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Biotechnology and Bioactive Polymers pp 249–258Cite as

Biodegradable Polymers for the Controlled Delivery of Vaccines

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Abstract

New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to administer vaccines using biodegradable polymer carriers. Delivery systems composed of synthetic poly[esters] and poly[iminocarbonates] and natural (crosslinked serum albumin) biodegradable polymers are described. The antibody levels in response to these systems are presented, and possible mechanisms responsible for the observed effects are discussed. The important questions that need to be answered before this technology can be successfully applied are also discussed.

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Author information

Authors and Affiliations

  1. Division of Pharmaceutics, University of Iowa, Iowa City, Iowa, 52242, USA

    E. Schmitt, D. R. Flanagan & R. J. Linhardt

  2. Division of Medicinal and Natural Products Chemistry College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242, USA

    E. Schmitt, D. R. Flanagan & R. J. Linhardt

Authors
  1. E. Schmitt
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  2. D. R. Flanagan
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  3. R. J. Linhardt
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Editor information

Editors and Affiliations

  1. Lionfire, Inc., Edgewater, Florida, USA

    Charles G. Gebelein

  2. Florida Atlantic University, Boca Raton, Florida, USA

    Charles G. Gebelein  & Charles E. Carraher Jr.  & 

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© 1994 Springer Science+Business Media New York

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Schmitt, E., Flanagan, D.R., Linhardt, R.J. (1994). Biodegradable Polymers for the Controlled Delivery of Vaccines. In: Gebelein, C.G., Carraher, C.E. (eds) Biotechnology and Bioactive Polymers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9519-6_24

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  • DOI: https://doi.org/10.1007/978-1-4757-9519-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9521-9

  • Online ISBN: 978-1-4757-9519-6

  • eBook Packages: Springer Book Archive

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