Abstract
The induction of specific P450 enzymes is difficult to study in man but non-human primates may provide a useful model for this purpose. At present little is known about the inducibility of P450 in the liver or extrahepatic tissues of primates. Previous investigations have shown that several P450s are inducible in the marmoset monkey (Callithrix jacchus) by compounds such as phenobarbital or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Schulz-Schalge & Webb, 1989; Schulz-Schalge et al., 1991a).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Edwards RJ, Murray BP, Murray S, Schulz T, Neubert D, Gant TW, Thorgeirsson SS, Boobis AR, Davies DS (1994) Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. Carcinogenesis 15: 829–836
Edwards RJ, Murray BP, Singleton AM, Murray S, Davies DS, Boobis AR (1993) Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man. Biochem. Pharmacol. 46: 213–220
Murray S, Boobis AR (1986) An assay for paracetamol, produced by the O-deethylation of phenacetin in vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biomed. Environm. Mass Spectr. 13: 91–93
Schulz-Schalge T, Koch E, Golor G, Wiesmüller T, Hagenmaier HP, Neubert D (1991a) Comparison of the induction of cytochrome P450 and ethoxyresorufin O-deethylase by a single subcutaneous administration of TCDD in liver microsomes of marmoset monkeys (Callithrix jacchus) and rats. Chemosphere 23: 1933–1939
Schulz-Schalge T, Koch E, Schwind KH, Hutzinger O, Neubert D (1992b) Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations. Chemosphere 23: 1925–1931
Schulz-Schalge T, Heger W, Webb J, Kastner M, Neubert D (1991c) Ontogeny of some monooxygenase activities in the marmoset monkey (Callithrix jacchus). J. Med. Primatol. 20: 325–333
Schulz-Schalge T, Webb J (1989) Metabolism of some phenoxazone ethers in liver microsomes of untreated and phenobarbital-treated marmoset monkeys (Callithrix jacchus). Naunyn Schmiedebergs Arch. Pharmacol. 339: R 9
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Schulz, T.G., Neubert, D., Davies, D.S., Edwards, R.J. (1996). Induction of Cytochromes P450 by Dioxins in Liver and Lung of Marmoset Monkeys (Callithrix jacchus). In: Snyder, R., et al. Biological Reactive Intermediates V. Advances in Experimental Medicine and Biology, vol 387. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9480-9_53
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9480-9_53
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9482-3
Online ISBN: 978-1-4757-9480-9
eBook Packages: Springer Book Archive