human complement fragment C3b, FEBS Lett. 132: 55–60.
Sim, R. B., Arlaud, G. J., and Colomb, M. G., 1979, Cl inhibitor-dependent dissociation of human complement component CI bound to immune complexes, Biochem. J. 179: 449–457.
Simmons, D., Makgoba, M. W., and Seed, B., 1988, ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM, Nature (London) 331: 624–627.
Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C., and Anderson, D. C., 1989, Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro, J. Clin. Invest. 83: 2008–2017.
Solomon, E., Palmer, R. W., Hing, S., and Law, S. K. A., 1988, Regional localization of CD18, the ß-subunit of the cell surface adhesion molecule LFA-1, on human chromosome 21 by in situ hybridization, Ann. Hum. Genet. 52: 123–128.
Springer, T., Galfré, G., Secher, D. S., and Milstein, C., 1979, Mac-1: A macrophage differentiation antigen identified by monoclonal antibody, Eur. J. Immunol. 9: 301–306.
Stacker, S. A., and Springer, T. A., 1991, Leukocyte integrin p150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium, J. Immunol. 146: 648–655.
Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., and Springer, T. A., 1988, Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families, Cell 52: 925–933.
Staunton, D. E., Dustin, M. L., Erickson, H. P., and Springer, T. A., 1990, The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA- I and rhinovirus, Cell 61:243–254 [published erratum appears in Ce1161:1157].
Symon, F. A., Anandavijayan, S., and Fothergill, J. E., 1991, A receptor for C3a on HL60 cells, Complement, and Inflammation 8: 228.
Szebenyi, D. M. E., Obendorf, S. K., and Moffat, K., 1981, Structure of vitamin D dependent calcium-binding protein from bovine intestine, Nature (London) 294: 327–332.
Tack, B. F., Harrison, R. A., Janatova, J., Thomas, M. L., and Prahl, J. W., 1980, Evidence for presence of an internal thioester bond in the third component of complement, Proc. Natl. Acad. Sci. USA 77: 5764–5768.
Takada, Y., and Hemler, M. E., 1989, The primary structure of the VLA-2/collagen receptor a2 subunit (platelet GPIa): Homology to other integrins and the presence of a possible collagen-binding domain, J. Cell Biol. 109: 397–407.
Talamas-Rohana, P., Wright, S. D., Lennartz, M. R., and Russell, D. G., 1990, Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins, J. Immunol. 144: 4817–4824.
Taniguchi-Sidle, A., and Isenman, D. E., 1992, Mutagenesis of the Arg-Gly-Asp (RGD) triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18), J. Biol. Chem. 267: 635–643.
Tenner, A. J., 1989, Clq interactions with cell surface receptors, Behring Inst. Mitt. 84:220–235. Tenner, A. J., and Cooper, N. R., 1980, Analysis of receptor-mediated Clq binding to human peripheral blood mononuclear cells, J. Immunol. 125: 1658–1664.
Tenner, A. J., and Cooper, N. R., 1982, Stimulation of a human polymorphonuclear leukocyte oxidative response by the C lq subunit of the first complement component, J. Immunol. 128: 2547–2552.
Tenner, A. J., Robinson, S. L., Borchelt, J., and Wright, J. R., 1989, Human pulmonary surfactant protein (SP-A), a protein structurally homologous to Clq, can enhance FcR- and CR1–mediated phagocytosis, J. Biol. Chem. 264: 13923–13928.
Thiel, S., and Reid, K. B. M., 1989, Structures and functions associated with the group of mammalian lectins containing collagen-like sequences, FEBS Lett. 250: 78–84.
Todd, R. F., IIl, Arnaout, M. A., Rosin, R. E., Crowley, C. A., Peters, W. A., and Babior, B. M., 1984, Subcellular localization of the large subunit of Mo 1 (Mo 1 a; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion, J. Clin. Invest. 74: 1280–1290.
Tosi, M., Duponchel, C., Meo, T., and Julier, C., 1987, Complete cDNA sequence of human complement C l s and close physical linkage of the homologous genes C I s and C 1 r, Biochemistry 26: 8516–8524.
van Dyne, S., Holers, V. M., Lublin, D. M., and Atkinson, J. P., 1987, The polymorphism of the C3b/C4b receptor in the normal population and in patients with systemic lupus erythematosus, Clin. Exp. Immunol. 68: 570–579.
Voss, T., Eistetter, H., Schafer, K. P., and Engel, J., 1988, Macromolecular organization of natural and recombinant lung surfactant protein SP 28–36. Structural homology with the complement factor C 1 q, J. Mol. Biol. 201: 219–227.
Voss, T., Melchers, K., Scheirle, G., and Schäfer, K. P., 1991, Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: Implications for the chain composition of natural human SP-A, Am. J Respir. Cell Mol. Biol. 4: 88–94.
Waxman, F. J., Herbert, L. A., Cornacoff, J. B., Vanaman, M. E., Smead, W. F., Kraut, E., Birmingham, D. J., and Taguiam, J. M., 1984, Complement depletion accelerates the clearance of immune complexes from the circulation of primates, J. Clin. Invest. 74: 1329–1340.
Weiler, J. M., Daha, M. R., Austen, K. F., and Fearon, D. T., 1976, Control of the amplification convertase of complement by the plasma protein ß1H, Proc. Natl. Acad. Sci. USA 73: 3268–3272.
Weis, J. H., Morton, C. C., Bruns, G. A. P., Weis, J. J., Klickstein, L. B., Wong, W. W., and Fearon, D. T., 1987, A complement receptor locus: Genes encoding C3b/C4b receptor and C3d/Epstein—Barr virus receptor map to 1q32, J. Immunol. 138: 312–315.
Weis, J. J., Tedder, T. F., and Fearon, D. T., 1984, Identification of a 145,000 M membrane protein as the C3d receptor (CR2) of human B lymphocytes, Proc. Natl. Acad. Sci. USA 81: 881–885.
Weis, J. J., Toothaker, L. E., Smith, J. A., Weis, J. H., and Fearon, D. T., 1988, Structure of the human B lymphocyte receptor for C3d and the Epstein—Barr virus and relatedness to other members of the family of C3/C4 binding proteins, J. Exp. Med. 167: 1047–1066 [published erratum appears in J. Exp. Med. 168:1953–1954].
Weisman, H. F., Bartow, T., Leppo, M. K., Marsh, H. C. J., Carson, G. R., Concino, M. F., Boyle, M. P., Roux, K. H., Weisfeldt, M. L., and Fearon, D. T., 1990, Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis, Science 249: 146–151.
Weitkamp, L. R., and Lamm, L. U., 1982, Report of the committee on the genetic constitution of chromosome 6, Cytogenet. Cell Genet. 32: 130–143.
Weitzman, J. B., and Law, S. K. A., 1992, CR3 and its relationship with other phagocytic receptors, in Complement in Health and Disease, 2nd edition ( K. Whaley, ed.), pp. 265–293, Kluwar Academic Publishers, Lancaster.
Weitzman, J. B., Wells, C. E., Wright, A. H., Clark, P. A., and Law, S. K. A., 1991, The gene organisation of the human ß2 integrin subunit (CD18), FEBS Leu. 294: 97–103.
Whaley, K., and Ruddy, S., 1976, Modulation of C3b haemolytic activity by a plasma protein distinct from C3b-inactivator, Science 193: 1011–1013.
Whitehead, A. S., Solomon, E., Chambers, S., Bodmer, W. F., Povey, S., and Fey, G., 1982, Assignment of the structural gene for the third component of human complement to chromosome 19, Proc. Natl. Acad. Sci. USA 79: 5021–5025.
Wilson, J. G., Murphy, E. E., Wong, W. W., Klickstein, L. B., Weis, J. H., and Fearon, D. T., 1986, Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erthyrocytes, J. Exp. Med. 164: 50–62.
Wilson, J. G., Wong, W. W., Murphy, E. E., Schur, P. H., and Fearon, D. T., 1987, Deficiency of the C3b/C4b receptor (CR1) of erythrocytes in systemic lupus erythematosus: Analysis of the stability of the defect and of a restriction fragment length polymorphism of the CRI gene, J. Immunol. 138: 2706–2710.
Wong, W. W., Wilson, J. G., and Fearon, D. T., 1983, Genetic regulation of a structural polymorphism of human C3b receptor, J. Clin. Invest. 72: 685–693.
Wright, S. D., and Jong, M. T., 1986, Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide, J. Exp. Med. 164: 1876–1888.
Wright, S. D., and Meyer, B. C., 1986, Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes, J. Immunol. 136: 1759–1764.
Wright, S. D., and Silverstein, S. C., 1982, Tumor-promoting phorbol esters stimulated C3b and C3b’ receptor-mediated phagocytosis in cultured human monocytes, J. Exp. Med. 156: 1149–1164.
Wright, S. D., and Silverstein, S. C., 1983, Receptors for C3b and Cb3i promote phagocytosis but not the release of toxic oxygen from human phagocytes, J. Exp. Med. 158: 2016–2023.
Wright, S. D., Craigmyle, L. S., and Silverstein, S. C., 1983a, Fibronectin and serum amyloid P component stimulate C3b-and C3bi-mediated phagocytosis in cultured human monocytes, J. Exp. Med. 158: 1338–1343.
Wright, S. D., Rao, P. E., Van Voorhis, W. C., Craigmyle, L. S., Iida, K., Talle, M. A., Westberg, E. F., Goldstein, G., and Silverstein, S., 1983b, Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies, Proc. Natl. Acad. Sci. USA 80: 5699–5703.
Wright, S. D., Licht, M. R., Craigmyle, L. S., and Silverstein, S. C., 1984, Communication between receptors for different ligands on a single cell: Ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes, J. Cell Biol. 99: 336–339.
Wright, S. D., Detmers, P. A., Jong, M. T. C., and Meyer, B. C., 1986, Interferon-7 depresses binding of ligand by C3b and C3bi receptors on cultured human monocytes, an effect reversed by fibronectin, J. Exp. Med. 163: 1245–1259.
Wright, S. D., Reddy, P. A., Jong, M. T., and Erickson, B. W., 1987, C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp, Proc. Natl. Acad. Sci. USA 84: 1965–1968.
Wright, S. D., Weitz, J. I., Huang, A. J., Levin, S. M., Silverstein, S. C., and Loike, J. D., 1988, Complement receptor type three (CD 11 b/CD 18) of human polymorphonuclear leukocytes recognizes fibrinogen, Proc. Natl. Acad. Sci. USA 85: 7734–7738.
Wright, S. D., Levin, S. M., Jong, M. T. C., Chad, Z., and Kabbash, L. G., 1989, CR3 (Cdl lb/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide, J. Exp. Med. 169: 175–183.
Yamaguchi, N., Benya, P. D., van der Rest, M., and Nimomiya, Y., 1989, The cloning and sequencing of a1 (VIII) collagen cDNAs demonstrate that the type VIII collagen is a short chain collagen and contains triple helical and carboxyl-terminal non-triple-helical domains similar to those of type X collagen, J. Biol. Chem. 264: 16022–16029.
Yamamoto, K., and Johnston, R. B., Jr., 1984, Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages, J. Exp. Med. 159: 405–416.
Ziccardi, R. J., and Cooper, N. R., 1979, Active disassembly of the first complement component, Cl, by Cl inactivator, J. Immunol. 123: 788–792.
Zohair, A., Chesne, S., Wade, R. H., and Colomb, M. G., 1989, Interaction between complement subcomponent Clq and bacterial lipopolysaccharides, Biochem. J. 257: 865–873.
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Law, S.K.A. (1993). Complement Receptors. In: Horton, M.A. (eds) Macrophages and Related Cells. Blood Cell Biochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9534-9_9
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