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The Transferrin Receptor and Iron Accumulation in Erythroid Cells

  • Chapter
Erythroid Cells

Part of the book series: Blood Cell Biochemistry ((BLBI,volume 1))

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Abstract

Developing erythroid cells need large amounts of iron mainly for heme formation but also for other essential biochemical reactions. Several obstacles have to be overcome in order to get the iron distributed to the right place in sufficient quantity at the right time. In the ionic state, iron is reactive, potentially toxic, and poorly soluble. This imposes the need for appropriate carrier functions both outside and inside cells and during passage through hydrophobic membranes. The interval during erythroid differentiation with intense heme synthesis is limited, and creates a demand for an efficient iron extraction mechanism that can be turned on or shut off according to the actual iron requirement.

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  1. Research and Development, Kabi, S-112 87, Stockholm, Sweden

    Klas Forsbeck

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  1. North East Thames Regional Transfusion Centre, CM15 8DP, Brentwood, Essex, England

    J. Robin Harris

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Forsbeck, K. (1990). The Transferrin Receptor and Iron Accumulation in Erythroid Cells. In: Harris, J.R. (eds) Erythroid Cells. Blood Cell Biochemistry, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9528-8_13

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