Abstract
Substance P (SP), a neuropeptide released by peripheral sensory neurons, plays an important role in pain perception and acute inflammation (Sandberg and Iverson, 1982). It is also involved in peripheral autoimmune inflammatory diseases, most clearly with experimental adjuvant arthritis. Rats with adjuvant arthritis develop increased levels of SP in nerves innervating the arthritic joints, and depleting these animals of SP with capsaicin ameliorates the arthritis (Colpaert et al., 1983). Conversely, adding exogenous SP to the joint makes the arthritis more severe (Levine et al., 1984). Acute injury stimulates the release of SP (up to 2.8×10−15M into lymph) within 5–10 minutes (Jonsson et al., 1986). SP levels in blister fluid from infections, eczema, and bullous pemphigoid can be 3×10−11M (Wallengren et al., 1986), while SP in acute inflammatory exudates can be as much as 2×10−9M (Tissot et al., 1988), indicating high levels of SP secretion under these conditions. Inflammatory bowel disease tissue has a 1000-fold increase in SP receptors and is another instance where SP may be contributing to chronic inflammation (Mantyh et al., 1988).
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References
Adams, C.W.M., Abdulla, Y.H., Tomes, E.M., and Poston, R.N., 1987, Periventricular lesions in multiple sclerosis: their perivenous origin and relationship to granular ependymitis, Neuropath. Appl. Neurobiol. 13: 141.
Aggarwal, B.B., Kohr, W.J., Hass, P.E., Moffat, B., Spencer, S.A., Henzel, W.J., Bringman, T.S., Nedwin, G.E., Goeddel, D.V. and Harkins, R.N., 1985, Human tumor necrosis factor: production, purification, and characterization, J. Biol. Chem. 260: 2345.
Bailey, S.J., Featherstone, R.L., Jordan, C.C. and Morton, I.K.M., 1986, An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes, Brit. J. Pharmacol. 87: 79.
Bar-Shavit, Z., Goldman. R., Stabinski, Y., Gottlieb, P., Fridkin, M., Teichberg, V.I., and Blumberg, S., 1980, Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence, J. Immunol. 130: 89.
Beaujouan, J.C., Torrens, Y., Saffroy, M., and Glowinski, J., 1986, Quantitative autoradiographic analysis of the distribution of binding sites for 125E Bolton Hunter derivatives of eledoisin and substance P in the rat brain, Neurosci. 18: 857.
Brandwein, S.R., 1986, Regulation of interleukin-1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferon, J. Biol. Chem. 261: 8624.
Broman, T., 1964, Blood-brain barrier damage in multiple sclerosis supravital test observations, Acta Neurol. Scand. 40 (Suppl. 10): 21.
Buck, S.H., Maurin, Y., Burks, T.F., and Yamamura, H.I., 1984, High-affinity 3H-substance P binding to longitudinal muscle membranes of the guinea pig small intestine, Life Sci. 34: 497.
Burcher, E., and Buck, S.H., 1986, Multiple tachykinin binding sites in hamster, rat, and guinea pig urinary bladder, Eur. J. Pharmacol. 128: 165.
Bynke, G., Hakanson, R., Horig, J., and Leander, S., 1983, Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance P, Eur. J. Pharmacol. 91: 469.
Carpenter, M.B., 1969, “Human Neuroanatomy,” The Williams and Wilkins Company, Baltimore.
Cavender, D., Haskard, D., Yu, C-L., Iguchi, T., Miossec, P., Oppenheimer-Marks, N., and Ziff, M., 1987, Pathways to chronic inflammation in rheumatoid synovitis, FASEB J. 46: 113.
Charles, A.C., Merrill, J.E., Dirksen, E.R., and Sanderson, M.J., 1991, Intercellular signaling in glial cells: calcium waves and oscillations in response to mechanical stimulation and gluatamate, Neuron 6: 983.
Charles, A.C., Dirksen, E.R., Merrill, J.E., and Sanderson, M.J., Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin, Glia, in press.
Colpaert, F.C., Donnerer,.J, and Lembeck, F., 1983, Effects of capsaicin on inflammation and on the substance P content of nervous tissue in rats with adjuvant arthritis, Life Sci. 32: 1827.
Conlon, P.J., 1983, A rapid biologic assay for the detection of interleukin 1, J. Immunology 131: 1280.
Conrad, G.W., and Rink, T.J., 1986, Platelet activating factor raises intracellular calcium ion concentration in macrophages, J. Cell Biol. 103: 439.
Dinarello, C.A. and Savage, N., 1989, Interleukin-1 and its receptor, Crit. Rev. Immunol. 9: 1.
Edvinsson, L., McCulloch, J. and Uddman, R., 1982, Feline cerebral veins and arteries: comparison of autonomic innervation and vasomotor responses, J. Physiol. 325: 161.
Edvinsson, L., Cervos-Navarro, J., Larsson, L-I., Owman, C.H., and Ronnberg A-L., 1977, Regional distribution of mast cells containing histamine, dopamine, or 5-hydroxytryptamine in the mammalian brain, Neurol. 27: 878.
Fog, T., 1965, The topography of plaques in multiple sclerosis, Acta Neurol. Scand. 41 (Suppl. 15): 3.
Frank, E., Pulver, M., and de Tribolet, N., 1986, Expression of class II major histocompatibility antigens on reactive astrocytes and endothelial cells within the gliosis surrounding metastases and abscesses, J. Neuroimmunol. 12: 29.
Freemont AJ, and Ford WL: Functional and morphological changes in post capillary ventiles in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin, J. Pathol. 147: 1.
Graeber, M.B., Streit, W.J., Kiefer, R., Schoen, S.W., and Kreutzeberg, G.W., 1990, New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury. J. Neuroimmunol. 27: 121.
Hartung, H.-P., Heininger, K., Schafer, B., and Toyka, K.V., 1988, Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism, FASEB J. 2: 48.
Hartung, H.-P., Wolters, K. and Toyka, K.V., 1986, Substance P: Binding properties and studies on cellular responses in guinea pig macrophages, J. Immunl. 136: 3856.
Hashimoto, M., Ishikawa, Y., Yokota, S., Goto, F., Bando, T., Sakakibara, Y., and Iriki, M., 1991, Action site of circulating Interleukin-1 on the rabbit brain. Brain Res. 540: 217.
Hofman, F.M., von Hanwehr, R.I., Dinarello, C.A., Mizel, S.B., Hinton, D., and Merrill, J.E., 1986, Immunoregulatory molecules and IL2 receptors identified in multiple sclerosis brain, J. Immunol. 136: 3239.
Itakura, T., Okuno, T., Nakakita, K., Kamei, I., Naka, Y., Nakai, K., Imai, H., Komai, N., Kimura, H., and Maeda, T., 1984, A light and electron microsopic immunohistochemical study of vasoactive intestinal polypeptide-and substance P-containing nerve fibers along the cerebral blood vessels: comparison with aminergic and cholinergic fibers, J. Cereb. Blood Flow Metabol. 4: 407.
Jonsson, C-E., Brodin, E., Dalsgaard, C-J., and Haegerstrand, A. 1986, Release of substance-P-like immunoreactivity in dog paw lymph after scalding injury, Acta Physiol. Scand., 126: 21.
Kimball, E.S., Persico, F.J. and Vaught, J.L., 1988, Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 Cells, J. Immunol. 141: 3564.
Kostyk, S.K., Kowall, N.W., and Hauser, S.L., 1989, Substance P immunoreactive astrocytes are present in multiple sclerosis plaques, Brain Res. 504: 284.
Larsen, P.J., Mikkelsen, J.D., and Saermak, T., 1989, Binding of an iodinated substance P analog to an NK1 receptor on isolated cell membranes from rat anterior pituitary. Endocrinol. 124: 2548
Laurenzi, M.A., Persson, M.A.A., Dalsgaard, C.-J. and Haegerstrand, A., 1990, The neuropeptide substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide, Scand. J. Immunol. 31: 529.
Lechleiter, J., Hellmiss, R., Duerson, K., Ennulat, D., David, N., Clapham, D., and Peralta, E., 1990, Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes, EMBO J. 9: 4381.
Lemaire, I., 1988, Neurotensin enhances ILA production by activated alveolar macrophages, J. Immunol. 140: 2983.
Levine, J.D., Clark, R., Devor, M., Helms, C., Moskowitz, M.A., and Basbaum, A., 1984, Intraneuronal substance P contributes to the severity of experimental arthritis, Science 226: 547.
Lieberman, A.P., Pitha, P.M., Shin, H.S., and Shin, M.L. 1989, Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus, Proc. Natl. Acad. Sci. USA 86: 6348.
Lotz, M., Carson, D. and Vaughan, J.H., 1987, Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis, Science 238: 893.
Lotz, M., Vaughan, J.H., and Carson, D.A., 1988, Effect of neuropeptides on production of inflammatory cytokines by human monocytes, Science 241: 1218.
Lundberg, J.M., Martling, C-R., Saria, A., Folkers, K., and Rosell, S, 1983, Cigarette smoke-induced airway edema due to activation of capsaicin-sensitive vagal afferents and substance P release, Neurosci. 10: 1361.
Mantyh, C.R., Gates, T.S., Zimmerman, R.P., Welton, M.L., Passaro, E.P., Vigna, S.R., Maggio, J.E., Kruger, L., and Mantyh, P.W., 1988, Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodes in surgical specimens obtained from patients with ulcerative colitis and Crohn disease, Proc. Natl. Acad. Sci. 85: 3235.
Mantyh, P.W., Hunt, S.P., and Maggio, J.E., 1984, Substance P receptors: Localization by light microscopic autoradiography in rat brain using [3H]SP as the radio-ligand, Brain Res. 307: 147.
Mantyh, P.W., Johnson, D.J., Boehmer, C.G., Calton, M.D., Vinters, H.V., Maggio, J.E., Too, H.-P. and Vigna, S.R., 1989, Substance P receptor binding sites are expressed by glia in vivo after neuronal injury, Proc. Natl. Acad. Sci. USA 86: 5193.
Marshall, K.W., Chiu, B. and Inman, R.D., 1990, Substance P and arthritis: Analysis of plasma and synovial fluid levels, Arth. Rheum. 33: 87.
Martin, F.C., Anton, P.A., Gombein, J.A., Shanahan, F., and Merrill, J.E., Production of IL1 by microglia in response to substance P: role for a nonclassical NK1 receptor, J. Neuroimmunol.,in press, a.
Martin, F.C., Charles, A.C., Sanderson, M.J., and Merrill, M.J., Substance P stimulates IL1 production by astrocytes via intracellular calcium, Brain Res. in press, b.
Matthijs, B., Himpens, B., Peeters, T.L., and Vantrappen, G., 1990, Effects of substance P on [Ca2+]t and force in intact guinea pig ileal smooth muscle, Am. J. Physiol. 159: C150.
Merrill, J.E., 1991, Effects of interleukin-1 and tumor necrosis factor-a on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro, Devel. Neurosci. 13: 130.
McLean, S., Ganong, A.H., Seeger,. J.F., Bryce, D.K., Pratt, K.G., Reynolds, L.S., Siok, C.J., Lowe, J.A. III, and Heym, J., 1991, Activity and distribution of binding sites in brain of a non peptide substance P (NK) receptor antagonist, Science 251: 437.
Moore, R.N., Osmand, A.P., Dunn, J.A., Joshi, J.G. and Rouse, B.T., 1988, Substance P augmentation of CSF-1-stimulated in vitro myelopoiesis, J. Immunology 141: 2699.
Payan, D.G., Brewster, D.R., Missirian-Bastian, A. and Goetzel, E.J., 1984, Substance P recognition by a subset of human T lymphocytes, J. Clin. Invest. 74: 1532.
Pearce, B., Murphy, S., Eds., 1983, “Neurotransmitter Receptors Coupled to Inositol Phospholipid Turnover and Ca2+ Flux: Consequences for Astrocyte Function,” Raven Press, Ltd., New York.
Peck, R., 1987, Neuropeptides modulating macrophage function, Science 239: 264.
Prpic, V., Weiel, J.E., Somers, S.D., DiGuiseppi, J., Gonias, S.L., Pizzo, S.V., Hamilton, T.A., Herman, B., and Adams, D.O., 1987, Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages, J. Immunol. 139: 526.
Regoli, D., Drapeau, G., Dion, S. and D’Orleans-Juste, P., 1989, Receptors for substance P and related neurokinins, Pharmacology 38: 1.
Ruff, M.R., Wahl, S.M., and Pert, C.B., 1985, Substance P receptor-mediated chemotaxis of human monocytes, Peptides 6 (Suppl 2): 107.
Saito, K., Liu-Chen, L-Y., and Moskowitz, M.A., 1987, Substance P-like immunoreactivity in rat forebrain leptomeninges and cerebral vessels originates from the trigeminal but not sympathetic ganglia, Brain Res. 403: 55.
Sandberg, B.E.B., and Iversen, L.L., 1982, Substance P, J. Med. Chem. 25: 1009.
Saria, A., 1984, Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury, Brit. J. Pharmacol. 82: 217.
Schade, U.F., Burmeister, I., Elekes, E., Engel, R. and Wolter, D.T., 1989, Mononuclear phagocytes and eicosanoids: aspects of their synthesis and biological activities, Blut 59: 475.
Shanahan, F., Denburg, J.A., Fox, J., Bienenstock, J., and Befus, D., 1985, Mast cell heterogeneity: effects of neuroenteric peptides on histamine release, J. Immunol. 135: 1331.
Shinomiya, H., and Nakano, M., 1987, Calcium ionophore A23187 does not stimulate lipopolysaccharide nonresponsive C3H/HeJ peritoneal macrophages to produce interleukin 1, J. Immunology 139: 2730.
Snider, R.M., Constantine, J.W., III, J.A.L., Longo, K.P., Lebel, W.S., Woody, H.A., Drozda, S.E., Desai, M.C., Vinick, F.J., Spencer, R.W. and Hess, H.-J., 1991, A potent nonpeptide antagonist of the substance P (NK1) receptor, Science 251: 435.
Stanisz, A.M., Bufus, D., and Bienenstock, J., 1986, Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer’s patches, mesenteric lymph nodes, and spleen, J. Immunol. 136: 152.
Terada, Y., Shinomiya, H., and Nakano, M., 1989, Defect of calmodium-binding protein in expression of interleukin-113 gene by LPS-nonresponder C3H/HeJ mouse macrophages, Biochem. Biophys. Res. Com. 158: 723.
Thomas, K.L., Andrews, P.V., Khalil, Z., and Helme, R.D. 1989, Substance P induced hydrolysis of inositol phopolipids in rat skin in an in vivo model of inflammation, Neuropeptides 13: 191.
Thureson-Klein, A., Hedqvist, P., Ohlen, A., Raud, J., and Lindbom, L., 1987, Leukotriene B4, platelet-activating factor and substance P as mediators of acute inflammation, Pathol. Immunopathol. Res. 6: 190.
Tissot, M., Pradelles, P., and Giroud, J.P., 1988, Substance-P-like levels in inflammatory exudates. Inflammation 12: 25.
Torrens, Y., Beaujouan, J.C., and Glowinski, J., 1985, Pharmacological characterization of two tachykinin binding sites in the rat cerebral cortex, Neuropeptides 6: 59.
Torrens, Y., Beaujouan, J.C., Saffray, M., Daguet de MonTety, M.C., Bergstrom, L., and Glowinski, J., 1986, Substance P receptors in primary cultures of cortical astrocytes from the mouse, Proc. Natl. Acad. Sci. USA 83: 9216.
Torrens, Y., Daguet De Montety, M.C., El Etr, M., Beaujouan, J.C., and Glowinski, J., 1989, Tachykinin receptors of the NK1 type (substance P) coupled positively to phospholipase Con cortical astrocytes from the newborn mouse in primary culture, J. Neurochem. 52: 1913.
Wallengren, J., Ekman, R. and Moller, H., 1986, Substance P and vasoactive intestinal peptide in bullous and inflammatory skin disease, Acta Derm. Venereol. 66: 23.
Wienrich, M., and Kettenmanm, H., 1989, Activation of substance P receptors leads to membrane potential responses in cultured astrocytes, Glia 2: 155.
Woodroofe, M.N., Sama, G.W., Wadhwa, M., Hayes, G.M., Loughlin, A.J., Tinker, A., and Cuzner, M.L., 1991, Detection of interleukin 1 and interleukin 6 in adult rat brain following mechanical injury by in vivo microdialysis: evidence of a role for microglia in cytokine production, J. Neuroimmunol. 33: 227.
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Merrill, J.E., Charles, A.C., Martin, F.C. (1993). The Role of Substance P in Cytokine Production by Glial Cells. In: Fedoroff, S., Juurlink, B.H.J., Doucette, R. (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Altschul Symposia Series, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9486-1_19
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