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Function and Structure of the Red Blood Cell Cytoskeleton

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Book cover Erythroid Cells

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 1))

Abstract

Mature red blood cells of mammals consist only of cytoplasm and a cell membrane: they lack nucleus, mitochondria, and all other organelles. Cytoplasm contains all enzymes of glycolysis and the hexose monophosphate shunt, and some of those for nucleoside and nucleotide metabolism. These systems provide energy-rich phosphate as ATP and reducing power as NADH and NADPH, as in any other cell. Since most of the synthetic systems for biochemical compounds are lacking in red cells, ATP is mostly consumed on the cell membrane, except for priming to pump glycolysis. The erythrocyte membrane usually obtained by osmotic hemolysis is composed of a lipid bilayer and a fibrous undercoat structure; the latter is generally classified as a part of the cytoskeleton.

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Abbreviations

ACD blood:

blood preserved with acid—citrate—dextrose (NIH formula A)

PCD blood:

blood preserved with phosphate—citrate—dextrose

Hb:

hemoglobin

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

PS:

phosphatidylserine

PI:

phosphatidylinositol

WGA:

wheat germ agglutinin.

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  1. Department of Biochemistry, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan

    Makoto Nakao

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  1. North East Thames Regional Transfusion Centre, CM15 8DP, Brentwood, Essex, England

    J. Robin Harris

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Nakao, M. (1990). Function and Structure of the Red Blood Cell Cytoskeleton. In: Harris, J.R. (eds) Erythroid Cells. Blood Cell Biochemistry, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9528-8_7

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  • DOI: https://doi.org/10.1007/978-1-4757-9528-8_7

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