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Blood-Brain Barrier Permeability Changes during Semliki Forest Virus-Induced Encephalomyelitis in the Balb/c Mouse

A Role for Histamine?

  • Chapter
Biology and Physiology of the Blood-Brain Barrier

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 46))

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Summary

We have measured blood-brain barrier permeability changes during Semliki Forest Virus infections in the Balb/c mouse, and shown that the permeability changes have a biphasic response peaking at post inoculation days 5 and 14. The histamine H2 receptor antagonist, cimetidine reduced the permeability changes at post inoculation day 5.

Résumé

Nous avons mesuré les modifications de la perméabilité de la barrière hématoencéphalique au cours de l’infection de souris Balb/c par le virus semliki Forest. Nous avons montré que la perméabilité de la BHE est modifiée en deux phases avec des maximums 5 et 14 jours après l’inoculation du virus. L’admistration de cimétidine, antagoniste du récepteur histaminergique H2, réduit l’augmentation de la perméabilité apparaissant 5 jours après l’inoculation du virus.

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Author information

Authors and Affiliations

  1. Physiology Department, U.M.D.S, St Thomas’ Hospital, London, SE1 7EH, UK

    R. D. Egleton, A. M. Butt & M. B. Segal

  2. Immunology Department U.M.D.S, St Thomas’ Hospital, London, SE1 7EH, UK

    S. Amor

Authors
  1. R. D. Egleton
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  2. A. M. Butt
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  3. S. Amor
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  4. M. B. Segal
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Editor information

Editors and Affiliations

  1. Institut Cochin de Génétique Moléculaire, Paris, France

    Pierre-Olivier Couraud

  2. CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France

    Daniel Scherman

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© 1996 Springer Science+Business Media New York

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Egleton, R.D., Butt, A.M., Amor, S., Segal, M.B. (1996). Blood-Brain Barrier Permeability Changes during Semliki Forest Virus-Induced Encephalomyelitis in the Balb/c Mouse. In: Couraud, PO., Scherman, D. (eds) Biology and Physiology of the Blood-Brain Barrier. Advances in Behavioral Biology, vol 46. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9489-2_59

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  • DOI: https://doi.org/10.1007/978-1-4757-9489-2_59

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9491-5

  • Online ISBN: 978-1-4757-9489-2

  • eBook Packages: Springer Book Archive

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